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Solcoseryl in prevention of stress-induced gastric lesions and healing of chronic ulcers

100%

Konturek S. J., Drozdowicz D., Pytko-Polonczyk J., Brzozowski T., Bielanski W.

Journal of Physiology and Pharmacology

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1991

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tom 42

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nr 1

Solcoseryl, a deproteinized extract of calf blood, protects the gastric mucosa against various topical irritants and enhances the healing of chronic gastric ulcerations but the mechanisms of these effects have been little studied. This study was designed to elucidate the active principle in Solcoseryl and to determine the role of prostaglandisn (PG) and polyamines in the antiulcer properties of this agent. Using both, the radioimmunoassay and radioreceptor assay, EGF-like material was detected in Solcoseryl preparation. Solcoseryl given s. c. prevented the formation of stress-indused gastric lesions and this was accompanied by an increase in the generation of PGE2 in the gastric mucosa. Similar effects were obtained with EGF. Pre treatment with indomethacin, to suppress mucosal generation of prostaglandins (PG), greatly augmented stress- induced gastric ulcerations and antagonized the protection exerted by both Solcoseryl and EGF. Solcoseryl, like EGF, enhanced the healing of chronic gastroduodenal ulcerations. This effect was abolished by the pretreatment with difluoro- methylomithine, an inhibitor of ornithine decarboxylas, the key enzyme in the biosynthesis of polyamines. The healing effects of Solcoseryl and EGF was also reduced by prednisolone which decreased the angiogenesis in the granulation tissue in the ulcer area. These results indicate that Solcoseryl 1. contains EGF-like material, 2. displays the protective and ulcer healing effects similar to those of EGF and involving both PG and polyamines and 3. acts via similar mechanism as does EGF.

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Gastric ulcer healing in mouse model of infection with cytotoxin expressing strain of Helicobacter pylori

80%

Brzozowski T., Konturek P. C., Karczewska E., Pajdo R., Ghiara P., Hahn E. G., Konturek S. J.

Journal of Physiology and Pharmacology. Supplement

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1997

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tom 48

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nr 1

3

Role of interleukin-4 in down-regulation of endothelin-1 during gastric ulcer healing: effect of sucralfate

80%

Slomiany B. L., Piotrowski J., Slomiany A.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 1

4

First non-conventional veterinary treatment of skin infections with blowfly larvae [Calliphoridae] in Slovakia

80%

Kocisova A., Conkova E., Pistl J., Toporcak J.

Bulletin of the Veterinary Institute in Puławy

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2003

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tom 47

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nr 2

Ograniczanie wyników

2 Journal of Physiology and Pharmacology

1 Bulletin of the Veterinary Institute in Puławy

1 Journal of Physiology and Pharmacology. Supplement

2 Brzozowski T.

2 Konturek S. J.

1 Bielanski W.

1 Conkova E.

1 Drozdowicz D.

1 Ghiara P.

1 Hahn E. G.

1 Karczewska E.

1 Kocisova A.

1 Konturek P. C.

1 Pajdo R.

1 Piotrowski J.

1 Pistl J.

1 Pytko-Polonczyk J.

1 Slomiany A.

1 Slomiany B. L.

1 Toporcak J.

1 2003

1 2000

1 1997

1 1991

Solcoseryl in prevention of stress-induced gastric lesions and healing of chronic ulcers

Gastric ulcer healing in mouse model of infection with cytotoxin expressing strain of Helicobacter pylori

Role of interleukin-4 in down-regulation of endothelin-1 during gastric ulcer healing: effect of sucralfate

First non-conventional veterinary treatment of skin infections with blowfly larvae [Calliphoridae] in Slovakia