Wyniki wyszukiwania

1

On the systemic approach to balance deficiency

100%

Kowalska-Napora E.

Zeszyty Naukowe Uniwersytetu Przyrodniczo-Humanistycznego w Siedlcach. Seria: Administracja i Zarządzanie

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2013

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nr 25[98]

2

The expression of inducible nitric oxide synthase [iNOS] in the testis and epididymis of rats with a dihydrotestosterone [DHT] deficiency

100%

Kolasa A., Marchlewicz M., Kurzawa R., Glabowski W., Trybek G., Wenda-Rozewicka L., Wiszniewska B.

Cellular and Molecular Biology Letters

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2009

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tom 14

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nr 3

511-527

In our previous studies, we showed that a finasteride-induced DHT deficiency may cause changes in the morphology of the seminiferous epithelium without any morphological alteration of the epididymis. In this study, we demonstrated the constitutive immunoexpression of inducible nitric oxide synthase (iNOS) in the testis and epididymis of Wistar rats treated with finasteride for 28 days (the duration of two cycles of the seminiferous epithelium) and 56 days (the duration of one spermatogenesis). We noted that a 56-day finasteride treatment mainly caused a decrease in the level of circulating DHT, as well as a statistically insignificant decrease in the level of T. The hormone deficiency also led to a change in the iNOS immnoexpression in the testis and epididymis of the finasteride-treated rats. In vitro, DHT did not modify NO production by the epithelial cells of the caput epididymis even when stimulated with LPS and IFNγ, but it did give rise to an increase in NO production by the epithelial cells of the cauda epididymis without the stimulation. DHT did not have a statistically significant influence on estradiol production by cultured, LPS- and IFNγ-stimulated epithelial cells from the caput and cauda epididymis. In conclusion, our data clearly indicates that a finasterideinduced DHT deficiency intensifies the constitutive expression of iNOS in most rat testicular and epididymal cells, so it can be expected that the expression of inducible nitric oxide synthase (iNOS) could be regulated by DHT. On the other hand, the profile of the circulating DHT and T levels strongly suggests that the regulation of constitutive iNOS expression is complex and needs more detailed study.

3

Immunolocalization of androgen receptor in the epididymis of rats with dihydrotestosterone deficiency

100%

Trybek G., Kolasa A., Marchlewicz M., Wenda-Rozewicka L., Wiszniewska B.

Reproductive Biology

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2005

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tom 05

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nr 3

4

Effect of low protein diet on the p-aminophenol level in the urine of rats exposed to aniline

100%

Florek E.

Acta Poloniae Toxicologica

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1996

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tom 04

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nr 1

5

Genetic analysis of erythrocyte AMP deaminase deficiency

100%

Ogasawara N., Yamada Y., Goto H.

Cellular and Molecular Biology Letters

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1999

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tom 04

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nr 3

6

Various types of hypophosphataemia in dairy cows and the clinical implications depending on the intensity of the deficiency

84%

Kurek L., Lutnicki K., Banach A.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 1

35-41

The paper aimed at defining the specific biochemical parameters, as well as the use of treatment methods, according to types and intensity of the clinical signs of non-complicated hypophosphataemia in cows. The investigations were carried out on 300 HF cows in 15 herds in the Lublin Region. The mean milk yield in the herds was 36.8 ±2.8 dl. The cows were 3-9 years old and had a similar diet ratio. The animals with hypophosphataemia symptoms in the early stadium (2-7 d) were divided into three groups according to the intensity of clinical signs whereas the control group consisted of cows with no clinical signs of the illness. The inorganic phosphorus (Pi), total Ca, total Mg, K, Fe, total protein, Cu, bilirubin, FFA, and creatinine concentrations, as well as AST and AP activity, were determined in serum and plasma. The animals with markedly exhibited signs (recumbency and tremor) showed significantly decreased Pi, Mg, and FFA contents and simultaneously increased activity of AST and AP. In the group exhibiting minimal signs (group I), there were no significant disturbances in homeostasis except the low Pi concentration, so it was possible to use the specialised phosphorus preparations in the treatment. In the other groups (II, III), which exhibited more marked signs of the illness, it was necessary to improve the parenchymal organs functions in addition to phosphorus level normalisation.

7

Clinical and immunological features of 78 adult patients with primary selective IgG subclass deficiencies

84%

Khokar A., Gupta S.

Archivum Immunologiae et Therapiae Experimentalis

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2019

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tom 67

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nr 5

8

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Effects of mineral deficiency on the health of young ruminants

84%

Radwinska J., Zarczynska K.

Journal of Elementology

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2014

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tom 19

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nr 3

Twenty-two elements have been identified as essential to the growth and health of animals. They include 7 macroelements and 15 microelements, which play four key functions in the body: structural, physiological, catalytic and regulatory. Mineral deficiencies can result from low quality feed, impaired absorption or assimilation in the body or increased demand for minerals during intensive growth, pregnancy and lactation. Mineral-deficient feed and diets with an unbalanced mineral content impair the growth and development of young animals, decrease appetite, lower nutrient absorption, decrease immunity and increase susceptibility to contagious diseases. This paper discusses the consequences of low levels of macronutrients and micronutrients that are required for the optimal growth of calves, lambs and kids, including calcium, phosphorus, magnesium, selenium, cobalt, iron, zinc, copper, sodium, potassium and chloride.

9

Molecular analysis of three novel G6PD variants: G6PD Pedoplis-Ckaro, G6PD Piotrkow and G6PD Krakow

84%

Maciag M., Plochocka D., Jablonska-Skwiecinska E., Mendek-Czajkowska E., Golaszewska E., Strojny W., Balwierz W., Zdebska E., Burzynska B.

Acta Biochimica Polonica

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2007

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tom 54

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nr 4

877-881

We present three novel mutations in the G6PD gene and discuss the changes they cause in the 3-dimensional structure of the enzyme: 573C→G substitution that predicts Phe to Leu at position 191 in the C-terminus of helix αe, 851T→C mutation which results in the substitution 284Val→Ala in the β+α domain close to the C-terminal part of helix αj, and 1175T→C substitution that predicts Ile to Thr change at position 392.

10

Copper deficiency in feedlot cattle

84%

Karapinar T., Dabak M., Demirci Y., Balikci E.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 1

This study was conducted on 25 animals randomly selected from a herd with 40 feedlot cattle, which had poor growth, rough hair coat, and change in the colour of the hair coat. Blood samples were collected from the vena jugularis into the tubes containing Na₂EDTA for the determination of plasma copper concentration and blood profile. Feed samples were also tested for copper, zinc, and molybdenum content. Ten healthy cattle were used as controls from different herds. In the affected group, mean plasma copper level was found to be at 6.43 µmol/L ± 0.01 and copper, molybdenum, and zinc levels in the diet were 15.55 ppm, 3.85 ppm, and 120 ppm, respectively. The mean plasma copper level in control animals was 13.50 µmol/L ±0.06). The difference was statistically significant (P<0.001). The deficiency of copper content may result from especially high molybdenum and zinc levels in the diet. When any finding indicative of this deficiency is observed in a herd, copper status of the animals should be determined. Then, copper and especially molybdenum and zinc concentration in the diet should be examined.

11

Effect of oxygen deficiency on the macroelement content of the soil [pot experiment with barley cv.Aramir vegetation]

84%

Wlodarczyk T., Stepniewski W., Stepniewska Z., Brzezinska M., Bennicelli R., Przywara G.

International Agrophysics

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2001

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tom 15

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nr 4

12

Deficiencies in the law of diminishing returns. Part I

84%

Szarek S.

Electronic Journal of Polish Agricultural Universities. Series Economics

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2005

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tom 08

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nr 3

In the paper there was presented an issue of the law of diminishing returns in agriculture. It was shown, that despite its general character, it is impossible to satisfactorily explain issues of input´s transformation into output in a farming process in agriculture.

13

Próby stressowego wywołania niedoboru metioniny i cystyny u szczurów dorosłych

67%

Konieczna W.

Roczniki Państwowego Zakładu Higieny

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1963

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tom 14

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nr 6

14

Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation

67%

Yan S.-J., Lee Y.-F., Ting H.-J., Liu N.-C., Liu S., Lin S.-J., Yeh S.-D., Li G., Chang C.

Cellular and Molecular Biology Letters

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2012

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tom 17

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nr 2

The testicular receptor 4 (TR4) is a member of the nuclear receptor superfamily that controls various biological activities. A protective role of TR4 against oxidative stress has recently been discovered. We here examined the protective role of TR4 against ionizing radiation (IR) and found that small hairpin RNA mediated TR4 knockdown cells were highly sensitive to IR-induced cell death. IR exposure increased the expression of TR4 in scramble control small hairpin RNA expressing cells but not in TR4 knockdown cells. Examination of IR-responsive molecules found that the expression of Gadd45a, the growth arrest and DNA damage response gene, was dramatically decreased in Tr4 deficient (TR4KO) mice tissues and could not respond to IR stimulation in TR4KO mouse embryonic fibroblast cells. This TR4 regulation of GADD45A was at the transcriptional level. Promoter analysis identified four potential TR4 response elements located in intron 3 and exon 4 of the GADD45A gene. Reporter and chromatin immunoprecipitation (ChIP) assays provided evidence indicating that TR4 regulated the GADD45A expression through TR4 response elements located in intron 3 of the GADD45A gene. Together, we find that TR4 is essential in protecting cells from IR stress. Upon IR challenges, TR4 expression is increased, thereafter inducing GADD45A through transcriptional regulation. As GADD45A is directly involved in the DNA repair pathway, this suggests that TR4 senses genotoxic stress and up-regulates GADD45A expression to protect cells from IR-induced genotoxicity.

15

Hormone concentration, metabolic disorders and immunoexpression of androgen and estrogen--alpha receptors in men with benign prostatic hyperplasia and testosterone deficiency syndrome

67%

Ryl A., Rotter I., Slojewski M., Dolegowska B., Grabowska M., Baranowska-Bosiacka I., Laszczynska M.

Folia Histochemica et Cytobiologica

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2015

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tom 53

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nr 3

16

Levels of selected biochemical indicators of serum and blood during subclinical forms of nutritional muscular dystrophy in lambs

67%

Sobiech P., Kuleta Z.

Polish Journal of Veterinary Sciences

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1999

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tom 02

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nr 1

Selenium level, and Ihe activity of GSH-Px, AST, CK, LDH and its isoenzymes were estimated in 30 lambs suspected of having the subclinical form of nutritional muscular dystrophy (NMD) and in 30 healthy lambs. A significant Se deficiency, a reduction in the activity of peroxidase glutathione, an increase in creatine kinase, aspartate aminotransferase and lactate dehydrogenase activities were found in the unhealthy lambs. Isoenzymatic profile of LDH showed 5 tractions. Tń the unhealthy lambs, there was a significant increase in LDH5 fraction-muscular isoenzyme, which is specific to the skeletal muscle. These indicators however, remained within a normal physiological range in the healthy lambs.

17

Lack of carriers of citrullinaemia and DUMPS in Indian Holstein cattle

67%

Patel R. K., Singh K. M., Soni K. J., Chauhan J. B., Sambasiva R. K. R. S.

Journal of Applied Genetics

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2006

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tom 47

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nr 3

The present study investigated the occurrence of 2 autosomal recessive genetic diseases, bovine citrullinaemia and deficiency of uridine monophosphate synthase (DUMPS), in Indian Holstein cattle. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed on a group of 642 animals, mainly HF and HF crossbred cattle, to identify carriers of these diseases. None of the animals were carriers of citrullinaemia or DUMPS. It is possible that with the mounting selection pressure, the international gene pool may diminish, and consequently the risk of dissemination of inherited defects will increase. It is therefore recommended to screen breeding bulls for their breed-specific genetic diseases before they are inducted in artificial insemination programmes, to minimize the risk.

Ograniczanie wyników

On the systemic approach to balance deficiency

The expression of inducible nitric oxide synthase [iNOS] in the testis and epididymis of rats with a dihydrotestosterone [DHT] deficiency

Immunolocalization of androgen receptor in the epididymis of rats with dihydrotestosterone deficiency

Effect of low protein diet on the p-aminophenol level in the urine of rats exposed to aniline

Genetic analysis of erythrocyte AMP deaminase deficiency

Various types of hypophosphataemia in dairy cows and the clinical implications depending on the intensity of the deficiency

Clinical and immunological features of 78 adult patients with primary selective IgG subclass deficiencies

Effects of mineral deficiency on the health of young ruminants

Molecular analysis of three novel G6PD variants: G6PD Pedoplis-Ckaro, G6PD Piotrkow and G6PD Krakow

Copper deficiency in feedlot cattle

Effect of oxygen deficiency on the macroelement content of the soil [pot experiment with barley cv.Aramir vegetation]

Deficiencies in the law of diminishing returns. Part I

Próby stressowego wywołania niedoboru metioniny i cystyny u szczurów dorosłych

Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation

Hormone concentration, metabolic disorders and immunoexpression of androgen and estrogen--alpha receptors in men with benign prostatic hyperplasia and testosterone deficiency syndrome

Levels of selected biochemical indicators of serum and blood during subclinical forms of nutritional muscular dystrophy in lambs

Lack of carriers of citrullinaemia and DUMPS in Indian Holstein cattle