Wyniki wyszukiwania

1

The correlation between NK cytotoxic activity and the production of the proinflammatory cytokines during the ageing process

100%

Bryl E., Mysliwska J., Foerster J., Mysliwski A.

Folia Histochemica et Cytobiologica

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1997

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tom 35

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nr 2

2

Protein kinase inhibitors arrested the in-vitro growth of Theileria equi

88%

Yadav J., Goel P., Mandal K. D., Yadav R., Kumar N., Kumar R., Tripathi B. N., Kumar S.

Acta Parasitologica

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2020

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tom 65

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nr 3

3

The susceptibility to apoptosis of natural killer [NK] cells in elderly individuals with low and high levels of NK cytotoxic activity

88%

Szmit E., Trzonkowski P., Mysliwska J., Mysliwski A.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr Suppl.

4

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Antiviral and cytotoxic activities of anthraquinones isolated from Cassia roxburghii Linn. leaves

75%

Mohammed M. M. D., El-Souda S. S., El-Hallouty S. M., Kobayashi N.

Herba Polonica

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2013

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tom 59

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nr 4

The cytotoxic activity of petroleum ether extract of the leaves of Cassia roxburghii Linn. against HCT-116 and MCF-7 cell lines resulted with IC50=34.9 and 38.04 μg/ml, respectively, while against HepG-2 showed no activity. A bioassay guided-fractionation approach was conducted to isolate and identify the active cytotoxic principles. Further chromatographic separation and purification of the petroleum ether extract resulted in the isolation of two anthraquinones identified as aloe-emodin acetate and aloe-emodin, along with stigmasterol, β-sitosterol and palmitic acid. The structure elucidation of isolated compounds was performend using 1D, 2D-NMR and HR-MS. Furthermore, the cytotoxicity of aloe-emodin acetate and aloe-emodin were evaluated and resulted with IC50=153.30 and 70.02 μg/ml against HCT-116 and with 93.20 and 53.20 μg/ml against MCF-7, respectively, while against HepG-2 showed no activity. Moreover, the antiviral activity of the two isolated anthraquinones was tested against influenza virus-A, and resulted with IC50=10.23 as well as 2.00 and with CC50=1.32 and 0.47 μg/ml, respectively.

5

Cytotoxic activity of Serratia marcescens clinical isolates

75%

Krzyminska S., Raczkowska M., Kaznowski A.

Polish Journal of Microbiology

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2010

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tom 59

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nr 3

Twenty Serratia marcescens isolates from clinical specimens were examined for their cytotoxic activity on four cell lines (HEp-2, Vero, CHO, J774). Most of the isolates were found to be cytotoxic to CHO (70%), Vero (75%) and HEp-2 cells (90%). CHO cells were the most sensitive to cell-free supematants, followed by HEp-2 and Vero cells. Two strains produced cytotonic toxins which caused elongation of CHO cells. Moreover, twelve isolates (60%) revealed cytotoxic potential to macrophage cell line J774. The results indicate that these bacteria may destroy phagocytes and epithelial cells, which may lead to spread within the host.

6

Interleukin 3-dependent, asialo-GM1-positive cell line with natural cytotoxic but without natural killer cytotoxic activity

75%

Strzadala L., Ziolo E., Matuszyk J.

Archivum Immunologiae et Therapiae Experimentalis

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1994

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tom 42

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nr 3

7

Cytotoxic and genotoxic activity of purine acyclic nucleotide analogs

75%

Otova B., Sladka M., Votruba I., Holy A., Schramlova J., Francova K.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

8

In silico and in vitro cytotoxic effect of prodigiosin-conjugated silver nanoparticles on liver cancer cells (HepG2)

63%

El-Batal A. I., El-Hendawy H. H., Faraag A. H. I.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2017

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tom 98

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nr 3

9

Chemical composition and cytotoxic activity of the polysaccharide fraction in Sarcodon imbricatus (Basidiomycota)

63%

Sulkowska-Ziaja K., Muszynska B., Ekiert H.

Acta Mycologica

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2012

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tom 47

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nr 1

The aim of the study was chemical analysis of polysaccharide fractions from sporocarps of Sarcodon imbricatus collected in natural sites and from the mycelium of in vitro cultures. Three polysaccharide fractions (FOI, FOII, FOIII) were isolated from sporocarps and two (FKI, FKII) from in vitro cultures. Qualitative analysis by HPLC method showed that they are composed of galactose and fucose (FOI, FKI) or glucose and fucose (FOII, FKII). FOIII fraction of the sporocarps consisted of glucose only. Molecular weights of isolated fractions ranged from 3.8 to 16.3 kDa for fractions from the sporocarps and from 5.8 to 14.7 kDa for that ones isolated from in vitro culture. The total percentage of sugar content for all fractions ranged from 97.8% to 99.1%. The percentage of uronic acids contents in acidic fractions was 2.6% and 2.7% for the FOI and FKI respectively. The work included also an assessment of cytotoxic activity of polysaccharide fractions in relation to tumor cell lines of human breast cancer MCV-7. FOI polysaccharide fraction of the sporocarps inhibited the growth of cancer cells in 50% compared to the control at a concentration of 0.0125%, while the polysaccharide fraction FKI from in vitro cultures inhibited cell growth in a concentration of 0.016%.

10

Application of genome editing techniques in immunology

63%

Zych A. O., Bajor M., Zagozdzon R.

Archivum Immunologiae et Therapiae Experimentalis

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2018

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tom 66

|

nr 4

11

Comparison of phenolic compounds, antioxidant and cytotoxic activity of extracts prepared from Japanese quince (Chaenomeles japonica L.) leaves

63%

Chojnacka K., Sosnowska D., Polka D., Owczarek K., Gorlach-Lira K., De Verasa B. O., Lewandowska U.

Journal of Physiology and Pharmacology

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2020

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tom 71

|

nr 2

12

Clinical and In vitro studies on impact of high-dose etoposide pharmacokinetics prior allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia on the risk of post-transplant leukemia relapse

63%

Sobiak J., Kazimierczak U., Kowalczyk D. W., Chrzanowska M., Styczynski J., Wysocki M., Szpecht D., Wachowiak J.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

|

nr 5

13

Isolation and in vitro cytotoxic activity of 11-methylixoside isolated from bark of Randia dumetorum Lamk.

63%

Jangwan J. S., Aquino R. P., Mencherini T., Singh R.

Herba Polonica

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2013

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tom 59

|

nr 1

Randia dumetorum (family Rubiaceae) is highly reputed ayurvedic medicinal tree commonly known as the Mainphal. A large deciduous thorny shrub grows up to 5 m of height. It occurs almost throughout India up to 1200 m of altitude. It is found in Himalaya from Jammu East ward ascending to 400 m and from Kashmir to East ward up to 1200 m. 11-methylixoside (compound 1), an iridoid glucoside, was isolated from the bark of this plant. The structure was characterized by using spectroscopic methods including 1D-1HNMR,13C-NMR and 2D-NMR (HSQC,HMBC, DQF-COSY) experiments and confirmed by comparison of their NMR data with those from the literature. This compound has been reported for the first time in Randia dumetorum bark. The 11-methylixoside was subjected to cytotoxic activity against MDA-MB-231 (breast cancer cell line) and SK-MEL-2 (human skin melanoma cell line), BE(2)C (neuroblastoma cell line derived from human bone marrow) and U87MG (human neuronale glioblastoma (astrozytom) cell line showed appreciable cytotoxic effect with IC50 value 63.10 µg/ml concentration for SK-MEL-2 (human skin melanoma cell line).

14

Antibacterial effect of an extract of the endophytic fungus Alternaria alternata and its cytotoxic activity on MCF-7 and MDA MB-231 tumour cell lines

63%

Arivudainambi E., Kanugula A. K., Kotamraju S., Karunakaran C., Rajendran A.

Biological Letters

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2014

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tom 51

|

nr 1

15

Bioactive metabolites produced by Spirulina subsalsa from the Baltic Sea

63%

Szubert K., Wiglusz M., Mazur-Marzec H.

Oceanologia

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2018

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tom 60

|

nr 3

16

Phytochemical characterization by GC-MS and in vitro evaluation of antiproliferative and antimigratory studies of Leucas aspera leaf extracts on MDA-MB-231 cell line

63%

Mahaboob Begum S.M. F., Sankarram M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2024

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tom 105

|

nr 1

17

L-proline analogues of anthraquinone-2-carboxylic acid as prolidase-activated prodrugs: cytotoxic activity in breast cancer MCF-7 cells and inhibitory activity against topoisomerase I and II

63%

Bielawska A., Bielawski K., Palka J., Kosk K.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

|

nr 1

18

The influence of liposome-encapsulated new MDP derivatives on the spleen NK cytotoxic activity and on the serum level of interleukin 2 [IL-2], interleukin 6 [IL-6], tumor necrosis factor-alpha [TNFalpha] and transforming growth factor-beta [TGFbeta] in the Bomirski melanoma bearing hamsters

63%

Sosnowska D., Mysliwski A., Szmit E., Szatkowski D., Dzierzbicka K., Kolodziejczyk A. M.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

19

Novel Ru[III], Rh[III], Pd[II] and Pt[II] complexes with ligands incorporating azole and pyrimidine rings. I. Antiproliferative activity in vitro

63%

Wisniewski M. Z., Wietrzyk J., Opolski A.

Archivum Immunologiae et Therapiae Experimentalis

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2000

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tom 48

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nr 1

20

Effect of captopril and thiorphan on the proliferation of human neoplastic cell lines and their influence on cytostatic activity of interferon alpha or cytotoxic activity of doxorubicin

63%

Kowalski J., Belowski D., Wielgus J., Gabryel B., Klin M., Herman Z. S.

Archivum Immunologiae et Therapiae Experimentalis

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1995

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tom 43

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nr 1

Ograniczanie wyników

The correlation between NK cytotoxic activity and the production of the proinflammatory cytokines during the ageing process

Protein kinase inhibitors arrested the in-vitro growth of Theileria equi