Wyniki wyszukiwania

1

Influence of age on the immediate heart rate response to the active orthostatic test

100%

Cybulski G., Niewiadomski W.

Journal of Physiology and Pharmacology

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2003

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tom 54

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nr 1

Dynamics of the heart rate changes following standing up from the supine position was investigated in 41 healthy men aged 20 to 59 years, classified according to the age into three groups: (22 to 26 yrs, n=14), (33 to 49, yrs, n=13) and (51 to 59 yrs, n=14). The protocol consisted of twice repeated sequence: lying down - standing up - lying down. The subjects remained in each position for 8 minutes. The average and beat-to-beat heart rate (HR) were continuously calculated using the specialized computer program analysing ECG. The initial response was analysed using both the indices known from literature and newly introduced by the authors. The high reproducibility of the response was observed and the correlations between the indices were analysed. The relationship between the indices characterising the pattern of the response and age were analysed using the linear regression model. Most of these indices showed a tendency towards attenuation of the HR response with age. The closest correlation with age was found for the index characterising the initial increase of HR after standing up (r=-0.610, p<0.001). There were no correlations between the indices of HR response to standing up and the height or body mass of the healthy subjects.

2

Involvement of platelet activating factor in immediate heart response to lipopolysaccharide

86%

Jakubowski A., Olszanecki R., Chlopicki S.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 2

Although lipopolysaccharide (LPS) is recognized to induce a biphasic cardiovascular response its mechanism is not fully elucidated. In this study we analysed the involvement of PAF, TXA2 and cysteinyl leukotrienes (cysLTs) in the acute cardiovascular effects of LPS in the isolated rat heart as well as in delayed phase of LPS response using a surrogate cellular model of the induction of NOS-2 by LPS in mouse macrophages. Perfusion of rat hearts with LPS resulted, in an immediate fall in heart contractility and coronary flow by 2.5 ± 0.59 ml min-1 and 560 ± 81 mmHg sec-1, respectively. This response was fully blocked by platelet activating factor (PAF) antagonist - WEB 2170 and partially inhibited, by inhibitor of cyclooxygenase (indomethacin) or by inhibitor of thromboxane synthase (camonagrel). The inhibition of leukotriene synthesis (BAY x1005) or cysLTs receptors (BAY x7195) was without effect. Administration of stable PAF analog (methylcarbamyl-PAF - MC-PAF) alone, mimicked heart response to LPS. In cultured mouse macrophages, MC-PAF did not induce NOS-2 expression and when given with LPS it slightly potentiated NOS-2 induction by LPS. However, in presence of WEB 2170 NOS-2 induction by LPS was inhibited in a dose-dependent manner. Inhibition of cyclooxygenase and leukotriene pathways had no effect on NOS-2 induced by LPS. These results indicate that PAF and TXA2 but not cysLTs mediate the instant heart response induced by LPS, while PAF alone mediates a delayed NOS-2 induction by LPS. Accordingly, PAF may constitute the mediator that links acute and delayed phases of LPS-induced cardiovascular response.

3

Cardiovascular and neurohormonal responses to lower body negative pressure [LBNP]: effect of training and 3 day bed rest

72%

Gasiorowska A., Mikulski T., Smorawinski J., Kaciuba-Uscilko H., Cybulski G., Zieba A. W., Krzeminski K., Niewiadomski W., Nazar K.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 10

85-100

Both intensive training and bed confinement impair orthostatic tolerance, however, moderate training may exert beneficial effect on cardiovascular adjustment to gravitational stimuli. It was hypothesized that moderate training attenuates effects of bed rest. To test this assumption 24 healthy male volunteers aged 20.8±0.9 yrs were subjected to 6° head down bed rest (HDBR) for 3 days before and after 6 weeks of moderate endurance training. Before and after HDBR graded LBNP tests (-15, -30, -50 mmHg) were performed. During these tests heart rate (HR), stroke volume (SV), blood pressure (BP), plasma catecholamines, ACTH, adrenomedullin, atrial natriuretic peptide, plasma renin activity (PRA) and hematocrit were determined. HDBR did not systematically influence LBNP tolerance up to -50 mmHg, but it enhanced rates of reduction of SV, cardiac output and systolic BP and increased elevations of HR and PRA. Training did not alter significantly effects of HDBR on LBNP-induced changes in HR, SV, CO and TPR but it attenuated decrease in systolic BP and diminished increases in plasma noradrenaline and PRA. In conclusion, training has negligible effect on the HDBR-induced changes in central hemodynamics during LBNP but may increase vascular sensitivity to some vasoconstricting factors.

4

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The influence of endurance training on the transient haemodynamic response to orthostatic manoeuvre

72%

Cybulski G., Krzeminski K., Niewiadomski W., Nazar K.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 2

5

Role of neuropeptides in central control of cardiovascular responses to stress

58%

Szczepanska-Sadowska E.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 8

6

Cardiovascular response to vestibular stimulation in cyclic, situational and stereotypical complex coordination kinds of sports

58%

Nazarenko A. S., Chinkin A. S.

Central European Journal of Sport Sciences and Medicine

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2014

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tom 05

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nr 1

The aim of the work is the study of the dependence of cardiovascular system reaction to the vestibular stimulation on the peculiarities of movements in the above-mentioned kinds of sports. Vestibular reactions of 108 males were studied, 93 of which were involved in cyclic (middle and long distance jogging, cross-country skiing, swimming), situational (sports game) and difficult to coordinate movements of stereotypical sports (gymnastics). The above facts indicate that sports contribute to the adaptation to vestibular load and, as a consequence, the development of less severe autonomic reactions to vestibular stimulation. It is essential that the vestibular resistance develops not only in those sports in which the motor activity abounds in a corner acceleration but also in those species sports where such similar accelerations are minimal. The influence of the specifics of the motor activity in some sports is reflected in the value of response in tests with a change of a head position.

7

Involvement of hindbrain and peripheral prostanoids in gastric motor and cardiovascular responses to delta-9-tetrahydrocannabinol in the rat

58%

Krowicki Z. K.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 6

8

Oxytocin in the cardiovascular responses to stress

58%

Wsol A., Cudnoch-Jedrzejewska A., Szczepanska-Sadowska E., Kowalewski S., Puchalska L.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 8

9

Behavioral, ultrasonic, and cardiovascular responses of male wistar rats in different social and emotional contexts after ultrasonic playback

58%

Filipkowski R. K.

Acta Neurobiologiae Experimentalis

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2019

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tom 79

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nr Suppl.1

Rats are social animals that use ultrasonic vocalizations (USV) to communicate. USV are usually divided into 50 kHz calls which accompany appetitive states, and 22 kHz vocalizations which are usually associated with aversive states. Both kinds of states are known to affect animals’ heart rate (HR). Also, the polyvagal theory claims that both cardiovascular parameters and USV emission is affected by the autonomous system, as they share a common signaling pathway. The aim of the study was to evaluate the changes in behavior, HR, and USV emission after playback of ultrasounds. Male Wistar rats were housed in pairs or separately for 4 weeks, and some of the animals underwent fear conditioning. Animals were implanted with DSI telemetry transmitters for acquisition of cardiovascular parameters. After recovery, rats were subjected to ultrasounds playback consisting of initial 10 min of static silence and five sets of 10 s sounds (50 or 22 kHz), either natural, collected from animals, or artificial tones, separated by 5 min silence intervals. Video, audio, and cardiovascular parameters were collected. Surprisingly, presentation of both 50 and 22 kHz sounds induced approach behavior. Both single- and pair-housed animals responded with a larger number of USV to both natural and artificial 50 kHz sounds playback rather than to 22 kHz sounds. The emitted USV were, almost exclusively, within the 50 kHz range. Animal HR levels decreased gradually during the experimental session. Single‑housed animals had, in general, higher HR than paired rats. There was an impact of every kind of ultrasonic presentation on HR levels; in general, 50 kHz ultrasonic playback caused a sudden increase in HR, whereas 22 kHz presentations evoked a HR drop. Surprisingly, USV and artificial tones had similar effects on HR and USV responses. Social context did not appear to alter rats’ USV emission. The results following fear conditioning are being analyzed. Also, in a separate set of experiments, rats ultrasonic responses were analyzed following presentation of a defined number of pre‑recorded USV.

10

Cardiovascular, metabolic and plasma catecholamine responses to passive and active exercises

58%

Krzeminski K., Kruk B., Nazar K., Ziemba A. W., Cybulski G., Niewiadomski W.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 2

11

Substrate oxidation at rest and during exercise: effects of menstrual cycle phase and diet composition

58%

Wenz M., Berend J. Z., Lynch N. A., Chappell S., Hackney A. C.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 4

Ograniczanie wyników

Influence of age on the immediate heart rate response to the active orthostatic test

Involvement of platelet activating factor in immediate heart response to lipopolysaccharide

Cardiovascular and neurohormonal responses to lower body negative pressure [LBNP]: effect of training and 3 day bed rest

The influence of endurance training on the transient haemodynamic response to orthostatic manoeuvre

Role of neuropeptides in central control of cardiovascular responses to stress

Cardiovascular response to vestibular stimulation in cyclic, situational and stereotypical complex coordination kinds of sports

Involvement of hindbrain and peripheral prostanoids in gastric motor and cardiovascular responses to delta-9-tetrahydrocannabinol in the rat

Oxytocin in the cardiovascular responses to stress

Behavioral, ultrasonic, and cardiovascular responses of male wistar rats in different social and emotional contexts after ultrasonic playback

Cardiovascular, metabolic and plasma catecholamine responses to passive and active exercises

Substrate oxidation at rest and during exercise: effects of menstrual cycle phase and diet composition