Wyniki wyszukiwania

1

Correlation between hyperdiploidy 51plus of acute lymphoblastic leukemia and DNA ploidy

100%

Brycz-Witkowska J., Sikorska-Fic B., Stanczak H., Chmarzynska-Mroz E., Rybczynska J., Wasiutynski A., Rokicka-Milewska R., Wasik M.

Folia Histochemica et Cytobiologica. Supplement

|

2001

|

tom 39

|

nr 1

2

Food habits in childhood - results from a Swedish multicentre study 1980-1981

86%

Hagman U.

Żywienie Człowieka i Metabolizm

|

1988

|

tom 15

|

nr 4

Omówiono sposób żywienia oraz rozpowszechnienie schorzeń związanych z wadliwym żywieniem u dzieci szwedzkich w latach 1929—31 i 1967—68. Opisano wyniki przeglądu stanu odżywienia dzieci przeprowadzonego w 1980—81 roku przez Szwedzki Narodowy Nadzór Żywieniowy oraz Departament Pediatrii. Dokonano analizy wzorców spożywanych posiłków oraz spożycia składników odżywczych. Omówiono ryzyko chorób związanych z wadliwym żywieniem dzieci szwedzkich.

3

In vitro activity of axazaphosphorines in childhood acute leukemia: preliminary report

86%

Styczynski J., Wysocki M., Debski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 1

Glufosfamide (β-D-glucosyHfosfamide mustard) is a new agent for cancer chemotherapy. Its pharmacology is similar to commonly used oxazaphosphorines, but it does not require activation by hepatic cytochrome P-450 and preclinically demonstrates lower nephrotoxicity and myelosuppression than ifosfamide. The aim of the study was a comparison of the drug resistance profiles of glufosfamide and other oxazaphosphorines in childhood acute leukemias. Leukemic cells, taken from children with ALL on diagnosis (n = 41), ALL on relapse (n = 12) and AML on diagnosis (n = 13) were analyzed by means of the MTT assay. The following drugs were tested: glufosfamide (GLU), 4-HOO-ifosfamide (IFO), 4-HOO-cyclophosphamide (CYC) and mafosfamide cyclohexylamine salt (MAF). In the group of initial ALL samples median cytotoxicity values for GLU, IFO, CYC and MAF were 15.5, 33.8, 15.7 and 7.8,«M, respectively. In comparison with initial ALL samples, the relative resistance for GLU and IFO in relapsed ALL samples was 1.9 (p = 0.049) and 1.3 (ns), and in initial AML samples 31 (p < 0.001) and 5 (p = 0.001), respectively. All oxazaphosphorines presented highly significant cross-resistance. Glufosfamide presented high activity against lymphoblasts both on diagnosis and on relapse.

4

Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report

86%

Styczynski J., Wysocki M., Debski R., Balwierz W., Rokicka-Milewska R., Matysiak M., Balcerska A., Kowalczyk J., Wachowiak J., Sonta-Jakimczyk D., Chybicka A.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 1

In vitro antileukemic activity of five glucocorticoids and their cross-resistance pattern in childhood acute lymphoblastic and non-lymphoblastic leukemia were determined by means of the MTT assay in 25 leukemia cell samples of childhood acute leukemias. The equivalent antileukemic concentrations of the drugs tested were: 34 uM hydrocortisone (HC), 8 uM prednisolone (PRE), 1.5 uM methylprednisolone (MPR), 0.44 uM dexamethasone (DX) and 0.22 Mbetamethasone (BET). In comparison with initial ALL cell samples, the relapsed ALL group was more resistant to PRE (38-fold, p = 0.044), DX (> 34-fold, p = 0.04), MPR (38-fold), BET (45-fold) and HC (33-fold). TheAMLcell samples were even more resistant to: PRE (>85-fold, p=0.001), DX (> 34-fold, p = 0.004),MPR(> 69-fold, p = 0.036), BET (> 69-fold, p = 0.038) and HC (54-fold, p = 0.059) when compared with ALL on initial diagnosis. A significant cross-resistance among all the glucocorticoids used was found. Only in some individual cases the cross-resistance was less pronounced.

5

Pituitary microsomal autoantibodies in patients with childhood-onset combined pituitary hormone deficiency: an antigen identification attempt

72%

Ziemnicka K., Gut P., Golab M., Dworacki G., Wrotkowska E., Stajgis M., Katulska K., Rabska-Pietrzak B., Obara-Moszynska M., Niedziela M., Budny B., Kaluzna M., Wasko R., Ruchala M.

Archivum Immunologiae et Therapiae Experimentalis

|

2016

|

tom 64

|

nr 6

6

Allergen-specific T cells in IgE-mediated food allergy

72%

Saidova A., Hershkop A. M., Ponce M., Eiwegger T.

Archivum Immunologiae et Therapiae Experimentalis

|

2018

|

tom 66

|

nr 3

7

Type 1 diabetes: prospective cohort studies for identification of the environmental trigger

72%

Ronningen K. S.

Archivum Immunologiae et Therapiae Experimentalis

|

2013

|

tom 61

|

nr 6

8

New method for quantitative analysis of GD2 ganglioside in plasma of neuroblastoma patients

72%

Czaplicki D., Horwacik I., Kowalczyk A., Wieczorek A., Bolek-Marzec K., Balwierz W., Kozik A., Rokita H.

Acta Biochimica Polonica

|

2009

|

tom 56

|

nr 3

423-431

Neuroblastoma, the most common extracranial solid tumour of childhood, is a malignancy of unknown origin and non-specific symptoms. One of the markers of the disease is GD2 ganglioside (disialoganglioside), which is abundantly expressed on the surface of neuroblastoma cells. Gangliosides are known to be shed by tumour cells and this phenomenon can be significant in cancer progression as they inhibit a number of immune responses both in vitro and in vivo. In search for novel markers useful in monitoring and prognosis of neuroblastoma, we developed and validated a new quantitative method of GD2 ganglioside analysis in human blood plasma. We evaluated the level of gangliosides in blood serum of 34 neuroblastoma patients using high-performance liquid chromatography. The technique was used to detect fluorescently labelled oligosaccharides derived from serum glycosphingolipids by enzymatic digestion with ceramide glycanase. The developed method allowed determination of GD2 concentrations at the picomole level and required only 40 μl of plasma, which should be particularly useful when the quantity of clinical material is limiting. Moreover, this method can be applied to study concentration of other gangliosides, as shown for GD3 ganglioside. Analysis of plasma samples from the 34 neuroblastoma patients did not reveal any correlations between the concentration of GD2 ganglioside and clinical parameters, including the results of therapy; it showed, however, that the concentration of GD2 ganglioside in the plasma of neuroblastoma patients decreased substantially in the course of treatment.

9

Physical activity, obesity and health programs in selected European countries

72%

Bronikowski M., Gonzalez-Gross M., Kleiner K., Knisel E., Martinkova I., Stache A., Kantanista A., Lopez D. C., Konlechner A.

Studies in Physical Culture and Tourism

|

2008

|

tom 15

|

nr 1

10

T cell depleted haploidentical bone marrow transplantation for the treatment of children with severe combined immunodeficiency

72%

Smogorzewska E. M., Brooks J., Annett G., Kapoor N., Crooks G. M., Kohn D. B., Parkman R., Weinberg K. I.

Archivum Immunologiae et Therapiae Experimentalis

|

2000

|

tom 48

|

nr 2

11

Expression of naive-memory [CD45RA-CD45RO] markers by peripheral blood CD4plus and CD8plus T cells in children with asthma

72%

Machura E., Mazur B., Pieniazek W., Karczewska K.

Archivum Immunologiae et Therapiae Experimentalis

|

2008

|

tom 56

|

nr 1

12

Combination therapy in childhood leukemia, in vitro studies of thiopurines and inhibitors of purine metabolisms on apoptosis

72%

Trueworthy R., De Abreu R., Vogels-Mentink T., Lambooy L. M.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 3

13

TEL-JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine

72%

Gloc E., Warszawski M., Mlynarski W., Stolarska M., Hoser G., Skorski T., Blasiak J.

Acta Biochimica Polonica

|

2002

|

tom 49

|

nr 1

The TEL/JAK2 chromosomal translocation (t(9;12)(p24;p13)) is associated with T cell childhood acute lymphoblastic leukemia. The TEL/JAK2 fusion protein contains the JAK2 catalytic domain and the TEL-specific oligomerization domain. TEL-mediated oligomerization of the TEL/JAK2 proteins results in the constitutive activation of the tyrosine kinase activity. Leukemia cells expressing TEL/JAK2 tyrosine kinase become resistant to anti-neoplastic drugs. Amifostine is a pro-drug which can selectively protect normal tissues against the toxicity of anticancer drugs and radiation. We investigated the effects of amifostine on idarubicin-induced DNA damage and repair in murine pro-B lymphoid BaF3 cells and BaF3-TEL/JAK2-transformed cells using alkaline single cell gel electrophoresis (comet assay). Idarubicin induced DNA damage in both cell types but amifostine reduced its extent in control non-transformed BaF3 cells and enhanced it in TEL/JAK2-transformed cells. The transformed cells did not show measurable DNA repair after exposure to amifostine and idarubicin, but cells treated only with idarubicin were able to recover within a 60-min incubation. Because TEL/JAK2-transformed cells can be considered as model cells for certain human leukemias and lymphomas we anticipate an enhancement of idarubicin cytotoxicity by amifostine in these diseases. Moreover, TEL/JAK2 tyrosine kinase might be involved in cellular response to DNA damage. Amifostine could promote apoptosis or lower the threshold for apoptosis induction dependent on TEL/JAK2 activation.

14

Wheezing and asthma may be enhanced by broad spectrum antibiotics used in early childhood. Concept and results of a pharmacoepidemiology study

58%

Jedrychowski W., Perera F., Maugeri U., Mroz E., Flak E., Perzanowski M., Majewska R.

Journal of Physiology and Pharmacology

|

2011

|

tom 62

|

nr 2

One of the mechanisms supposed to explain the increasing prevalence of asthma, among children in particular, is the use of antibiotics because they may modify natural microbial exposure and development of the immune system in early childhood. The aim of this study is to investigate the association between the use of various classes of antibiotics (penicillin, cephalosporin and macrolide derivatives) in early childhood and the medical diagnosis of asthma or wheezing reported by mothers over the follow-up after adjustment for potential confounders and respiratory infections. In a population-based sample of 5-year-olds, a part of the ongoing birth cohort study, the standardized interviews on health outcomes, potential confounders (child’s gender, maternal atopy, parity, prenatal and postnatal environmental tobacco smoke) and the use of antibiotics were gathered from mothers of 310 children. While the overall use of antibiotics during the early childhood was insignificantly associated with asthma (adjusted OR = 1.65, 95%CI: 0.93 – 2.93), the risk estimates were significant both for macrolide antibiotics (adjusted OR=2.14, 95%CI: 1.16–3.95) and cephalosporins (OR=1.98, 95%CI: 1.14–3.37). The significant excess in IRR (incident risk ratio) of wheezing episodes was related only to the use of macrolide antibiotics (adjusted IRR=1.91, 95%CI: 1.12–3.27). The use of other classes of antibiotics was found not to be associated with the medical diagnosis of asthma or wheezing episodes recorded in the study period. Conclusion: as early childhood use of broad spectrum antibiotics is associated with an increased risk of developing asthma in 5-year-olds, it may be hypothesized that the antibiotic- related suppression of allergic inflammatory responses in the course of treatment may later lead to greater than before atopic immune response in Th2 children or an impairment of Th1 immune responses in early childhood.

15

Features of impaired seminiferous tubule differentiation are associated with germ cell neoplasia in adult men surgically treated in childhood because of cryptorchidism

58%

Guminska A., Slowikowska-Hilczer J., Kuzanski W., Sosnowski M., Oszukowska E., Marchlewska K., Walczak-Jedrzejowska R., Niedzielski J., Kula K.

Folia Histochemica et Cytobiologica. Supplement

|

2007

|

tom 45

|

nr 1

163-168

16

Association of oxidative stress and GST-T1 gene with childhood bronchial asthma

58%

Babusikova E., Jesenak M., Kirschnerova R., Banovcin P., Dobrota D.

Journal of Physiology and Pharmacology. Supplement

|

2009

|

tom 60

|

nr 5

17

Cough reflex sensitivity in various phenotypes of childhood asthma

58%

Jesenak M., Babusikova E., Petrikova M., Turcan T., Rennerova Z., Michnova Z., Havlicekova Z., Villa M. P., Banovcin P.

Journal of Physiology and Pharmacology. Supplement

|

2009

|

tom 60

|

nr 5

18

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

58%

Varechova S., Plevkova J., Hanacek J., Tatar M.

Journal of Physiology and Pharmacology. Supplement

|

2008

|

tom 59

|

nr 6

719-726

19

Detection of substance P and its mRNA in human blast cells in childhood lymphoblastic leukaemia using immunocytochemistry and in situ hybridisation

58%

Nowicki M., Miskowiak B., Ostalska-Nowicka D.

Folia Histochemica et Cytobiologica

|

2003

|

tom 41

|

nr 1

20

HPLC-analysis of low amounts of methotrexate and its polyglutamates in red blood cell lysates after low-dose methotrexate maintenance treatment for childhood acute lymphoblastic leukaemia

58%

Ter Riet P. G. J. H., Brouwer C., De Abreu R. A., Bokkerink J. P. M., Trijbels F. J. M.

Cellular and Molecular Biology Letters

|

1999

|

tom 04

|

nr 3

Ograniczanie wyników

Correlation between hyperdiploidy 51plus of acute lymphoblastic leukemia and DNA ploidy

Food habits in childhood - results from a Swedish multicentre study 1980-1981

In vitro activity of axazaphosphorines in childhood acute leukemia: preliminary report

Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: Preliminary report

Pituitary microsomal autoantibodies in patients with childhood-onset combined pituitary hormone deficiency: an antigen identification attempt

Allergen-specific T cells in IgE-mediated food allergy

Type 1 diabetes: prospective cohort studies for identification of the environmental trigger

New method for quantitative analysis of GD2 ganglioside in plasma of neuroblastoma patients

Physical activity, obesity and health programs in selected European countries

T cell depleted haploidentical bone marrow transplantation for the treatment of children with severe combined immunodeficiency

Expression of naive-memory [CD45RA-CD45RO] markers by peripheral blood CD4plus and CD8plus T cells in children with asthma

Combination therapy in childhood leukemia, in vitro studies of thiopurines and inhibitors of purine metabolisms on apoptosis

TEL-JAK2 tyrosine kinase inhibits DNA repair in the presence of amifostine

Wheezing and asthma may be enhanced by broad spectrum antibiotics used in early childhood. Concept and results of a pharmacoepidemiology study

Features of impaired seminiferous tubule differentiation are associated with germ cell neoplasia in adult men surgically treated in childhood because of cryptorchidism

Association of oxidative stress and GST-T1 gene with childhood bronchial asthma

Cough reflex sensitivity in various phenotypes of childhood asthma

Role of gender and pubertal stage on cough sensitivity in childhood and adolescence

Detection of substance P and its mRNA in human blast cells in childhood lymphoblastic leukaemia using immunocytochemistry and in situ hybridisation

HPLC-analysis of low amounts of methotrexate and its polyglutamates in red blood cell lysates after low-dose methotrexate maintenance treatment for childhood acute lymphoblastic leukaemia