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The role of focal adhesion kinase in the emigration of cells from confluent cultures

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Trembacz H., Miloszewska J., Szaniawska B., Malecki M., Przybyszewska M., Skorski T., Janik P.

Cellular and Molecular Biology Letters

2002

tom 07

nr 4

We studied the effect of the modification of focal adhesion kinase (FAK) on the growth, migration and adhesion of C3H 10T1/2 cells. Cells transfected with plasmid coding for antisense FAK displayed a low level of FAK protein. Interestingly, the transfected cells achieved a higher saturation density at confluence, and displayed reduced adhesion and enhanced emigration from a confluent layer of cells when stimulated with fibronectin. In conclusion, it can be postulated that FAK plays an important role in the mechanism of contact inhibition.

Ograniczanie wyników

1 Cellular and Molecular Biology Letters

1 Janik P.

1 Malecki M.

1 Miloszewska J.

1 Przybyszewska M.

1 Skorski T.

1 Szaniawska B.

1 Trembacz H.

1 2002

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The role of focal adhesion kinase in the emigration of cells from confluent cultures