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Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats

100%

Yalcin M., Savci V., Jochem J.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

133-137

Histamine, acting centrally as a neurotransmitter, evokes a reversal of haemorrhagic shock in rats due to the activation of the sympathetic and the renin-angiotensin systems as well as the release of arginine vasopressin and proopiomelanocortin-derived peptides. In the present study, we demonstrate influences of cholinergic receptor antagonists on the central histamine-induced resuscitating action. Experiments were carried out in male anaesthetised Wistar rats subjected to a haemorrhagic hypotension of 20-25 mmHg, resulting in the death of all control animals within 30 min. Histamine (100 nmol) administered intracerebroventricularly (icv) at 5 min of critical hypotension produced a long-lasting pressor effect with increases in heart rate and peripheral blood flows, and a 100% survival at 2 h. Mean arterial pressure and blood flow changes were almost completely blocked by nicotinic receptor antagonist mecamylamine (246.3 nmol; icv) and partially inhibited by muscarinic receptor blocker atropine sulphate (14.8 nmol; icv). Cholinergic receptor antagonists given alone in the control saline-treated groups did not affect cardiovascular parameters in the post-bleeding period. In conclusion, there are interactions between the histaminergic and cholinergic systems, with an involvement of both nicotinic and muscarinic receptors, in the central cardiovascular regulation in haemorrhagic hypotension in rats.

2

Cholinergic innervation and calretinin-immunoreactive neurones in the hippocampus during postnatal development of the rat brain

84%

Ludkiewicz B., Wojcik S., Spodnik E., Domaradzka-Pytel B., Morys J.

Folia Morphologica

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2002

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tom 61

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nr 1

7-14

Immunohistochemical study of the cholinergic innervation of the hippocampal calretinin-containing cells was conducted on 28 rat brains of postnatal ages: P0, P4, P7, P14, P21, P30 and P60. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and calretinin were analysed using confocal laser-scanning microscope. Obtained data demonstrate that during development as well as in adult species calretinin-containing neurones in the rat hippocampus form sparse synaptic contact with VAChT-ir terminals. It seems probable that cholinergic innervation is not crucial for the functioning of CR-ir cells — probably they remain under the greater influence of a system other than the cholinergic system.

3

Social interaction and acoustic communication in adult mice: markers for healthy and pathological behaviors

84%

Granon S., Chauveau F., Nosjean A., Faure A.

Acta Neurobiologiae Experimentalis

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2019

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tom 79

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nr Suppl.1

Adapted social behavior allows both individual and collective well‑being. At the individual level, it is a hallmark of health. Indeed, virtually all mental health disorders are associated with social deficits. We are interested in understanding the behavioral, neural, and neurochemical bases of social cognition and communication using mouse models. Here, we will review our recent data showing the crucial role of the prefrontal cortex in the organisation of adapted social interaction, the interplay between the cholinergic and the noradrenergic systems for the balance between affiliative interaction, dominance, and control of aggressiveness, and we will discuss the putative role of ultrasonic communication in social interactions in adult animals. We will see the role played by the environment of life and by the context in which interactions take place in healthy individuals and in pathological situations. Together, the data presented will offer a novel focus on the social brain – and social life – of rodents and provide some practical recommendations for future experiments.

4

Association between polymorphisms in CHRNA3 and PHACTR2 gene and environment and NSCLC risk in Chinese population

84%

Lou G., Zhang Y., Bao W., Deng D.

Acta Biochimica Polonica

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2014

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tom 61

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nr 4

5

Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain

84%

Ludkiewicz B., Wojcik S., Spodnik E., Domaradzka-Pytel B., Klejbor I., Morys J.

Folia Morphologica

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2002

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tom 61

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nr 2

89-96

Immunohistochemical study of the cholinergic innervation of the parvalbuminand calbindin-containing cells in the hippocampus was conducted on 30 rat brains of various postnatal ages: P0, P4, P7, P14, P21, P30, P60 and P180. Sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and parvalbumin (PV) or calbindin (CB) were analysed using confocal laser-scanning microscope. Obtained data demonstrate that the pattern of cholinergic innervation of calbindin- and parvalbumin-immunoreactive hippocampal neurones shows some differences. During development as well as in the adult species cholinergic terminals preferentially innervate CB-containing neurones, while cholinergic terminals on PV-containing cells were observed rarely. Cholinergic endings on the CB-ir neurones are localised both on their somata and dendrites, whereas on PV-ir cells they form synaptic contact predominantly with processes. In spite of the unquestionable cholinergic influence particularly on CB-ir cells, the number of cholinergic endings suggests that this input seems not to be crucial for the activity of the studied cell populations.

6

Scopolamine impairs object exploration but not habituation in rats

84%

Lukaszewska I.

Acta Neurobiologiae Experimentalis

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1993

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tom 53

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nr 1

7

Cholinergic endings on various neurones containing calcium binding proteins and glutamic acid decarboxylase in the hippocampus of the rat

84%

Ludkiewicz B., Wojcik S., Spodnik E., Domaradzka-Pytel B., Morys J.

Folia Morphologica

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2000

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tom 59

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nr 4

Immunohistochemical study of the cholinergic innervation of the hippocampal cells containing glutamic acid decarboxylase (GAD) and calcium binding proteins: parvalbumin (PV), calbindin D28k (CB) and calretinin (CR) was conducted on 5 adult rat brains. Analysis of sections with double immunostaining for vesicular acetylcholine transporter (VAChT; the marker of cholinergic cells, fibres and terminals) and respectively either GAD or PV, CB, CR, using confocal laser-scanning microscope shows that the intensive cholinergic innervations receive GAD, PV and CB-positive hippocampal cells. Cholinergic afferentations of the CR-positive neurones are considerably fewer.

8

Cholinergic modulation of synaptic transmission in horizontal connections of rat motor cortex

67%

Hess G., Krawczyk R.

Acta Neurobiologiae Experimentalis

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1996

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tom 56

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nr 4

9

Perseverative errors and reversal of a visual discrimination following basal forebrain lesions in the rat

67%

Wilson W. J., Cook J. A.

Acta Neurobiologiae Experimentalis

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1995

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tom 55

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nr 4

10

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The neuromodulation aspects of ischaemic myocardium: the importance of cholinergic system

67%

Gajewski M., Moutiris J. A., Maslinski S., Ryzewski J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 2

11

Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones

67%

Bugajski J., Gadek-Michalska A., Bugajski A. J.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 4

The review presents our results on the regulatory role of prostaglandins (PG) and nitric oxide (NO) in the activation of hypothalamic-pituitary-adrenal (HPA) axis by cholinergic, adrenergic and histaminergic systems and by neurohormones: corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) under basal conditions. The synthesis of endogenous PG or NO was inhibited by non-selective and selective cyclooxygenase (COX) antagonists and nitric oxide synthase (NOS) blockers given 15 min before the respective receptor agonist and HPA axis activity was assessed 1 h later by measuring plasma ACTH and serum corticosterone levels. The muscarinic agent - carbachol-induced HPA response was considerably supressed by piroxicam, a predominantly constitutive cyclooxygenase (COX-1) inhibitor and significantly diminished by indomethacin, a non-selective COX blocker, but was unaffected by compound NS-398, an inducible cyclooxygenase (COX-2) antagonist. A non-selective NOS antagonist L-NAME and neuronal NOS blocker L-NNA significantly intensified the carbachol-induced corticosterone secretion. The nicotine-induced increase in ACTH and corticosterone response was significantly supressed by piroxicam, and diminished by indomethacin, but was significantly augmented by L-NAME and L-NNA. The inhibition of PG synthesis by indomethacin totally abolished or reversed the increase of nicotine-induced hormone responses to both NOS blockers. The i.c.v. phenylephrine, an alpha1-adrenergic receptor agonist - evoked HPA response was significantly impaired by piroxicam and compound NS-398 and more potently reduced by L-NAME. The i.c.v. clonidine, an alpha2-adrenergic agonist - elicited HPA response was also considerably decreased by piroxicam, compound NS-398 and L-NAME. By contrast, the stimulatory effect of i.c.v. isoprenaline, a non-selective ß-adrenergic agonist, was not altered by either COX or NOS inhibitors. The i.c.v. histamine- and HTMT, a histamine H1-agonist-induced ACTH and corticosterone response were significantly diminished by piroxicam and indomethacin, respectively. Compound NS-398, did not markedly alter the HPA response to HTMT or amthamine, a histamine H2 receptor agonist. Inhibition of endogenous NO synthesis by a neuronal NOS inhibitor 7-nitroindazole markedly enhanced the histamine-induced hormone secretion, abolished the HTMT-induced response and did not substantially alter the amthamine-evoked ACTH and corticosterone secretion. COX blockers did not significantly affect the CRH-induced HPA response and the inhibition of NO synthesis by L-NNA markedly intensified ACTH response. The vasopressin-stimulated increase in HPA response, was considerably reduced by the inhibition of PG synthesis by both COX antagonists while inhibition of NO synthesis by NOS blockers greatly enhanced this response. The involvement of PG and NO in the neurohormonal regulation of HPA activity depends mainly on greatly complex and tightly regulated mechanisms at the level of second messengers IP3 and adenylyl cyclase systems.

12

Behaviour - related effects of physostigmine on the rat visual evoked potential

67%

Bringmann A.

Acta Neurobiologiae Experimentalis

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1994

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tom 54

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nr 4

Ograniczanie wyników

Involvement of the cholinergic system in the central histamine-induced reversal of critical haemorrhagic hypotension in rats

Cholinergic innervation and calretinin-immunoreactive neurones in the hippocampus during postnatal development of the rat brain

Social interaction and acoustic communication in adult mice: markers for healthy and pathological behaviors

Association between polymorphisms in CHRNA3 and PHACTR2 gene and environment and NSCLC risk in Chinese population

Cholinergic innervation of parvalbumin- and calbindin-containing neurones in the hippocampus during postnatal development of the rat brain

Scopolamine impairs object exploration but not habituation in rats

Cholinergic endings on various neurones containing calcium binding proteins and glutamic acid decarboxylase in the hippocampus of the rat

Cholinergic modulation of synaptic transmission in horizontal connections of rat motor cortex

Perseverative errors and reversal of a visual discrimination following basal forebrain lesions in the rat

The neuromodulation aspects of ischaemic myocardium: the importance of cholinergic system

Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones

Behaviour - related effects of physostigmine on the rat visual evoked potential