Wyniki wyszukiwania

1

Average quantitative concentration of cotinine within the system pregnant woman-baby

100%

Dobek D., Karmowski A., Sobiech K. A., Terpilowski L., Mis-Michalek M.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 1

2

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Salivary cotinine levels as a biomarker for green tobacco sickness in dry tobacco production among Thai traditional tobacco farmers

84%

Saleeon T., Siriwong W., Maldonado-Perez H. L., Robson M. G.

Roczniki Państwowego Zakładu Higieny

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2016

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tom 67

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nr 2

Background. Dry Thai traditional tobacco (Nicotiana Tabacum L.) production involves a unique process: (a) picking tobacco leaves, (b) curing tobacco leaves, (c) removing stems of tobacco leaves, cutting leaves and putting on a bamboo rack, (d) drying in the sun, reversing a rack, spraying a tobacco extract to adjust the tobacco’s color, storing dried tobacco and packaging. These processes may lead to adverse health effects caused by dermal absorption of nicotine such as Green Tobacco Sickness (GTS). Objectives. The aim of this study was to determine the correlation between GTS resulting from dry Thai traditional tobacco production and salivary cotinine levels among Thai traditional tobacco farmers in Nan Province, Thailand. Materials and Methods. A prospective cohort study was conducted with 20 tobacco farmers and 20 non-tobacco farmers in Praputtabath Sub-District and Phatow Sub-District. The participants were randomly selected and interviewed using in person questionnaires with bi-weekly follow-up for 14 weeks. During each contact, the cotinine concentration was measured by NicAlertTM Saliva strip tests (NCTS). Descriptive statistics and Spearman’s correlation (Spearman’s rho) was used to examine the relationship between the variables at both 0.01 and 0.05 significant probability levels. Results. This study indicated that GTS from dry tobacco production has the potential to be considered a common occupational disease. This study demonstrated the usefulness of salivary cotinine level measurements by NCTS. The levels were well correlated with farmers who were employed in the dry Thai tobacco production industry. Salivary cotinine levels were also significantly correlated with the prevalence of GTS in the group of tobacco farmers at any given time within a crop season. However, the production process of dry Thai traditional tobacco is different from that evaluated in our previous studies where GTS and salivary cotinine level were correlated in workers working in humid conditions. Conclusions. The long-term effects of such exposure should be investigated and health education programs with health risk exposure studies to increase awareness amongst farmers is recommended.

3

Combined SPE and HPTLC as a screening assay of urinary cotinine from male adolescents exposed to environmental tobacco smoke

84%

Bazylak G., Brozik H., Sabanty W.

Polish Journal of Environmental Studies

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2000

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tom 09

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nr 2

Cotinine, as the main metabolite of nicotine, has been determined in urine using solid-phase extraction and the high-performance thin-layer chromatographic (SPE-HPTLC) method. The urine samples were collected from a group of 35 male adolescents which were moderate or significantly exposed to home environmental tobacco smoke (ETS). l-methyl-2-pyrrolidinone was used as the internal standard in the proposed screening procedure. The thin-layer chromatograms were evaluated densitometrically after visualization of cotinine spots with ninhydrin and cadmium acetate solution. The described SPE-HPTLC procedure indicated good selectivity, sensitivity and reproducibility, enabling reliable verification of interview collected questionnaire data in families exhibiting a diversified level of ETS. The results of cotinine measurements by the proposed method were applied for assessment of hazards from home ETS on the health status of elementary schoolboys, especially an increased risk for infectious respiratory tract diseases and exercise-induced bronchospasm.

4

Effect of maternal tobacco smoking or exposure to second-hand smoke on the levels of 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanol (NNAL) in urine of mother and the first urine of newborn

67%

Florek E., Piekoszewski W., Basior A., Merriti A. T., Mazela J., Lechowicz W., Kornacka M. K., Kramer L.

Journal of Physiology and Pharmacology

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2011

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tom 62

|

nr 3

Tobacco smoking during pregnancy is associated with a variety of negative consequences not only for the mother, but also for the developing fetus. Many studies have shown that carcinogens contained in tobacco smoke permeate across the placenta, and are found in fetus. The aim of the study was to determine the prenatal exposure to tobacco-specific carcinogenic N-nitrosamines on the basis of measurements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine of smoking and second-hand smoke (SHS) exposed women and in the first urine of their newborns. A questionnaire documenting demographics and socio-economical data, smoking habits and exposure to SHS was completed by 121 delivering women near or at term. Maternal concentrations of cotinine and NNAL were measured in urine of the mother and the first urine of her newborn infant by liquid chromatography tandem mass spectrometry (LC/MS/MS). The mean concentration of cotinine was 439.2 ng/mg creatinine and NNAL concentration in urine of smoking women was 74.0 pg/mg creatinine, and for her newborn 78.6 pg/mg creatinine. Among mothers exposed to SHS, cotinine and NNAL mean concentration were 23.1 ng/mg creatinine, and 26.4 pg/mg creatinine. In newborns of SHS exposed mothers during pregnancy the mean concentration of NNAL was 34.1 pg/mg creatinine, respectively. Active tobacco smoking as well as passive exposure to smoking during pregnancy is an important source of tobacco specific N-nitrosamines to the fetuses as evidenced by increased concentrations of this carcinogen. Determination of NNAL in maternal urine samples can be a useful biomarker of prenatal exposure of newborn to carcinogenic nitrosamines.

5

An assessment of the selected morphometric parameters and levels of nicotine and cotinine in placentae of smoking mothers

67%

Wielgus E., Celinski R., Pawlicki K., Sybirska H., Kaminski M.

Acta Toxicologica

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2003

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tom 11

|

nr 2

6

Clinical pharmacology of eicosanoids, nicotine induced changes in man

67%

Saareks V., Riutta A., Alanko J., Ylitalo P., Parviainen M., Mucha I., Sievi E., Vapaatalo H.

Journal of Physiology and Pharmacology

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2000

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tom 51

|

nr 4,1

7

Effect of smoking on concentrations of cadmium, copper, iron and zinc in early transitional human milk

59%

Milnerowicz H., Chmarek M.

Acta Toxicologica

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2003

|

tom 11

|

nr 2

8

Kotynina w ocenie aktywnego i biernego palenia tytoniu przez kobiety rodzace

51%

Florek E., Piekoszewski W., Rybakowski L., Wrzosek J.

Roczniki Państwowego Zakładu Higieny

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2003

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tom 54

|

nr Supl.

34-36

Ograniczanie wyników

Average quantitative concentration of cotinine within the system pregnant woman-baby

Salivary cotinine levels as a biomarker for green tobacco sickness in dry tobacco production among Thai traditional tobacco farmers

Combined SPE and HPTLC as a screening assay of urinary cotinine from male adolescents exposed to environmental tobacco smoke

Effect of maternal tobacco smoking or exposure to second-hand smoke on the levels of 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanol (NNAL) in urine of mother and the first urine of newborn

An assessment of the selected morphometric parameters and levels of nicotine and cotinine in placentae of smoking mothers

Clinical pharmacology of eicosanoids, nicotine induced changes in man

Effect of smoking on concentrations of cadmium, copper, iron and zinc in early transitional human milk

Kotynina w ocenie aktywnego i biernego palenia tytoniu przez kobiety rodzace