Wyniki wyszukiwania

1

Cystic fibrosis as a cause of infertility

100%

Jarzabek K., Zbucka M., Pepinski W., Szamatowicz J., Domitrz J., Janica J., Wolczynski S., Szamatowicz M.

Reproductive Biology

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2004

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tom 04

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nr 2

2

Cystic fibrosis is a risk factor for celiac disease

88%

Walkowiak J., Blask-Osipa A., Lisowska A., Oralewska B., Pogorzelski A., Cichy W., Sapiejka E., Kowalska M., Korzon M., Szaflarska-Poplawska A.

Acta Biochimica Polonica

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2010

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tom 57

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nr 1

115-118

Background: The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence of CD in CF patients to that in the general population at the same time. There is no published data on genetic predisposition to CD in CF patients either. Therefore, in the present study we aimed to assess the genetic predisposition to CD and its incidence in CF patients comparing it to data from the general population. Patients and methods: Two hundred eighty-two CF patients were enrolled in the study. In 230 CF patients the genetic predisposition to CD (the presence of HLA-DQ2/ DQ8) was assessed. In all CF patients, serological screening for CD was conducted. In patients with positive antiendomysial antibodies (EMA) gastroduenoscopy was offered. Intestinal histology was classified according to modified Marsh criteria. The results of serological CD screening in 3235 Polish schoolchildren and HLA-DQ typing in 200 healthy subjects (HS) were used for comparison. Results: Positive EMA was found in 2.84 % of the studied CF patients. The incidence of proven CD was 2.13 %. The incidence of CD as well as positive serological screening were significantly more frequent in the CF group than in the general population. The frequency of CD-related HLA-DQ alleles in CF and HS did not differ. Conclusions: Genetic predisposition to celiac disease in cystic fibrosis patients is similar to that of the general population. However, our results suggest that cystic fibrosis is a risk factor for celiac disease development.

3

The frequency of mutations in Exon 11 of the CF gene in Polish cystic fibrosis patients

88%

Bal J., Mazurczak T., Reiss J.

Acta Biochimica Polonica

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1992

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tom 39

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nr 3

Results of mutation analysis in exon II of the CF gene have been presented. Using the SSCI' technique 18 mutations (of four different types) were detected in cystic fibrosis patients of Polish origin. Thus, we were able to detect in exon 11 about 10% of all CF mutations occuring in the affected population examined.

4

Reappraisal of amiloride action on transepithelial electrical potential difference of isolated tracheal wall

88%

Tyrakowski T., Banach B., Moscibroda A., Bartlomowicz M., Wojciechowska M.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 1

5

Thiocyanate concentration in saliva of cystic fibrosis patients

75%

Minarowski L., Sands D., Minarowska A., Karwowska A., Sulewska A., Gacko M., Chyczewska E.

Folia Histochemica et Cytobiologica

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2008

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tom 46

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nr 2

245-246

6

Antibiotic therapy and fat digestion and absorption in cystic fibrosis

75%

Lisowska A., Pogorzelski A., Oracz G., Skorupa W., Cofta S., Szydlowski J., Socha J., Walkowiak J.

Acta Biochimica Polonica

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2011

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tom 58

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nr 3

Antibiotic therapy in the cystic fibrosis (CF) mouse model has been shown to result in reduced bacterial load of the intestine and significant body mass gain. The effect was suggested to be linked to the improvement of intestinal digestion and absorption. Therefore, we aimed to assess the influence of routinely applied antibiotic therapy in CF patients on fat assimilation. Twenty-four CF patients aged 6 to 30 years entered the study. Inclusion criteria comprised confirmed exocrine pancreatic insufficiency and bronchopulmonary exacerbation demanding antibiotic therapy. Exclusion criteria comprised: antibiotic therapy six weeks prior to the test, liver cirrhosis, diabetes mellitus, oxygen dependency, the use of systemic corticosteroids. In all enrolled CF subjects, 13C-labelled mixed triglyceride breath test (13C MTG-BT) was performed to assess lipid digestion and absorption, before and after antibiotic therapy. Sixteen subjects were treated intravenously with ceftazidime and amikacin, eight patients orally with ciprofloxacin. Cumulative percentage dose recovery (CPDR) was considered to reflect digestion and absorption of lipids. The values are expressed as means (medians). The values of CPDR before and after antibiotic therapy did not differ in the whole studied group [4.6(3.3) % vs. 5.7(5.3) %, p = 0.100] as well as in the subgroup receiving them intravenously [4.6(3.2) % vs. 5.7(5.3) %, p = 0.327] or in that with oral drug administration [4.6(3.4) % vs. 5.7(5.4) %, p = 0.167]. In conclusion, antibiotic therapy applied routinely in the course of pulmonary exacerbation in CF patients does not seem to result in an improvement of fat digestion and absorption.

7

Vitamin K status in cystic fibrosis patients

75%

Krzyzanowska P., Walkowiak J.

Acta Scientiarum Polonorum. Technologia Alimentaria

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2010

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tom 09

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nr 4

463-467

Abstract. Vitamin K belongs to the family of fat-soluble vitamins and plays an important role in hemostasis, bone metabolism and may affect cerebral sphingolipid synthesis. It is a cofactor necessary for posttranslational γ-carboxylation of glutamyl residues in selected proteins such as the osteocalcin, and procoagulation factors II, VII, IX, X. Vitamin K deficient individuals appear to have more undercarboxylated proteins, which are functionally defective. The witamin K deficiency has been frequently documented in patients with cystic fibrosis. The main possible causes of this deficiency include: fat malabsorption due to pancreatic exocrine insufficiency, cholestatic or noncholestatic liver disease, reduced production of vitamin K by colonic flora related to chronic antibiotic treatments, bowel resections and increased mucous accumulation in the bowel. CF patients are more prone to osteopenia, caused by chronic vitamin K shortage, than to coagulopathy. Despite available evidence, which strongly suggests that all CF patients are at risk for developing vitamin K deficiency, its supplementation doses have not been established. Recent recom- mendations from Europe and the UK have suggested varied doses ranging from 0.3 mg/day to 10 mg/week. Further studies, both cross sectional and longitudinal interventional, are still required to determine routine and therapeutic supplementation doses.

8

Relationship between nutritional status and pulmonary function in adult cystic fibrosis patients

75%

Gozdzik J., Cofta S., Piorunek T., Batura-Gabryel H., Kosicki J.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 6

253-260

9

Cellulase inhibits Burkholderia cepacia biofilms on diverse prosthetic materials

75%

Rajasekharan S. K., Ramesh S.

Polish Journal of Microbiology

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2013

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tom 62

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nr 3

Burkholderia cepacia is an opportunistic pathogen causing infections in patients with cystic fibrosis. Patients with implanted devices are prone to B. cepacia infections due to its ability to grow as biofilms. Knowing the importance of polysaccharides in a biofilm, enzymes that degrade them were targeted as a possible candidate for antibiofilm agents. In this study, the antibiofilm potential of cellulase against B. cepacia biofilms formed on various prosthetic materials was tested. Cellulase exhibited significant antibiofilm activity against B. cepacia without having much action on its growth, thus ruling out the chance of selection pressure and subsequent development resistance.

10

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Effect of genotype on selected clinical features of Polish cystic fibrosis adults

75%

Majka L., Pogorzelski A., Mlynarczyk W., Zebrak J., Rutkiewicz E., Nowicka A., Witt M.

Journal of Applied Genetics

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2001

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tom 42

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nr 3

11

Modified effect of the Toll-like receptor 4 D299G polymorphism in children with cystic fibrosis

75%

Urquhart D. S., Allen J., Elrayess M., Fidler K., Klein N., Jaffe A.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

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nr 4

12

Comparative phenotypic characteristics of Staphylococcus aureus isolated from cystic fibrosis patients versus blood and skin-mucosal infections isolates

75%

Sadowska B., Bonar A., Rzezniczak M., Solarska I., Rudnicka W., Rozalska B.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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2000

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tom 48

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nr 2

13

Toll-like receptor expression and function in airway epithelial cells

75%

Greene C. M., McElvaney N. G.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

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nr 5

14

Biological status of adult patients with cystic fibrosis

63%

Kosinska M., Szwed A., Cieslik J., Gozdzik J., Cofta S.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

|

nr 6

341-348

15

Characterization of Staphylococcus aureus strains isolated from cystic fibrosis patients by conventional and molecular typing

63%

Sadowska B., Cochard T., Poutrel B., Pytlos M., Bonar A., Gatkowska J., Rudnicka W., Polak J., Bielecki S., Siwinska-Golebiowska H., Rozalska B.

Acta Microbiologica Polonica

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2001

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tom 50

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nr 3-4

251-261

16

Inhalation of tobramycin in patients with cystic fibrosis: comparison of two methods

63%

Dopfer R., Brand P., Mullinger B., Hunger T., Haussermann S., Meyer T., Scheuch G., Siekmeier R.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

17

Small intestine bacterial overgrowth is frequent in cystic fibrosis: combined hydrogen and methane measurements are required for its detection

63%

Lisowska A., Wojtowicz J., Walkowiak J.

Acta Biochimica Polonica

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2009

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tom 56

|

nr 4

631-634

Introduction: Hydrogen breath test (BT) is commonly used as a diagnostic tool for the detection of small intestine bacterial overgrowth (SIBO). It was reported that colonic methane production is far more frequent in cystic fibrosis (CF) patients than in other subjects. Therefore, measuring exclusively hydrogen in the diagnostic breath test for diagnosing SIBO might be of limited value. We aimed to assess the usefulness of combined measurement of hydrogen and methane expiration for the diagnosis of SIBO in CF. Material and Methods: The study comprised 62 CF patients aged 5 to 18 years. Three-hundred-ninety subjects assessed due to gastrointestinal symptoms for the presence of SIBO served as a comparative group. In all subjects hydrogen/methane BT using glucose was performed. A positive BT was defined as fasting hydrogen ≥ 20 ppm or fasting methane ≥ 10 ppm or a rise of ≥ 12 ppm hydrogen or ≥ 6 ppm methane over baseline during the test. Results: In 23 (37.1%) CF patients and in 52 (13.3%) subjects from the comparative group abnormal BT results were found. In seven (11.3%) CF patients and 29 (7.4%) of the other subjects studied methane measurement allowed diagnosis of SIBO. Conclusions: Small intestine bacterial overgrowth is frequent in cystic fibrosis. For its detection in cystic fibrosis and other gastrointestinal patients, combined hydrogen and methane measurement instead of hydrogen breath test should be applied. Without the additional measurement of methane a significant percentage of SIBO will be missed.

18

The microbial endocrinology of Pseudomonas aeruginosa: inflammatory and immune perspectives

63%

Yong V. F. L., Soh M. M., Jaggi T. K., Aogain M. M., Chotirmall S. H.

Archivum Immunologiae et Therapiae Experimentalis

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2018

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tom 66

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nr 5

19

Occurrence of the nan1 gene and adhesion of Pseudomonas aeruginosa isolates to human buccal epithelial cells

63%

Wolska K., Kot B., Mioduszewska H., Sempruch C., Borkowska L., Rymuza K.

Biological Letters

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2012

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tom 49

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nr 1

20

The impact of hypertonic saline inhalation on mucociliary clearance and nasal nitric oxide

63%

Bencova A., Vidan J., Rozborilova E., Kocan I.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 3

Ograniczanie wyników

Cystic fibrosis as a cause of infertility

Cystic fibrosis is a risk factor for celiac disease

The frequency of mutations in Exon 11 of the CF gene in Polish cystic fibrosis patients

Reappraisal of amiloride action on transepithelial electrical potential difference of isolated tracheal wall

Thiocyanate concentration in saliva of cystic fibrosis patients

Antibiotic therapy and fat digestion and absorption in cystic fibrosis

Vitamin K status in cystic fibrosis patients

Relationship between nutritional status and pulmonary function in adult cystic fibrosis patients

Cellulase inhibits Burkholderia cepacia biofilms on diverse prosthetic materials

Effect of genotype on selected clinical features of Polish cystic fibrosis adults

Modified effect of the Toll-like receptor 4 D299G polymorphism in children with cystic fibrosis

Comparative phenotypic characteristics of Staphylococcus aureus isolated from cystic fibrosis patients versus blood and skin-mucosal infections isolates