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1

Rapid proliferation of activated lymph node CD4plus T cells is achieved by greatly curtailing the duration of gap phases in cell cycle progression

100%
Mishima T., Toda S., Ando Y., Matsunaga T., Inobe M.
Cellular and Molecular Biology Letters
|
2014
|
tom 19
|
nr 4
Peripheral T cells are in G0 phase and do not proliferate. When they encounter an antigen, they enter the cell cycle and proliferate in order to initiate an active immune response. Here, we have determined the first two cell cycle times of a leading population of CD4+ T cells stimulated by PMA plus ionomycin in vitro. The first cell cycle began around 10 h after stimulation and took approximately 16 h. Surprisingly, the second cell cycle was extremely rapid and required only 6 h. T cells might have a unique regulatory mechanism to compensate for the shortage of the gap phases in cell cycle progression. This unique feature might be a basis for a quick immune response against pathogens, as it maximizes the rate of proliferation.
2

Epac1 is involved in cell cycle progression in lung cancer through PKC and Cx43 regulation

100%
Sun Q., Wang D., Ai G., Tian L., Zhao L., Chen R., Wang K., Guo D., Yao Y., Liu W., Kong X., Chen X., Zhang Y.
Folia Histochemica et Cytobiologica
|
2018
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tom 56
|
nr 1
3
Content available remote

Role of P53 tumor suppressor in ageing: regulation of transient cell cycle arrest and terminal senescence

100%
Wegierska-Gadek J., Wojciechowski J., Ranftler C., Schmid G.
Journal of Physiology and Pharmacology
|
2005
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tom 56
|
nr 1
In this study we investigated the function of p53 as a regulator of cell cycle progression in cycling and senescent cells. Using the conditional temperature-sensitive (ts) mutant we could prevent the detrimental effect of constitutive expression of high levels of wt p53 protein. High levels of wt p53 inhibited cell proliferation by blocking the cells to progress from G1 to S phase of the cell cycle. Flow cytometric analysis revelaed a maintenance of G1 cell population for a longer time depending on the prolonged expression of wt p53 protein. The p53 mediated inhibition of cell proliferation and of the cycle was reversible. However, a spontaneous increase of wt p53 occurring in ageing normal human MRC-5 fibroblasts was associated with irreversible reduction of proliferative potential. The accumulation of G1 cells was detected by flow cytometry. By the measurement of DNA content it is not possible to discriminate between cells arrested in G1 and Go phase, therefore, the expression of G1 markers was determined. Analysis of the expression of distinct cell cycle regulators revealed that quiescent MRC-5 cells were in Go phase. Our results indicate that cell cycle arrest occurring in senescent cells is associated with the Go transition.
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Cyclic AMP deficiency stimulates a stress condition in tobacco BY-2 cells

84%
Sgobba A., Sabetta W., Blanco E., Paradiso A., Viggiano L., De Pinto M.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
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tom 94
|
nr 2
5

Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway

84%
Luo Y.-R., Zhou S.-T., Yang L., Liu Y.-P., Jiang S.-Y., Dawuli Y., Hou Y.-X., Zhou T.-X., Yang Z.-B.
Journal of Veterinary Research
|
2020
|
tom 64
|
nr 1
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

In silico modeling of an interaction network of genes involved in the cell cycle progression during root morphogenesis in mono- and dicotyledonous plants

84%
Slota M., Maluszynski M., Szarejko I.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
|
2013
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tom 94
|
nr 3
7

Cannabinoid receptor activation inhibits cell cycle progression by modulating 14-3-3beta

84%
Jung H.-W., Park I., Ghil S.
Cellular and Molecular Biology Letters
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2014
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tom 19
|
nr 3
Cannabinoids display various pharmacological activities, including tumor regression, anti-inflammatory and neuroprotective effects. To investigate the molecular mechanisms underlying the pharmacological effects of cannabinoids, we used a yeast two-hybrid system to screen a mouse brain cDNA library for proteins interacting with type 1 cannabinoid receptor (CB1R). Using the intracellular loop 3 of CB1R as bait, we identified 14-3-3β as an interacting partner of CB1R and confirmed their interaction using affinity-binding assays. 14-3-3β has been reported to induce a cell cycle delay at the G2/M phase. We tested the effects of cannabinoids on cell cycle progression in HeLa cells synchronized using a double-thymidine block-and-release protocol and found an increase in the population of G2/M phase cells. We further found that CB1R activation augmented the interaction of 14-3-3β with Wee1 and Cdc25B, and promoted phosphorylation of Cdc2 at Tyr-15. These results suggest that cannabinoids induce cell cycle delay at the G2/M phase by activating 14-3-3β.
8

The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research

67%
Ostrowska H.
Cellular and Molecular Biology Letters
|
2008
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tom 13
|
nr 3
353-365
The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-κB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the pathogenesis of many human diseases, so both the ubiquitin-conjugating system and the 20S proteasome are important targets for drug discovery. This article presents a few of the most important examples of the small molecule inhibitors and modulators targeting the ubiquitin-proteasome system, their mode of action, and their potential therapeutic relevance in the treatment of cancer and inflammatory-related diseases.
9

Human T cell leukemia virus type 1: the role of Tax in leukemogenesis

67%
Pise-Masison C. A., Jeong S. J., Brady J. N.
Archivum Immunologiae et Therapiae Experimentalis
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2005
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tom 53
|
nr 4
10

Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine

67%
Wesierska-Gadek J., Schreiner T., Maurer M., Waringer A., Ranftler C.
Cellular and Molecular Biology Letters
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2007
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tom 12
|
nr 2
Estrogens play an important role in the growth and terminal differentiation of the mammary gland. Prolonged exposure to estrogens seems to predispose women to breast cancer. It recently became evident that not only the intrinsic hormonal status but also external factors such as the occurrence of pharmaceuticals and chemicals with hormone activity in the environment may put women at greater risk of developing breast cancer. We focused on the interference of endocrine disruptors in breast cancer therapy. We observed that phenol red added to the culture medium strongly promoted the cell proliferation and cell cycle progression of human cells expressing the estrogen receptor, and affected their susceptibility to chemotherapy.
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