Wyniki wyszukiwania

1

A functional study of the dexamethasone-induced steroid receptor in Tetrahymena

100%

Kohidai L., Csaba G.

Acta Protozoologica

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1990

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tom 29

|

nr 1

2

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Prenatal glucocorticoids can programme postnatal development

100%

Tomaszewska E., Dobrowolski P.

Journal of Pre-Clinical and Clinical Research

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2011

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tom 05

|

nr 1

3

Transforming growth factor-beta1 upregulates myostatin expression in mouse C2C12 myoblasts

100%

Budasz-Swiderska M., Jank M., Motyl T.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 3

195-214

Myostatin (MSTN) and transforming growth factor-ß1 (TGF-ß1) belong to the same TGF-ß superfamily of proteins. They are involved in regulation of skeletal muscle growth and development as well as muscle catabolism. The aim of the present study was to investigate the relationship between mstn and TGF-ß1 expression in proliferating and differentiating mouse C2C12 myoblasts cultured in normal and catabolic conditions and to evaluate the effect of exogenous TGF-ß1 as well as "knock down" of TGF-ß1 receptor type II on mstn expression in proliferating and differentiating myogenic cells. The direct effect of TGF-ß1 on myostatin was also examined. Myostatin expression increased gradually with cell confluency in proliferating cultures, while the level of TGF-ß1, detected in the form of a 100 kDa small latent complex diminished. Myostatin expression was accompanied by a partial cell cycle arrest. Three forms of myostatin were found: a 52 kDa precursor, a 40 kDa latency associated propeptide, and a 26 kDa active peptide. A decrease in myostatin and TGF-ß1 levels was observed during the first three days of differentiation, which was subsequently followed by significant increase of their expression during next three to four days of differentiation. Catabolic state induced by dexamethasone significantly increased the level of all forms of myostatin as well as latent (100 kDa) and active (25 kDa) forms of TGF-ß1 in differentiating myoblasts in a dose dependent manner. Exogenous TGF-ß1 (2 ng/ml) significantly increased myostatin levels both in proliferating and differentiating C2C12 myoblasts, whereas silencing of the TGF-ß1 receptor II gene significantly lowered myostatin level in examined cells. The presented results indicate that TGF-ß1 may control myostatin-related regulation of myogenesis through up-regulation of myostatin, predominantly in the course of terminal differentiation and glucocorticoid-dependent catabolic stimulation.

4

Effect of maternal administration of dexamethasone during last weeks of pregnancy on foetal skeletal system in pigs

100%

Sliwa E., Kowalik S., Tatara M. R., Studzinski T.

Bulletin of the Veterinary Institute in Puławy

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2004

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tom 48

|

nr 4

5

Changes in glucocorticoid-induced apoptosis and in expression of Bcl-2 protein during long-term culture of thymic lymphoma

100%

Kobzdej M., Matuszyk J., Ziolo E., Strzadala L.

Archivum Immunologiae et Therapiae Experimentalis

|

2000

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tom 48

|

nr 1

6

Effects of dexamethasone on physical properties and mineral density of long bones in piglets

100%

Sliwa E., Kowalik S., Tatara M. R., Majcher P., Krupski W., Studzinski T.

Bulletin of the Veterinary Institute in Puławy

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2005

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tom 49

|

nr 1

7

The effect of dexamethasone on phosphatidylcholine species composition in fetal rat lungs

100%

Stettner S., Ledwozyw A.

Archivum Veterinarium Polonicum

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1995

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tom 35

|

nr 1-2

8

Effect of dexamethasone on the treatment of lung oedema induced by oleic acid in dogs

100%

Borku M. K., Ozkanlar Y., Saglam Y. S., Hayirli A., Hanedan B., Karakurum C., Aktas M. S., Kirmizigul A. H.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

|

nr 3

The therapeutic effect of 1 mg/kg of dexamethasone on lung oedema and respiratory distress induced by 0.08 mg/kg of oleic acid (OA) in dogs was investigated into 8 dogs. One hour after OA injection, blood pH, HCO₃, pO₂, O₂Hb, and heart rate decreased, whereas COHb, pCO₂, temperature, and respiration rate increased. Lung oedema was confirmed histopathologically in a dog from the control group who died. Blood pH, COHb, temperature, and respiration rate returned to normal values after administration of dexamethasone. It has been determined that respiratory distress and lung oedema cause important changes in blood gases and the administration of a single dose of 1 mg/kg of dexamethasone is effective in the treatment of lung oedema and respiratory distress induced in dogs by OA.

9

Reverse 3,3',5'-triiodothyronine influences the hyperglycaemia in chickens induced by dexamethasone and exogenous glucose; Lack of effect on hyperglycaemia elicited by adrenaline

100%

Bobek S., Sechman A., Niezgoda J., Jacek T.

Roczniki Naukowe Zootechniki. Suplement

|

2001

|

tom 12

10

Cholinergic innervation of cystic porcine ovaries

100%

Kozlowska A., Wojtkiewicz J., Majewski M., Jana B.

Medycyna Weterynaryjna

|

2008

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tom 64

|

nr 04B

The aim of the study was to examine the changes in the density of VAChT (marker of acetylcholine present)-, NPY-, VIP-, SOM-, SP- and nNOS-immunoreactive (IR) nerve terminals and co-localization of VAChT with the above-mentioned neurotransmitters after the occurrence of dexamethasone (DXM)-induced ovarian cysts in gilts. DXM administration led to an increase in the density of VAChT/SP-, VAChT/nNOS- and NPY-IR nerve terminals around the cystic walls. In DXM-treated animals an elevated number of VAChT- and SP-IR nerve endings was found close to the tertiary follicles. Moreover, in the gilts receiving DXM the density of NPY-IR nerve endings (that simultaneously co-localized VAChT) was high near the interstitial gland. An increase in the number of VAChT/SP- and VIP-IR nerve fibers around the medullar arteries (A) was observed in cystic ovaries, while the number of VAChT-IR nerve endings near the cortical A was lowered after DXM application. Furthermore, nerve fibers containing VAChT were absent around veins in the whole ovary of DXM-treated animals. After DXM injections, an increase in the number of VAChT/SP- and VAChT/nNOS-IR nerve endings in the cortical, as well as VIP- and nNOS-IR (co-existing with VAChT), nerve terminals in the medullar part of the autonomic ground plexus (GP) was present. However, the administration of DXM led to a drop in the density of SOM-positive nerve endings (also VAChT-IR) in the medullar subdivision of the GP. The present study shows that in the porcine ovaries with DXM induced cysts the pattern of cholinergic innervation, as well as the co-localization of VAChT and NPY, VIP, SOM, SP or nNOS, were changed. Data obtained also suggest that acetylcholine and the above-mentioned neurotransmitters effecting the functioning (steroidogenic activity, blood flow) of the polycystic ovaries may have a significant influence on the course of this pathological status.

11

The efficacy of combination therapy with lenalidomide and dexamethasone in the treatment of relapsed multiple myeloma

84%

Szudy-Szczyrek A., Legiec W., Manko J., Gmyz K., Szczyrek M., Hus M.

Health Problems of Civilization

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2015

|

tom 09

|

nr 2

Multiple myeloma is a neoplastic disease which is characterised by proliferation of monoclonal plasmocytes in the bone marrow. It is the second most common hematologic cancer and it represents 1% of all cancer deaths. Despite enormous development in multiple myeloma biology and treatment over the last 30 years - it is still incurable disease with a median survival of 50 – 55 months. Currently, one of the most important goals in the treatment of multiple myeloma is to achieve long-term control of the disease, without negative impact on the patient’s quality of life. Thanks to therapeutic regimens based on new immunomodulatory drugs, this aim seems to be achievable. In this paper we present the case of a female patient living with multiple myeloma for 14 years. Initially patient was treated with standard VAD (vincristine, doxorubicin, dexamethasone) chemotherapy regimen. After a nearly complete remission of the disease, autotransplantation of hematopoietic cells was performed. One year after transplantation there was a relapse of the disease. In the treatment of relapse it was decided to use scheme based on lenalidomide and dexamethasone. After 4th cycle of treatment, a complete remission was achieved. So far, the patient received 149 cycles. In the evaluation of minimal residual disease still maintains a state of complete remission maintains. During over 12 years of treatment no complications in grade 3 and 4 of the CTCAE v.4 was observed. Currently the patient is 58 years old, she still receives lenalidomide and leads moderately active life.

12

The effect of CRH, dexamethasone and naltrexone on the mu, delta and kappa opioid receptors agonist binding in lamb hypothalamic-pituitary-adrenal axis

84%

Pierzchala-Koziec K., Dziedzicka-Wasylewska M., Oeltgen P., Zubel-Lojek J., Latacz A., Oclon E.

Folia Biologica

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2015

|

tom 63

|

nr 3

13

Assessment of neurotoxicity of pharmacological compounds during early neural development of human embryonic stem cells

84%

Kang H. Y., Hong E. J., Kang H. S., Ahn C., Jeung E. B.

Journal of Physiology and Pharmacology

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2017

|

tom 68

|

nr 2

14

A mutein of human basic fibroblast growth factor TGP-580 accelerates colonic ulcer healing by stimulating angiogenesis in the ulcer bed in rats

84%

Satoh H., Szabo S.

Journal of Physiology and Pharmacology

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2015

|

tom 66

|

nr 5

15

Dexamethasone effects on Bax expression in the mouse testicular germ cells

84%

Mahmoud H., Mahmoud O., Layasadat K., Naeim A.

Folia Histochemica et Cytobiologica

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2009

|

tom 47

|

nr 2

237-241

16

Regulatory effect of dexamethasone on tracheal calcium processing proteins and mucosal secretion

84%

Lee B., Ahn C., Jeon B.-H., Jung E.-M., Yoo Y.-M., Jeung E.-B.

Journal of Physiology and Pharmacology

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2019

|

tom 70

|

nr 1

17

Current approaches for the treatment of autoimmune hemolytic anemia

84%

Jaime-Perez J. C., Rodriguez-Martinez M., Gomez-de-Leon A., Tarin-Arzaga L., Gomez-Almaguer D.

Archivum Immunologiae et Therapiae Experimentalis

|

2013

|

tom 61

|

nr 5

18

Effect of simultaneous versus apart administration of dexamethasone and alpha-ketoglutarate on growth hormone, cortisol and insulin-like growth factor-I in piglets

84%

Sliwa E.

Bulletin of the Veterinary Institute in Puławy

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2006

|

tom 50

|

nr 2

19

Role of nitric oxide in the vasopressin-induced corticosterone secretion in rats

84%

Bugajski J., Gadek-Michalska A., Olowska A., Borycz J., Glod R.

Journal of Physiology and Pharmacology

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1997

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tom 48

|

nr 4

20

Interference between DNA binding activities of AP-1 and GR transcription factors in rats thymocytes undergoing dexamethasone-induced apoptosis

84%

Sikora E., Rossini G. P., Grassilli E., Bellesia E., Salomoni P., Franceschi C.

Acta Biochimica Polonica

|

1996

|

tom 43

|

nr 4

The early molecular events of glucocorticoid-induced apoptosis have been investigated by studying glucocorticoid receptor levels, as well as binding activities to GRE and AP-1 sequences, using nuclear extracts from dexamethasone (Dex)-treated rat thymocytes. When the time-course of glucocorticoid-receptor complexes in nuclei of thymocytes was evaluated by binding studies using the tritiated ligand, we found that nuclear accumulation of radioactive complexes occurred in the first hour of incubation, and was followed by a progressive decline. This trend was confirmed by immunoblotting of nuclear proteins using a monoclonal anti-glucocorticoid receptor antibody. When the kinetics of binding activity to AP-1 and GRE sequences were studied, using nuclear extracts prepared from Dex-treated thymocytes in gel shift assays, we found peaks at 1 and 2 h after Dex treatment, and a return to basal levels in the following hours. Binding specificity was proved by competition studies using non-radioactive sequences, including mutated AP-1. Unexpectedly, however, protein binding to GRE was better competed for by AP-1 sequence than by GRE itself. Data obtained using the super gel shift assay suggested that AP-l/Jun can be responsible for the high affinity for the GRE sequence. Thus, we report here for the first time that an interference between AP-1 and GR in the binding to DNA consensus sequences — previously described in other biological systems — also occurs during apoptosis induced by glucocorticoids in lymphoid cells.

Ograniczanie wyników

A functional study of the dexamethasone-induced steroid receptor in Tetrahymena

Prenatal glucocorticoids can programme postnatal development

Transforming growth factor-beta1 upregulates myostatin expression in mouse C2C12 myoblasts

Effect of maternal administration of dexamethasone during last weeks of pregnancy on foetal skeletal system in pigs

Changes in glucocorticoid-induced apoptosis and in expression of Bcl-2 protein during long-term culture of thymic lymphoma

Effects of dexamethasone on physical properties and mineral density of long bones in piglets

The effect of dexamethasone on phosphatidylcholine species composition in fetal rat lungs

Effect of dexamethasone on the treatment of lung oedema induced by oleic acid in dogs

Reverse 3,3',5'-triiodothyronine influences the hyperglycaemia in chickens induced by dexamethasone and exogenous glucose; Lack of effect on hyperglycaemia elicited by adrenaline