Wyniki wyszukiwania

1

Padma 28 - review of clinical studies

100%

Loniewski I., Samochowiec L.

Herba Polonica

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2004

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tom 50

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nr 3-4

Padma 28 is a combination of Tibetan herbs that is very often used in the western medicine. The present standard of modern phytotherapy requires controlled clinical studies to determine the therapeutic value of herbal preparation. In our review we present controlled clinical studies of Padma 28 in patients with intermittent claudication, juvenile chronic arthritis, multiple sclerosis and angina pectoris. In all the studies safety and tolerability levels were very high. We try also to discuss possible mechanisms of activity of this herbal product.

2

Experimental studies as an inspiration for clinical investigation

75%

Malecka-Panas E., Talar-Wojnarowska R., Kotynia J., Majumdar A. P. N.

Journal of Physiology and Pharmacology. Supplement

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2004

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tom 55

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nr 2

139-150

This study represents an attempt of showing own author's example of using basic research data as an inspiration for the clinical studies. The project evaluates the role of gastrin in colorectal carcinogenesis as well as the differences of its action in proximal and distal colon. Colonocytes were isolated from Fischer-344 rats and incubated for 2 minutes with gastrin (10-8M). This treatment resulted with 60-70% rise in tyrosine kinase (Tyr-k) and 150-200% - in phospholipase C activity as regards to basal levels. In vivo infusion of gastrin for 5 days to Fischer-344 rats resulted with 90-150% increase in distal but not proximal colonic mucosal proliferative activity as well as tyrosine phosphorylation of several colonic mucosal proteins. In clinical study, the mean fasting gastrin level in the control group was significantly lower (p<0.01) than in patients with colorectal cancer before surgery. Mean plasma gastrin level in patients with distal tumor yielded 105,31 ± 12,5 µ U/l and was significantly higher than in patients with the proximal tumor site (42, 2 ± 3,1 µU/l) (p<0,001). We conclude, that Tyr-k is involved in the mechanism of the trophic action of gastrin, particularly in distal colon. The differences in gastrin concentration in patients with distal and proximal tumors may probably contribute to the distinct pathogenesis and biological properties of those cancers.

3

Clinical and research ethics as moral strangers

75%

Kottow M. H.

Archivum Immunologiae et Therapiae Experimentalis

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2009

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tom 57

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nr 3

157-164

4

Agricultural medical survey - a joint project in Egypt

75%

Emara M. F.

Annals of Agricultural and Environmental Medicine

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1994

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tom 01

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nr 2

5

Analysis of the specificity and selectivity of anti-EpCAM antibodies in breast cancer cell lines

63%

Sterzynska K., Kempisty B., Zawierucha P., Zabel M.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 4

6

New European rules regarding the approval of clinical trials, the role of Ethics Committees and the Protection of Subjects

63%

Nys H.

Archivum Immunologiae et Therapiae Experimentalis

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2012

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tom 60

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nr 6

7

Changing perspectives in veterinary epidemiology

63%

Thrusfield M.

Polish Journal of Veterinary Sciences

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2001

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tom 04

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nr 1

8

Advance directives and the concept of competence: are they a moral barrier to resuscitation?

63%

Niebroj L. T.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

9

Mycobacteriosis in peafowl: analysis of four cases

63%

Ledwon A., Augustynowicz-Kopec E., Parniewski P., Bonecka J., Ostrzeszewicz M., Dolka B., Szeleszczuk P.

Medycyna Weterynaryjna

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2018

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tom 74

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nr 12

Peafowl (Pavo cristatus), similarly to other Galliformes, are particularly susceptible to infection by Mycobacterium avium. Peafowl differ from other Galliformes in the clinical image of the infection, with dominating respiratory signs. Occurrence of severe and sustained dyspnoea in peafowl raises suspicion of mycobacteriosis, which, however, is not always easy to confirm. In the cases described here, mycobacteria were detected in direct swabs from the trachea of two individuals, and cultures were conducted on the Löwenstein-Jensen medium. In one individual, no mycobacteria were found in tracheal swabs stained by the Ziehl-Neelsen method, despite the presence of clear clinical signs. The fourth case was a young bird submitted for necropsy. The cause of death was a mechanical trauma, but scarce caseous nodules typical of mycobacteriosis were found in the liver, spleen and lungs. The Mycobacterium avium isolates obtained from those cases were compared using (CCG)4-based PCR. A high similarity of three isolates of Mycobacterium avium subsp. avium was observed, two of which were derived from peafowl originating from the same farm, while the isolate from the fourth bird differed significantly and was identified by sequencing as Mycobacterium avium subsp. paratuberculosis.

10

How to select study designs and parameters to investigate the effect of mouthrinses? Part II: Comparisons between the parameters used

63%

Lorenz K., Bruhn G., Heumann C., Hoffmann T., Netuschil L.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 8

85-90

11

Osłuchiwanie układu oddechowego przeżuwaczy

63%

Bednarski M., Bednarska M., Szpilczynska-Ciesielska

Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii

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2018

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tom 13

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nr 1

12

Growth factor gene delivery for Alzheimer's disease: from animal models to clinical trials

63%

Tuszynski M., Nagahara A., Schroeder B., Coppola G., Wang L., Blesch A., Rockenstein E., Geschwind D., Masliah E., Koo E., Chiba A.

Acta Neurobiologiae Experimentalis

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2009

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tom 69

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nr 3

Nervous system growth factors have extensive effects on neuronal function and survival. Nerve growth factor (NGF) prevents the death and stimulates the function of basal forebrain cholinergic neurons in correlational models of Alzheimer’s disease (AD), leading to its translation to Phase 1 and 2 human clinical trials. Separately, Brain-Derived Neurotrophic Factor (BDNF) infl uences the survival and function of entorhinal cortical and hippocampal neurons in several animal models of AD, including transgenic mutant APP-expressing mice; aged rats and lesioned rats; and aged and lesioned primates. These benefi cial effects appear to occur independent of alteration in beta amyloid load. We are currently examining the extended safety and tolerability of BDNF gene delivery to the entorhinal cortex in additional animal studies, potentially leading to specifi c targeting of short term memory loss in future human AD trials. This talk will review the history and current status of growth factor gene delivery in AD and other neurodegenerative disorders.

13

Seroprevalence, clinical, and pathological characteristics of canine leishmaniasis in a central region of Colombia

63%

Picon V., Almario G., Rodriguez V., Garcia N. V.

Journal of Veterinary Research

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2020

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tom 64

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nr 1

14

Canine hip dysplasia of selected breeds - results obtained by two Polish clinics based on radiological examination conducted in 1997-2006

63%

Aleksiewicz R., Budzinska Z., Nowicki M., Adamiak Z., Lisiecka B.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 2

139-142

Canine Hip Dysplasia (CHD) is still a significant health problem among dogs of so called predisposed breeds where this disease is revealed even among 30% individuals of the whole population. The present results were obtained by two clinics and deal with CHD occurrence among the most frequently and predisposed breeds in Olsztyn and Siemianowice Śląskie/ Upper Silesia, Poland. Radiographs of hip joints were described using Riser's method. Altogether 2279 dog were examined including 2113 animals which were analysed. The German Shepherd Dog was the prevalent breed found in both clinics, but CHD was not common in this breed. In the Olsztyn Clinic, the most numerous group affected by CHD was Neapolitan Mastiff (60%), while in the Siemianowice Slaskie Clinic, dysplasia dominated in Bernese Mountain Dog (46%).

15

Human melanoma gene therapy: from animal studies to clinical trials

63%

Mackiewicz A., Kapcinska M., Laciak M., Malicki J., Murawa P., Nowak J., Sibilska E., Wiznerowicz M., Breborowicz D., Lange A., Hawley R. G., Heinrich P. C., Rose-John S.

Biotechnologia

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1996

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nr 4

16

Treating autoimmune diseases through restoration of antigen-specific immune tolerance

63%

Wolfraim L. A.

Archivum Immunologiae et Therapiae Experimentalis

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2006

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tom 54

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nr 1

17

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

The occurrence and allergising potential of airborne pollen in West Bengal, India

63%

Boral D., Chatterjee S., Bhattacharya K.

Annals of Agricultural and Environmental Medicine

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2004

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tom 11

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nr 1

A continuous 2-year volumetric aerobiological survey was conducted in Berhampore town, a centrally located and representative part of West Bengal, India. The aim of the study was to assess the allergising potential of airborne pollen grains of West Bengal. A total of 31 pollen types were identified of which Poaceae (grasses) pollen showed maximum frequency, followed by Cyperaceae, Cassia sp., Acacia auriculiformis, etc. The seasonal periodicities of the pollen types and their relationship to meteorological conditions were investigated. It was found that the pollen concentration is positively correlated with temperature and negatively correlated with rainfall and relative humidity. Clinical investigations by skin prick test were carried out to detect allergenicity of pollen types. Eighteen common airborne pollen types induced positive responses of which pollen extracts of Saccharum officinarum (grass), Azadirachta indica, Cocos nucifera, Phoenix sylvestris, Cyperus rotundus and Eucalyptus citriodora showed strongest sensitising potential. This result is consistent with previous investigations in different parts of West Bengal.

18

Thymic peptides and preparations: an update

63%

Cordero O. J., Pineiro A., Nogueira M.

Archivum Immunologiae et Therapiae Experimentalis

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1999

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tom 47

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nr 2

19

Infiltrative form of a tumour in cardiac base in a dog with dilated cardiomyopathy: clinical and morphological correlations. A case report

63%

Nowak M., Noszczyk-Nowak A., Mroz K., Dziegiel P.

Bulletin of the Veterinary Institute in Puławy

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2008

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tom 52

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nr 3

The case of a 12-year-old boxer dog, with an infiltrating tumour in cardiac base and dilated cardiomyopathy was described. Morphological and biochemical examinations of the blood, ECG, and USG of the heart were performed. In the resting ECG record, atrial fibrillation was detected with rapid action of ventricles. Echocardiography demonstrated distension of all cardiac cavities and a decreased contractility of the left ventricular myocardium. Despite intense treatment, the condition of the dog deteriorated: anaemia and renal insufficiency appeared and asphyxia intensified. At the owners' request, the dog was subjected to euthanasia. On autopsy, a tumour in the cardiac base was detected, which infiltrated the left atrial wall. Histopathology and immunohistochemistry permitted to diagnose neoplastic hypertrophy of chemodectoma type.

20

Clinical trials using autologous bone marrow and peripheral blood-derived progenitor cells in patients with acute myocardial infarction

63%

Tendera M., Wojakowski W.

Folia Histochemica et Cytobiologica

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2005

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tom 43

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nr 4

Ograniczanie wyników

Padma 28 - review of clinical studies

Experimental studies as an inspiration for clinical investigation

Clinical and research ethics as moral strangers

Agricultural medical survey - a joint project in Egypt

Analysis of the specificity and selectivity of anti-EpCAM antibodies in breast cancer cell lines

New European rules regarding the approval of clinical trials, the role of Ethics Committees and the Protection of Subjects

Changing perspectives in veterinary epidemiology

Advance directives and the concept of competence: are they a moral barrier to resuscitation?

Mycobacteriosis in peafowl: analysis of four cases

How to select study designs and parameters to investigate the effect of mouthrinses? Part II: Comparisons between the parameters used

Osłuchiwanie układu oddechowego przeżuwaczy

Growth factor gene delivery for Alzheimer's disease: from animal models to clinical trials

Seroprevalence, clinical, and pathological characteristics of canine leishmaniasis in a central region of Colombia

Canine hip dysplasia of selected breeds - results obtained by two Polish clinics based on radiological examination conducted in 1997-2006

Human melanoma gene therapy: from animal studies to clinical trials

Treating autoimmune diseases through restoration of antigen-specific immune tolerance