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The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat

100%

Wiemann M., Piechatzek L., Gopelt K., Kiwull-Schone H., Kiwull P., Bingmann D.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 1

The effect of AVE1599, an inhibitor of the sodium/proton exchanger type 3 (NHE3), on phrenic nerve (PN) activity was investigated using the working heart brainstem preparation (WHBP). Hypercapnia (pH: -0.1) applied for 10 min reversibly increased PN frequency (f) by 66.0 ± 19.5% and decreased burst duration by 23.3 ± 3% (mean ± SE, n = 21). Similarly, AVE1599 (0.3µM) increased f after 10 and 30 min by 75.1 ± 13.2 and 176 ± 36.2% (n = 10), respectively, and reduced duration of PN bursts by 24.9 ± 10.8%. Hypercapnia-induced increases of f were attenuated by AVE1599. An elevated concentration of AVE1599 (0.9µM) had no significant effect on PN. As AVE1599 accumulates in brain tissue and might interfere with the less affine NHE1, we furthermore tested the NHE1-inhibitor HOE642. In fact, HOE642 (0.9µM) diminished f by 88.5 ± 9.2 and 58.6 ± 10.0% after 10 and 30 min (n = 6), respectively, but did not abolish hypercapnic responses. We conclude that AVE1599 augments central respiratory drive in the WHBP via NHE3 but not NHE1 inhibition.

2

Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy

86%

Pospisilova M., Seifrtova M., Rezacova M.

Journal of Physiology and Pharmacology

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2017

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tom 68

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nr 3

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Chemosensitivity of a chloroquine-resistant Plasmodium falciparum isolate to quinine - type compounds in vitro

86%

Nair L., Bhasin V. K.

Acta Protozoologica

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1993

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tom 32

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nr 2

4

Ratio of proliferation markers and HSP90 gene expression as a predictor of pathological complete response in breast cancer neoadjuvant chemotherapy

72%

Jarzab M., Kowal M., Bal W., Oczko-Wojciechowska M., Rembak-Szynkiewicz J., Kowalska M., Stobiecka E., Chmielik E., Tyszkiewicz T., Kaszuba M., Nowicka E., Lange B., Czarniecka A., Krajewska J., Dyla A., Dobrut M., Lange D., Jarzab B., Bobek-Billewicz B., Tarnawski R.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 4

5

Expression of anion exchanger 3 influences respiratory rate in awake and isofurane anesthetized mice

72%

Meier S., Hubner C. A., Groeben H., Peters J., Bingmann D., Wiemann M.

Journal of Physiology and Pharmacology. Supplement

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2007

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tom 58

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nr 5

6

Effect of moderate and high intensity training sessions on cardiopulmonary chemosensitivity and time-based characteristics of response in high performance rowers

72%

Tomiak T., Mishchenko V., Lusenko E., Diachenko A., Korol A.

Baltic Journal of Health and Physical Activity. The Journal of Gdansk University of Physical Education and Sport

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2014

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tom 06

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nr 3

Background: The present study was performed to clarify fatigue-induced effects of a strenuous and moderate intensity endurance training session on temporary changes of cardiopulmonary (CP) chemosensitivity and fast kinetics response. Material/Methods: Eleven high performance (national level) male rowers participated in this study [age 21.8 ±1.7 (range 18-25 years), 89.3 ±2.0 kg, 190.1 ±1.7 cm, VO2 max 67.9 ±1.1 ml·kg-1·min-1]. The studies involved three steps: 1) a study of effects related to a training session of moderate intensity, 2) effects of a high intensity session, and 3) an impact of a high intensity session on values of peak response. The high intensity session consisted of intermittent training loads made up of five sets of four repetitions of sixty-second work intervals (HR of 149-186 bt·min-1). The moderate intensity session consisted of unvarying type of exercise (HR of 138-167 bt·min-1). Measurements were made at rest before, 13-15, and 37-39 hours after the training session. In rebreathing tests ventilatory sensitivity to CO2 and HR response sensitivity to normocapnic hypoxia were measured. Fast kinetics of ventilation, oxygen uptake, CO2 production and the heart rate were measured in a 5-min standard power test (0.7 VO2 max, 5 min, transition from 25 w) and in a 6-min test (1.12 ±0.11 VO2max). Results: We found that a training session of high intensity resulted in a significant decrease in sensitivity to hypercapnia, an increase in CP sensitivity to hypoxia, a decrease in CP fast kinetics and stability of peak response 13-15 hours after the session vs. baseline. Mean power in a 6-min maximum test decreased, which was mainly determined by a decrease in mean power during the first 3 min and utilization of VO2 max for a 6-min test. Moderate intensity of a training session resulted in an increase in ventilatory sensitivity to hypercapnia whereas sensitivity CP to hypoxia and fast kinetics remained unaffected. Conclusions: These results suggest that not only CP chemosensitivity to hypoxia but also CP chemosensitivity to hypercapnia are variable in high intensity endurance training. The variability related to the effect of fatigue in the recovery phase (up to 15-15 hours) after strenuous training sessions.

7

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The shRNA-mediated silencing of VEGF-C illustrates its role in proliferation, chemosensitization, tumour colonization, and anchorage independence

72%

Tambe P., Purohit I., Suneja D., More S., Desai P., Shrivastava N.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2015

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tom 96

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nr 3

8

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

72%

Vogt U., Falkiewicz B., Bielawski K., Bosse U., Schlotter C. M.

Acta Biochimica Polonica

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2000

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tom 47

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nr 1

A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.

9

Comparative analysis of different methodological approaches to the in vitro study of tumour cells chemosensitivity

72%

Paduch R., Slotwinska M., Stachura A., Rzeski W., Zdzisinska B., Kandefer-Szerszen M.

Annales Universitatis Mariae Curie-Sklodowska. Sectio C, Biologia

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2001

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tom 56

10

C-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

58%

Falkiewicz B., Schlotter C. M., Bosse U., Bielawski K., Vogt U.

Acta Biochimica Polonica

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2000

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tom 47

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nr 1

A pilot study on relationships of selected molecular factors (c-myc oncogene average gene copy numbers (AGCN); serum CEA and CA 15.3 antigen levels; tumor cells' DNA values), to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Four drug combinations were tested. A group of 75 cases of female primary breast cancer was assessed. Numerous correlations were found among molecular factors tested but none, with the exception of tumor grading, of these reflected ex vivo chemosensitivity of tumors tested. The results suggest that the parameters tested may not be important factors related to adjuvant chemoresponsiveness of primary human breast cancer to tested drug combinations

Ograniczanie wyników

The NHE3 inhibitor AVE1599 stimulates phrenic nerve activity in the rat

Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy

Chemosensitivity of a chloroquine-resistant Plasmodium falciparum isolate to quinine - type compounds in vitro

Ratio of proliferation markers and HSP90 gene expression as a predictor of pathological complete response in breast cancer neoadjuvant chemotherapy

Expression of anion exchanger 3 influences respiratory rate in awake and isofurane anesthetized mice

Effect of moderate and high intensity training sessions on cardiopulmonary chemosensitivity and time-based characteristics of response in high performance rowers

The shRNA-mediated silencing of VEGF-C illustrates its role in proliferation, chemosensitization, tumour colonization, and anchorage independence

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay

Comparative analysis of different methodological approaches to the in vitro study of tumour cells chemosensitivity

C-myc oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer