Wyniki wyszukiwania

1

Attentional functions of the thalamic reticular nucleus in the rat

100%

Brown V. J., Petrof I.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

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nr 5

2

Ultrastructural studies of potato plants infected with PVY NTN

100%

Garbaczewska G., Chrzanowska M., Kerlan C.

Biological Bulletin of Poznań. Supplement

|

1997

|

tom 34

3

Hemispheric asymmetry in stimulus size evaluation

86%

Szatkowska I., Grabowska A., Nowicka A.

Acta Neurobiologiae Experimentalis

|

1993

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tom 53

|

nr 1

4

Comparison of the kinetic properties of the pyruvate dehydrogenase complex from pig kidney cortex and medulla

86%

Pawelczyk T., Olson M. S.

Acta Biochimica Polonica

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1993

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tom 40

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nr 3

The activity of the pyruvate dehydrogenase complex (PDC) purified from pig kidney medulla was affected by K+, Na+, CI", HCO3"", HP042" and changes in ionic strength. Increased ionic strength influenced the activity of PDC from medulla by decreasing the Vmax and S0.5 for pyruvate and increasing the Hill coefficient. The magnitude of these changes was smaller than the corresponding changes for PDC purified from the cortex. In the presence of K+ (80 mM), Na+ (20 mM), Cl~ (20 mM), HCO3" (20 mM), HPO42" (10 mM) and at ionic strength of 0.15 M the S0.5 for pyruvate of PDC from medulla was 117 nM and the enzyme complex was saturated by 1.1 mM pyruvate. Under these conditions the S0.5 for pyruvate of PDC derived from cortex was 159 nM and the enzyme was saturated at 4.5 mM pyruvate.

5

Effects of unilateral somatosensory cortex lesion upon locomotion in dogs

86%

Blaszczyk J. W., Dobrzecka C.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 2

6

Towards understanding of the role of transcription factors learning processes

86%

Kaczmarek L.

Acta Biochimica Polonica

|

1995

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tom 42

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nr 2

Recent advances in application of molecular biology to studies on learning and memory formation suggest that understanding of these seemingly elusive phenomena may be within our reach. This mini-review summarizes the present knowledge on activation and possible functions of transcription factors in learning processes with a focus on studies performed in the author's laboratory.

7

Categorical processing of continuous dimensions in inferotemporal cortex

72%

Jagadeesh B.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

|

nr 5

8

Choosing the greater of two goods: neural correlates of value based decision making

72%

Sugrue L. P., Corrado G. S., Newsome W. T.

Acta Neurobiologiae Experimentalis

|

2005

|

tom 65

|

nr 5

9

Metabotropic glutamate receptors and the control of the TRN input to thalamocortical neurones in vitro and in vivo

72%

Salt T. E.

Acta Neurobiologiae Experimentalis

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2005

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tom 65

|

nr 5

10

Memantine up-regulates nicotinic acetylcholine receptors expression in the cortex and sub-cortical white matter of aging rat brain

72%

Polrolniczak A., Rozycka A., Helias-Rodzewicz Z., Kempisty B., Grzelak T., Ziemnicka K., Steinborn B., Jagodzinski P. P., Dorszewska J.

Acta Neurobiologiae Experimentalis

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2013

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tom 73

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nr 1

Memantine (MEM) is a potent open channel blocker of N-methyl-Daspartate receptors (NMDARs), and primary has been developed for treatment of neuropathic pain, symptoms of dementia and AD. On the other hand, MEM is able to act as an open channel blocker on several other ligand gated ion channels, e.g., the α4β2 and α7 nicotinic acetylcholine receptors (nAChRs). The aged-related decline in the nAChRs expression could be associated with other senescence markers, such as increased oxidative stress leading to oxidative DNA changes (high level of 8-oxo-2’dG), accompanied with significant decrease in level of the OGG1 protein involved in DNA repair process. To study whether MEM treatment might influence on the α7 and α4 nAChRs expression in the aging rat brain tissues, we analyzed RNA and protein levels by RQ-PCR and Western blot validation in three brain structures: cerebral grey matter (CGM), sub-cortical white matter (SCWM) and cerebellum (Ce) of twenty one female Wistar rats. The animals were divided into following experimental groups: the first group consisted of five 3.0–3.5-month-old females, which was assigned as a young control group, and the remaining sixteen females aged of 18–24 month were divided into three following sub-groups: (1) aged control group of 5 rats; (2) a vehicle group of 5 rats which received intraperitoneal injections of deionized water (3) memantine-treated group of 6 rats. In each group, the selected brain areas have also been analyzed to determinate the levels of oxidative stress. In CGM and SCWM brain structures the level of 8-oxo-2’dG was significantly reduced in old rats after MEM administration (CGM P=0.05; SCWM P<0.05). Western blot analysis has also revealed a significant up-regulation of OGG1 level in CGM after MEM administration (CGM P=0.05). MEM specifically up-regulated mRNA level of cortical α4 subunit in the CGM region of aging rat brain (CGM, P<0.05). In the sub-cortical white matter an important increase of α7 mRNA level has been observed after MEM administration (SCWM P<0.05). The level of α7 nAChR protein was significantly up-regulated also in CGM and Ce regions of MEM treated rats (SCWM P=0.05; CGM P<0.05; Ce P<0.05). We demonstrated that processes related to aging, such as a decreases in OGG1 and nAChRs expression can be modified after memantine administration: (1) A significant increase in the CGM of α4 and α7 subunits, as well as up-regulated α7 level in the SCWM after MEM administration suggests that nAChRs play an important role in compensatory mechanisms facilitating the impaired cholinergic neurotransmission following treatment with MEM. (2) MEM significantly up-regulates cortical OGG1 protein expression and reduces the level of 8-oxo-2’dG in CGM. (3) A significant increase in both mRNA and protein levels of α7 nAChR along with reduction of 8-oxo-2’dG in SCWM, following treatment with MEM, suggests that the effect of MEM on cholinergic function may be associated with antioxidant mechanisms. Whether these protective effects of MEM are direct or are mechanistically remote from NMDARs antagonism, have to be evaluated in the further studies.

11

Projections of the claustrum to some areas of the neocortex in the rat - an HRP study

72%

Morys J., Sloniewski P.

Folia Morphologica

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1986

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tom 45

|

nr 3

12

Effects of two barbiturates, pentobarbital and phenobarbital on the C AMP - dependent phosphorylation of synapsin IA and IB in synaptosomal membranes of the rat cortex

72%

Podkul T., Lachowicz L.

Biophysics of Membrane Transport

|

1994

|

tom 12

|

nr 2

13

Calcium effect on the synthesis of lysine and arginine containing proteins in cortex cells of pea [Pisum sativum L.] root meristem treated with toxic metals

72%

Gabara B., Krajewska M.

Biological Bulletin of Poznań. Supplement

|

1996

|

tom 33

14

Cortical responsiveness is reduced during P300 potential. Does the level of initial activity affect this inhibition?

72%

Milner R., Michalski A.

Acta Neurobiologiae Experimentalis

|

2003

|

tom 63

|

nr 4

15

Cytological and histological investigations on the development of ovaries in white rats

72%

Zolnowska T., Sopinski M., Fortak W.

Acta Biologica Cracoviensia. Series Botanica et Zoologia. Supplement

|

1997

|

tom 39

|

nr 1

16

Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions

72%

Schwendt M., Jezova D.

Journal of Physiology and Pharmacology

|

2001

|

tom 52

|

nr 4,2

In addition to the central nervous system, glutamate receptors have been recently identified in a number of peripheral tissues, including adrenals. Pharmacological evidence indicates that adrenal glutamate receptors may be involved in stress response, particularly in catecholamine release. However, possible stress-induced changes at the level of local receptors themselves have not been evaluated yet. This study was aimed to investigate gene expression of N-methyl-D-aspartate (NMDA) receptor subunits (NR1, NR2A, NR2B) in rat adrenal gland under basal and stress conditions, using RT-PCR. NR1 mRNA was found to be present in the adrenal gland, while mRNAs coding for NR2-type subunits failed to be detected in adrenal tissue. The distribution of NR1 mRNA in rat adrenals showed higher concentrations in the adrenal medulla (228%) compared to those in the cortex. Single stress stimulus (immobilization) induced a significant increase of NR1 gene expression in both medullar (by 25%) and cortical (by 66%) regions of the adrenal gland at 24 h, while no changes were observed at 3 h after the stress exposure. It is possible that delayed rise in adrenal NR1 gene expression following stress exposure represents one of the factors by which stress exerts long-term effects on adrenal function at the molecular level.

17

Sclerification in the bark tissues of common fir [Abies alba Mill.]

72%

Janakowski S., Golinowski W.

Acta Societatis Botanicorum Poloniae

|

2000

|

tom 69

|

nr 1

18

Na,K-ATPase activity of rabbit kidney cortex membranes in ischemia and reperfusion

72%

Aydin S., Aricioglu A., Turkozkan N., Bingol F., Aydin C.

Acta Biochimica Polonica

|

1993

|

tom 40

|

nr 4

The activity of Na+,K*-ATPase in the microsomal fraction of rabbit kidney cortex was strongly decreased by ischemia and increased slightly, but not significantly, after reperfusion. These changes were correlated with a dramatic increase in lipid peroxidation in microsomes isolated from both ischemic and reperfused kidneys. This correlation may point to irreversible impairment of the enzymatic function under the influence of either oxygen free radicals or lipid peroxidation.

19

The ultrastructure of the somatic and oral cortex of the karyorelictean ciliate Loxodes striatus

72%

Klindworth T., Bardele C. F.

Acta Protozoologica

|

1996

|

tom 35

|

nr 1

20

The contralateral impairment of the orienting ocular-following reflex after lesions of the lateral suprasylvian cortex in cats

72%

Zernicki B., Stasiak M.

Acta Neurobiologiae Experimentalis

|

1994

|

tom 54

|

nr 4

Ograniczanie wyników

Attentional functions of the thalamic reticular nucleus in the rat

Ultrastructural studies of potato plants infected with PVY NTN

Hemispheric asymmetry in stimulus size evaluation

Comparison of the kinetic properties of the pyruvate dehydrogenase complex from pig kidney cortex and medulla

Effects of unilateral somatosensory cortex lesion upon locomotion in dogs

Towards understanding of the role of transcription factors learning processes

Categorical processing of continuous dimensions in inferotemporal cortex

Choosing the greater of two goods: neural correlates of value based decision making

Metabotropic glutamate receptors and the control of the TRN input to thalamocortical neurones in vitro and in vivo

Memantine up-regulates nicotinic acetylcholine receptors expression in the cortex and sub-cortical white matter of aging rat brain

Projections of the claustrum to some areas of the neocortex in the rat - an HRP study

Effects of two barbiturates, pentobarbital and phenobarbital on the C AMP - dependent phosphorylation of synapsin IA and IB in synaptosomal membranes of the rat cortex

Calcium effect on the synthesis of lysine and arginine containing proteins in cortex cells of pea [Pisum sativum L.] root meristem treated with toxic metals

Cortical responsiveness is reduced during P300 potential. Does the level of initial activity affect this inhibition?

Cytological and histological investigations on the development of ovaries in white rats

Gene expression of NMDA receptor subunits in rat adrenals under basal and stress conditions

Sclerification in the bark tissues of common fir [Abies alba Mill.]

Na,K-ATPase activity of rabbit kidney cortex membranes in ischemia and reperfusion

The ultrastructure of the somatic and oral cortex of the karyorelictean ciliate Loxodes striatus

The contralateral impairment of the orienting ocular-following reflex after lesions of the lateral suprasylvian cortex in cats