Wyniki wyszukiwania

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Post-transcriptional modifications of VEGF-A mRNA in non-ischemic dilated cardiomyopathy

100%

Kowalczyk J., Domal-Kwiatkowska D., Mazurek U., Zembala M., Michalski B., Zembala M.

Cellular and Molecular Biology Letters

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2007

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tom 12

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nr 3

Vascular endothelial growth factor (VEGF-A) is one of the most important proangiogenic factors. It has many isoforms encoded by one gene. The occurrence of these isoforms is associated with the process of alternative splicing of mRNA. Some of the splice forms are perceived as tissue specific. The aim of this study was to determine the alternative splicing of VEGF-A mRNA in dilated cardiomyopathy, especially at the level of particular myocardial layers. The assessment of post-transcriptional modifications of VEGF-A mRNA was made on specimens taken from the explanted hearts of patients undergoing cardiac transplantation. Molecular and histopathological studies were perfomed on particular layers of the myocardial muscle (endocardium, myocardium, epicardium). A molecular analysis of cardiac samples was performed by quantitative analysis of the mRNA of the studied VEGF-A isoforms (VEGF121, -145, -165, -183, -189, and -206) using QRTPCR with an ABI-PRISM 7700-TaqMan sequence detector. 72 cardiac specimens taken from the explanted hearts were analyzed. Each of the studied VEGF-A splice forms was present in the evaluated hearts, but the types of alternative splicing of mRNA were different in particular layers. Quantitative analysis revealed different amounts of the studied isoforms. Generally, significantly increased expression of the VEGF-A isoforms was observed in samples taken from hearts with post-inflammatory etiology of cardiomyopathy. Our conclusions are: 1. All the studied VEGF-A isoforms were found in the human hearts, including those thusfar considered characteristic for other tissues. 2. Significant differences were observed in the expression of the VEGF-A splice forms with respect to the myocardial layers and the location of the cardiac biopsy. 3. Repetitive and comparable results for samples with post-inflammatory etiology were obtained, and they revealed considerably higher amounts of VEGF-A isoforms compared to specimens with idiopathic etiology.

2

A new face of endocannabinoids in pharmacotherapy. Part II: Role of endocannabinoids in inflammation-derived cardiovascular diseases infarction

84%

Zubrzycki M., Liebold A., Janecka A., Zubrzycka M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 2

3

Cardiomyocyte marker expression in dogs with left atrial enlargement due to dilated cardiomyopathy or myxomatous mitral valve disease

84%

Janus I., Kandefer-Gola M., Ciaputa R., Noszczyk-Nowak A., Paslawska U., Tursi M., Nowak M.

Folia Histochemica et Cytobiologica

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2017

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tom 55

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nr 2

4

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Cardiohepatic interactions - cirrhotic cardiomyopathy and cardiac cirrhosis

84%

Witczak A., Prystupa A., Ollegasagrem S., Dzida G.

Journal of Pre-Clinical and Clinical Research

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2015

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tom 09

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nr 1

Interactions between the heart and the liver have been under investigation for many years. Cirrhotic cardiomyopathy characterized by hyperdynamic and hyporeactive circulation has been described in patients with advanced liver disease. Liver disease due to heart failure comprises acute hypoxic hepatitis due to reduced hepatic blood flow and congestive hepatopathy due to increased pressure within hepatic veins. Despite some specific characteristics, clinical presentation and treatment of cirrhotic heart disease and cardiac liver diseases are similar to the management of heart failure and liver cirrhosis of other origin.

5

Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling

84%

Altamimi J. Z., Alfaris N. A., Alshammari G. M., Alagal R. I., Aljabryn D. H., Aldera H., Alkhateeb M. A., Yahya M. M.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 6

6

Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

84%

Tomaszek A., Kiczak L., Bania J., Paslawska U., Zacharski M., Janiszewski A., Noszczyk-Nowak A., Dziegiel P., Kuropka P., Ponikowski P., Jankowska E. A.

Journal of Physiology and Pharmacology

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2015

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tom 66

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nr 2

7

Three novel mutations in exon 21 encoding beta-cardiac myosin heavy chain

84%

Moric E., Mazurek U., Polonska J., Domal-Kwiatkowska D., Smolik S., Kozakiewicz K., Tendera M., Wilczok T.

Journal of Applied Genetics

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2003

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tom 44

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nr 1

8

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

67%

Zhang Y.-W., Shi J., Li Y.-J., Wei L.

Archivum Immunologiae et Therapiae Experimentalis

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2009

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tom 57

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nr 6

435-445

9

Echocardiographic evaluation of diastolic parameters in dogs with dilated cardiomyopathy

67%

Garncarz M. A.

Polish Journal of Veterinary Sciences

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2007

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tom 10

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nr 4

Echocardiography is a valuable tool for the evaluation of systolic and diastolic cardiac function. A high correlation between measurements of diastolic mitral inflow parameters analyzed with Doppler echocardiography and invasive methods makes the former valuable. The aim of this study was to ascertain if significant differences occur in diastolic myocardial parameters between dogs with no heart disease and dogs with subclinical or clinical dilated cardiomyopathy. Furthermore the aim of the study was to determine whether heart failure in dilated cardiomypathy is a result of systolic dysfunction alone or both systolic and diastolic dysfunction. Eleven parameters were analyzed: E wave, E-AT, E-DT, E time, A wave, A-AT, A-DT, A time, E+A time, E/A ratio, and IVRT. The study confirmed the value of noninvasive echocardiographic assessment of diastolic function in dogs with dilated cardiomyopathy. Significant differences were found in E wave, E-AT, E time, E/A ratio and IVRT between healthy dogs and dogs with dilated cardiomyopathy. All are characterized by a significant decrease compared to healthy dogs after taking into account age and body weight except for the E/A ratio, which significantly increased in value. There were no significant changes in any of the Doppler parameters for diastolic evaluation in subclinical cases of DCM. Advanced heart failure in dilated cardiomyopathy entails systolic and diastolic dysfunction.

10

Autoimmunity and heart diseases: pathogenesis and diagnostic criteria

67%

Nussinovitch U., Shoenfeld Y.

Archivum Immunologiae et Therapiae Experimentalis

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2009

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tom 57

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nr 2

95-104

11

Myosins and pathology: genetics and biology

67%

Redowicz M. J.

Acta Biochimica Polonica

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2002

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tom 49

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nr 4

This article summarizes current knowledge on the genetics and possible molecular mechanisms of human pathologies resulted from mutations within the genes encoding several myosin isoforms. Mutations within the genes encoding some myosin isoforms have been found to be responsible for blindness (myosins III and VIIA), deafness (myosins I, IIA, IIIA, VI, VIIA and XV) and familial hypertrophic cardiomyopathy (β cardiac myosin heavy chain and both the regulatory and essential light chains). Myosin III localizes predominantly to photoreceptor cells and is proved to be engaged in the vision process in Drosophila. In the inner ear, myosin I is postulated to play a role as an adaptive motor in the tip links of stereocilia of hair cells, myosin IIA seems to be responsible for stabilizing the contacts between adjacent inner ear hair cells, myosin VI plays a role as an intracellular motor transporting membrane structures within the hair cells while myo- sin VIIA most probably participates in forming links between neighbouring stereocilia and myosin XV probably stabilizes the stereocilia structure. About 30% of patients with familial hypertrophic cardiomyopathy have mutations within the genes encoding the β cardiac myosin heavy chain and both light chains that are grouped within the regions of myosin head crucial for its functions. The alterations lead to the destabilization of sarcomeres and to a decrease of the myosin ATPase activity and its ability to move actin filaments.

Ograniczanie wyników

Post-transcriptional modifications of VEGF-A mRNA in non-ischemic dilated cardiomyopathy

A new face of endocannabinoids in pharmacotherapy. Part II: Role of endocannabinoids in inflammation-derived cardiovascular diseases infarction

Cardiomyocyte marker expression in dogs with left atrial enlargement due to dilated cardiomyopathy or myxomatous mitral valve disease

Cardiohepatic interactions - cirrhotic cardiomyopathy and cardiac cirrhosis

Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling

Increased gene expression of catecholamine-synthesizing enzymes in adrenal glands contributes to high circulating catecholamines in pigs with tachycardia-induced cardiomyopathy

Three novel mutations in exon 21 encoding beta-cardiac myosin heavy chain

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

Echocardiographic evaluation of diastolic parameters in dogs with dilated cardiomyopathy

Autoimmunity and heart diseases: pathogenesis and diagnostic criteria

Myosins and pathology: genetics and biology