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  1. 18 Folia Histochemica et Cytobiologica

  2. 6 Journal of Physiology and Pharmacology

  3. 5 Cellular and Molecular Biology Letters

  4. 2 Archivum Immunologiae et Therapiae Experimentalis

  5. 2 Bulletin of the Veterinary Institute in Puławy

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  1. 2 Dragojew S.

  2. 2 Jozwiak Z.

  3. 2 Pedrycz A.

  4. 2 Piotrowski J.

  5. 2 Slomiany A.

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  1. 2 2021

  2. 1 2020

  3. 3 2019

  4. 3 2018

  5. 1 2017

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1

Immunohistochemical evaluation of caspase 3 expression in rats' hepatocytes after L-arginine therapy

100%
Pedrycz A., Kot K., Olesinski I.
Bulletin of the Veterinary Institute in Puławy
|
2010
|
tom 54
|
nr 1
101-103
The apoptotical effect of nitric oxide on effector apoptotical caspase 3 in rats' hepatocytes was examined. The experiment was performed on 16 white Wistar female rats divided into two equal groups. The rats from the experimental group received orally L-arginine in a dose of 40 mg/kg b.w. every other day for 2 weeks. The rats from the control group received orally 2 ml of distilled water in the same manner as the experimental group. All the rats were decapitated after 3 weeks of the experiment. After decapitation, specimens from the liver were collected, fixed in 10% formalin, and then embedded in paraffin blocks. Protein caspase 3 on slides was detected using the standard three-step immunohistochemical method. The quantitative evaluation of caspase 3 expression showed that the area occupied by positive caspase 3 reaction in the liver of the experimental group (128.11 µm²±96.54) was comparable to that in the control group (212.18 µm² ±1 16.59) (P=0.25). The dose of L-arginine used was similar to that applied in pregnant women treated for gestosis. The study shows that L-arginine as a donor of exogenous nitric oxide has no an apoptotic effect on rats' hepatocytes.
2
Content available remote

Effects of estrone on quisqualate-induced toxicity in primary cultures of rat cortical neurons

100%
Kajta M., Marszal M., Kubera M., Lason W.
Journal of Physiology and Pharmacology
|
2005
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tom 56
|
nr 2
Estrogens exert protective effects against neurotoxic changes induced by over-activation of ionotrophic glutamate receptors, whereas little is known about their interaction with changes mediated by metabotropic glutamate receptors. We evaluated effects of estrone on quisqualate (QA)-induced toxicity in neuronal cell cultures on 7 and 12 day in vitro (DIV). Twenty four hour exposure to QA (150 µM and 300 µM) significantly decreased cell survival in 7 day old cultures, but the 12 day old cultures were more resistant to its toxicity. DNQX (10 µM), an AMPA/kainate receptor antagonist, partly attenuated the toxic effects of QA, whereas LY 367 385 (100 µM), a selective mGluR1alpha antagonist, completely reversed the above effect. QA did not activate, but suppressed spontaneous caspase-3-like activity. Estrone (100 nM and 500 nM) attenuated QA-mediated neurotoxic effects independently of estrogen receptors, as indicated with ICI 182, 780 and without affecting the caspase-3-like activity. At early stage of development in vitro (7 DIV) toxic effects of QA were more profound and mediated mainly by metabotropic glutamate receptors of group I, whereas later (12 DIV) they were mediated mostly by ionotropic AMPA/kainate receptors. The toxic effects of QA were partly accompanied by anti-apoptotic action against spontaneous caspase-3-like activity, possibly due to modulation of neuronal plasticity.
3
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Only live Helicobacter pylori is capable of caspase-3 dependent apoptosis induction in gastric mucosa epithelial cells

84%
Pierzchalski P., Pytko-Polonczyk J., Jaworek J., Konturek S. J., Gonciarz M.
Journal of Physiology and Pharmacology
|
2009
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tom 60
|
nr 4
119-128
Physiological process of cell death, apoptosis, plays a beneficial role in organism survival, but in some pathologies, like gastric Helicobacter pylori (Hp) infection, this process may turn against the host organism causing tissue damage. Knowledge of the mechanisms controlling apoptosis may have potential significance in treatment of these pathologic states. Therefore, we sought to determine whether apoptosis induced in the gastric epithelial cells exposed to live Hp involves the alteration in heat shock protein 70 (HSP70) expression and activation of caspase-3 in peroxisome proliferator-activated receptors (PPARg dependent manner). Experiments were performed with KATO III, gastric epithelial cells, exposed to CagA and Vac A positive live Hp , water Hp extracts or Hp culture supernatant over different time periods. Total cellular RNA and proteins were isolated for PCR, western-blot and EMSA studies. Genomic DNA was isolated to analyze apoptosis status. We propose new model of Hp induced HSP70 dependent, caspase-3 executed apoptosis in human gastric epithelium. KATO III cells exposed to Hp , showed an increase in caspase-3 activity accompanied and preceeded by activation of nuclear translocation of PPAR peaking at 48 h of culture. Moreover, heat shock factor 1 (HSF-1) bound up with phosphorylated STAT-3 was unable to activate HSP70 protein synthesis in KATO III exposed to Hp . Lack of protective effect of HSP70, activation of caspase-3 - dependent apoptosis pathway caused by Hp and alteration of the bax/bcl-2 cellular equilibrium led to gastric epithelial cell death. The observed phenomenon might be helpful in understanding of the mechanism of Hp related gastrointestinal tract diseasess, especially gastric cancer.
4

Effect of apelin on mitosis, apoptosis and DNA repair enzyme OGG 1/2 expression in intestinal cell lines IEC-6 and Caco-2

84%
Antushevich H., Krawczynska B., Kapica M., Herman A. P., Zabielski R.
Folia Histochemica et Cytobiologica
|
2014
|
tom 52
|
nr 1
5

Distributions of PCNA and Cas-3 in rat uterus during early pregnancy

84%
Oner H., Oner J., Demir R.
Folia Histochemica et Cytobiologica
|
2010
|
tom 48
|
nr 1
71-77
6

Myenteric plexuses atrophy in the vicinity of colorectal cancer tissue is not caused by apoptosis or necrosis

84%
Kozlowska A., Kwiatkowski P., Oponowicz A., Majewski M., Kmiec Z., Godlewski J.
Folia Histochemica et Cytobiologica
|
2016
|
tom 54
|
nr 2
7

Pterostilbene induces cell cycle arrest and apoptosis in MOLT4 human leukemia cells

84%
Siedlecka-Kroplewska K., Jozwik A., Kaszubowska L., Kowalczyk A., Boguslawski W.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 4
8

Changes of Bcl-2, Bax and Caspase-3 expression in the dermal microvascular endothelial cells and the epidermal layers of the eschar (tache noire) in patients with Mediterranean spotted fever

84%
Baltadzhiev I., Delchev S.
Folia Histochemica et Cytobiologica
|
2013
|
tom 51
|
nr 2
9

The miR-1204 regulates apoptosis in NSCLC cells by targeting DEK

84%
Qian Z., Yang J., Liu H., Yin Y., Hou L., Hu H.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 2
10

Immunohistochemical expression of apoptotic factors, cytokeratins, and metalloproteinase-9 in periapical and epithelialized gingival lesions

84%
Leone A., Uzzo M. L., Rappa F., Hussein I. A. H., Gerbino A., Spatola G. F., Jurjus A.
Folia Histochemica et Cytobiologica
|
2012
|
tom 50
|
nr 4
11

Protein kinase C-delta in apoptosis: a brief overview

84%
Zhao M., Xia L., Chen G.-Q.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 5
12

Processes of apoptosis and cell proliferation in uterine myomas originating from reproductive and perimenopausal women

84%
Plewka A., Plewka D., Madej P., Nowaczyk G., Sieron-Stoltny K., Jakubiec-Bartnik B.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 3
13

Cytotoxic and apoptotic effect of nanoclinoptilolite on canine osteosarcoma cell lines

84%
Ulutas P. A., Kiral F., Ulutas B., Asici G. S. E.
Journal of Veterinary Research
|
2020
|
tom 64
|
nr 4
14

Changes of mitochondrial pathway in hypoxia-reoxygenation induced cardiomyocytes apoptosis

84%
He A., Wang J., Gui C., Jiang Y., Sun Y., Chen T.
Folia Histochemica et Cytobiologica
|
2007
|
tom 45
|
nr 4
397-400
15

MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1

84%
Meng L., Cao H., Wan C., Jiang L.
Folia Histochemica et Cytobiologica
|
2019
|
tom 57
|
nr 4
16

Caspase-3 as an important factor in the early cytotoxic effect of nickel on oral mucosa cells in patients treated orthodontically

84%
Buczko P., Szarmach I., Grycz M., Kasacka I.
Folia Histochemica et Cytobiologica
|
2017
|
tom 55
|
nr 1
17

The induction of apoptosis by daunorubicin and idarubicin in human trisomic and diabetic fibroblasts

84%
Dragojew S., Marczak A., Maszewski J., Ilnicki K., Jozwiak Z.
Cellular and Molecular Biology Letters
|
2008
|
tom 13
|
nr 2
182-194
In this study, we investigated apoptosis induced in human trisomic and diabetic fibroblasts by daunorubicin (DNR) and its derivative, idarubicin (IDA). The cells were incubated with DNR or IDA for 2 h and then cultured in a drug-free medium for a further 2–48 h. The apoptosis in the cultured cell lines was assessed by biochemical analysis. We found that both drugs induced a timedependent loss of mitochondrial membrane potential, and a significant increase in intracellular calcium and caspase-3 activity. Mitochondrial polarization and changes in the level of intracellular calcium were observed during the first 2–6 h after drug treatment. Caspase-3 activation occurred in the late stages of the apoptotic pathway. Our findings also demonstrated that idarubicin was more cytotoxic and more effective than daunorubicin in inducing apoptosis in trisomic and diabetic fibroblasts.
18

Anti-TNF antibodies do not induce the apoptosis of lamina propria mononuclear cells in uninflamed intestinal tissue in patients with Crohn’s disease

84%
Eder P., Lykowska-Szuber L., Krela-Kazmierczak I., Stawczyk-Eder K., Sterzynska K., Iwanik K., Majewski P., Zabel M., Linke K.
Folia Histochemica et Cytobiologica
|
2013
|
tom 51
|
nr 3
19

Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines

84%
Yang K. M., Pyo J. O., Kim G.-Y., Yu R., Han I. S., Ju S. A., Kim W. H., Kim B.-S.
Cellular and Molecular Biology Letters
|
2009
|
tom 14
|
nr 3
497-510
Although genetic factors are a well-known cause of colorectal cancer, environmental factors contribute more to its development. Despite advances in the fields of surgery, radiotherapy and chemotherapy, the cure rates for colon cancer have not substantially improved over the past few decades. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the principal pungent ingredient of hot chili pepper, has exhibited an anti-tumor effect in many cell types. However, the mechanisms responsible for the anti-tumor effect of capsaicin are not yet completely understood. In this study, we investigated whether capsaicin induces apoptosis in colon cancer cell lines. Capsaicin decreased cell viability in a dose-dependent manner in Colo320DM and LoVo cells. In addition, capsaicin produced cell morphology changes and DNA fragmentation, decreased the DNA contents, and induced phosphatidylserine translocation, which is a hallmark of apoptotic cell death. We showed that capsaicin-induced apoptosis is associated with an increase in ROS generation and a disruption of the mitochondrial transmenbrane potential. A possible mechanism of capsaicin-induced apoptosis is the activation of caspase 3, a major apoptosis-executing enzyme. Treatment with capsaicin induced a dramatic increase in caspase 3 activity, as assessed by the cleavage of Ac-DEVD-AMC, a fluorogenic substrate. In conclusion, our results clearly showed that capsaicin induced apoptosis in colon cancer cells. Although the actual mechanisms of capsaicin-induced apoptosis remain uncertain, it may be a beneficial agent for colon cancer treatment and chemoprevention.
20

Histological and developmental study of prehierarchical follicles in geese

84%
Dong X., Liu H. H., Wang J. W., Xiao Q. H., Yuan X., Li L., Xia L., Li L.
Folia Biologica
|
2014
|
tom 62
|
nr 3
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