Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 10

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  cyclic nucleotide
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
1

Hydrolysis cyclic GMP in rat peritoneal macrophages

100%
Witwicka H., Kobialka M., Gorczyca W. A.
Acta Biochimica Polonica
|
2002
|
tom 49
|
nr 4
Intact rat peritoneal macrophages (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. A PDE activity toward [3H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca2+ /calmodulin-independent but increased in the presence of cGMP excess. Similar results were obtained when3 [ 3H]cAMP was used as a substrate. The hydrolytic activity towards both nucleotides was inhibited in the presence of IBMX. Therefore, the PDEs of families 2,5,10 and 11 are potential candidates for cGMP hydrolysis in the rPM. They may not only regulate the cGMP level in a feedback-controlled way but also link cGMP-dependent pathways with those regulated by cAMP.
2

cGMP-dependent hydrolysis of cyclic nucleotides in peritoneal macrophages

100%
Wroblewska H., Kobialka M., Gorczyca W. A.
Cellular and Molecular Biology Letters
|
2002
|
tom 07
|
nr Suppl.
3

Detection of cyclic nucleotide phosphodiesterase mRNA in mouse skeletal muscle tissue and primary cultured myocytes

84%
Gu J. N., Chen W., Yu T. Q., Lu P., Mu X., Xu J. Q.
Journal of Animal and Feed Sciences
|
2007
|
tom 16
|
nr 4
696-705
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Thrombolytic and antiplatelet action of Xanthinol nicotinate [Sadamin]: possible mechanisms

84%
Bieron K., Swies J., Kostka-Trabka E., Gryglewski R. J.
Journal of Physiology and Pharmacology
|
1998
|
tom 49
|
nr 2
5

Cyclic nucleotide phosphodiesterases [PDEs] in human osteoblastic cells; The effect of PDE inhibition on cAMP accumulation

84%
Ahlstrom M., Pekkinen M., Huttunen M., Lamberg-Allardt C.
Cellular and Molecular Biology Letters
|
2005
|
tom 10
|
nr 2
6

Metabolism of cyclic GMP in peritoneal macrophages of rat and guinea pig

84%
Kobialka M., Witwicka H., Siednienko J., Gorczyca W. A.
Acta Biochimica Polonica
|
2003
|
tom 50
|
nr 3
The aim of our studies was to establish which enzymes constitute the "cGMP pathway" in rat and guinea pig peritoneal macrophages (PM). We found that in guinea pig PM synthesis of the nucleotide was significantly enhanced in response to activators of soluble guanylyl cyclase (sGC) and it was only slightly stimulated by specific activa­tors of particulate guanylyl cyclases (pGC). In contrast, rat PM responded strongly to atrial natriuretic peptide (ANP), the activator of pGC type A. The rat cells synthesized about three-fold more cGMP than an equal number of the guinea pig cells. The activity of phosphodiesterases (PDE) hydrolyzing cGMP was apparently regulated by cGMP itself in PM of both species and again it was higher in the rat cells than in those isolated from guinea pig. However, guinea pig PM revealed an activity of Ca2+ /cal- modulin-dependent PDE1, which was absent in the rat cells. Using Western blotting analysis we were unable to detect the presence of cGMP-dependent protein kinase 1 (PKG1) in PM isolated from either species. In summary, our findings indicate that particulate GC-A is the main active form of GC in the rat PM, while in guinea pig macrophages the sGC activity dominates. Since the profiles of the PDE activities in rat and guinea pig PM are also different, we conclude that the mechanisms regulating cGMP metabolism in PM are species-specific. Moreover, our results suggest that tar­gets for cGMP other than PKG1 should be present in PM of both species.
7

Ciliary and flagellar activity control in eukaryotic cells by second messengers: calcium ions and cyclic nucleotides

84%
Fabczak H., Walerczyk M., Sikora J., Fabczak S.
Acta Protozoologica
|
1999
|
tom 38
|
nr 2
8

Particulate guanylyl cyclases: multiple mechanisms of activation

84%
Kobialka M., Gorczyca W. A.
Acta Biochimica Polonica
|
2000
|
tom 47
|
nr 3
Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, is synthesized from GTP by a family of enzymes termed guanylyl cyclases, which are found in two forms: cytosolic (soluble) and membrane-bound (particulate). The past decade has brought significant progress in understanding the molecular mechanisms that underlie the regulation of particulate guanylyl cyclases and new members of their family have been identified. It has become more evident that the basic mechanism of catalysis of guanylyl cyclases is analogous to that recognized in adenylyl cyclases. Here we review the known basic mechanisms that contribute to the regulation of particulate guanylyl cyclases.
9

The cyclic nucleotide-IGF-I systems as possible mediator of effect of nutrition on ovarian activity in domestic nutria (Myocastor coypus)

67%
Sirotkin A., Mertin D., Suvegova K., Makarevich A., Genieser H.-G., Osadchuk L.
Zeszyty Naukowe. Przegląd Hodowlany
|
1999
|
tom 42
10

The cGMP synthesis and PKG1 expression in murine lymphoid organs

67%
Kurowska E., Kobialka M., Ziolo E., Strzadala L., Gorczyca W. A.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
tom 50
|
nr 4
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 1 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.