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1

Cannabinoid-like anti-inflammatory compounds from flax fiber

100%
Styrczewska M., Kulma A., Ratajczak K., Amarowicz R., Szopa J.
Cellular and Molecular Biology Letters
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2012
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tom 17
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nr 3
Flax is a valuable source of fibers, linseed and oil. The compounds of the latter two products have already been widely examined and have been proven to possess many health-beneficial properties. In the course of analysis of fibers extract from previously generated transgenic plants overproducing phenylpropanoids a new terpenoid compound was discovered. The UV spectra and the retention time in UPLC analysis of this new compound reveal similarity to a cannabinoid-like compound, probably cannabidiol (CBD). This was confirmed by finding two ions at m/z 174.1 and 231.2 in mass spectra analysis. Further confirmation of the nature of the compound was based on a biological activity assay. It was found that the compound affects the expression of genes involved in inflammatory processes in mouse and human fibroblasts and likely the CBD from Cannabis sativa activates the specific peripheral cannabinoid receptor 2 (CB2) gene expression. Besides fibers, the compound was also found in all other flax tissues. It should be pointed out that the industrial process of fabric production does not affect CBD activity. The presented data suggest for the first time that flax products can be a source of biologically active cannabinoid-like compounds that are able to influence the cell immunological response. These findings might open up many new applications for medical flax products, especially for the fabric as a material for wound dressing with anti-inflammatory properties.
2

Cannabinoids enhance gastric X-A - like cells activity

100%
Zbucki R. L., Sawicki B., Hryniewicz A., Winnicka M. M.
Folia Histochemica et Cytobiologica
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2008
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tom 46
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nr 2
219-224
3
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Micropropagation of monoecious fibrous hemp based on experiments with a Polish variety Bialobrzeskie

100%
Luwanska A., Mankowska G., Wielgus K.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2015
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tom 96
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nr 1
4
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Weather factors and basic nutrient requirements for the cultivation of industrial hemp (Cannabis sativa L.)

100%
Strzelczyk M., Chudy M.
Zeszyty Problemowe Postępów Nauk Rolniczych
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2020
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tom 601
5

Środki odurzające w aptece na ziemiach polskich w XX wieku na przykładzie opioidów i kannabinoidów

100%
Pyzio M.
Analecta. Studia i Materiały z Dziejów Nauki
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2014
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tom 23
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nr 2
6

CB1 receptor antagonism in hedonic homeostasis

100%
Nomikos G.
Acta Neurobiologiae Experimentalis
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2005
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tom 65
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nr 5
7
Content available remote

Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide

80%
Engel M. A., Kellermann C. A., Rau T., Burnat G., Hahn E. G., Konturek P. C.
Journal of Physiology and Pharmacology
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2008
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tom 59
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nr 4
673-689
Anti-inflammatory and anti-nociceptive properties of endocannabinoids and synthetic cannabinoid compounds were described previously. We studied effects of the endogenous cannabinoid anandamide (N-arachidonylethanolamine) in experimental colitis induced by TNBS (2,4,6-trinitrobenzene sulfonic acid) in AKR mice. A scoring system was used to describe clinical and macroscopic changes. Intraperitoneally administered anandamide significantly reduced experimental colitis, quantified by macroscopical and histological scoring systems as well as pro-inflammatory cytokine mRNA expression. We conclude that systemically administered anandamide attenuates TNBS colitis in mice, and that systemically active cannabinoid compounds might have therapeutic potential for the treatment of IBD.
8
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Importance of cannabinoids in the functioning of the central nervous system

80%
Wroblewska-Luczka P., Florek-Luszczki M., Luszczki J. J.
Health Problems of Civilization
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2018
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tom 12
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nr 3
At present, there is a great emphasis of public opinion on the legalisation of medical marijuana, i.e. the top parts of the cannabis plants rich in tetrahydrocannabinol (THC). Nevertheless, in the cannabis plants, there are many various cannabinoids, including cannabidiol (CBD). Scientific reports to-date indicate the possibility for using pharmacologically active cannabinoids in the treatment of such diseases/symptoms as: anorexia, vomiting, neuropathic pain, inflammatory diseases, multiple sclerosis, degenerative diseases of the central nervous system (Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, Tourette’s syndrome), epilepsy, schizophrenia, and obesity. The article presents up-to-date information on the results of experimental studies concerning the effectiveness of cannabinoids, with particular consideration of diseases related with the central nervous system, including epilepsy, neuropathic pain, mental disorders, as well as obesity and anorexia.
9

Effects of CP 55,940 — agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas

80%
Kasacka I., Arciszewska E., Winnicka M. M., Lewandowska A.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 1
10
Content available remote

Combined stimulation of glucagon-like peptide-1 receptor and inhibition of cannabinoid CB1 receptor act synergistically to reduce food intake and body weight in the rat

80%
Bojanowska E., Radziszewska E.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 4
11
Content available remote

Role of sensory nerves in gastroprotective effect of anandamide in rats

80%
Warzecha Z., Dembinski A., Ceranowicz P., Dembinski M., Cieszkowski J., Kownacki P., Konturek P. C.
Journal of Physiology and Pharmacology
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2011
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tom 62
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nr 2
Previous studies have shown that stimulation of cannabinoid 1 (CB1) receptor protects the gastric mucosa against stress-induced lesion. Aim of the present study was to examine the influence of anandamide on lipid peroxidation and antioxidant defense system in gastric mucosa and the role of sensory nerves in gastroprotective effects of cannabinoids. Studies were performed on rats with intact or ablated sensory nerves (by neurotoxic doses of capsaicin). Gastric lesions were induced by water immersion and restrain stress (WRS). Anandamide was administered at the dose of 0.3, 1.5 or 3.0 µmol/kg, 30 min before exposure to WRS. CB1 receptor antagonist, AM251 (4.0 µmol/kg) was administered 40 min before WRS. WRS induced gastric lesions associated with the decrease in gastric blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD). Serum level of interleukin-1ß (IL-1ß) and mucosal level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were increased. Administration of anandamide reduced the ulcers area, generation of MDA+4-HNE and serum level of IL-1ß, and this effect was associated with the reduction in the WRS-induced decrease in gastric mucosal blood flow, mucosal DNA synthesis and SOD activity. Ablation of sensory nerves increased the area of ulcers, serum level of IL-1ß and mucosal content of MDA+4-HNE, whereas mucosal DNA synthesis, SOD activity and blood flow were additionally decreased. In rats with ablation of sensory nerves, administration of anandamide at the high doses (1.5 and 3.0 µmol/kg) partly reduced deleterious effect of WRS on gastric mucosa, but this effect was weaker than in animals with intact sensory nerves. Low dose of anandamide (0.3 µmol/kg) was ineffective in the protection of gastric mucosa against the WRS-induced lesions in rats with ablation of sensory nerves. In rats with intact sensory nerves and exposed to WRS, administration of AM251 exhibited deleterious effect. In rats with ablation of sensory nerves and exposed to WRS, AM251 failed to affect mucosal injury in the stomach. We conclude that anandamide reduces the mucosal oxidative stress and exhibits gastroprotective effect against WRS-induced ulcers. These effects are partly mediated by sensory nerves.
12
Content available remote

Interaction between orexin A and cannabinoid system in the lateral hypothalamus of rats and effects of subchronic intraperitoneal administration of cannabinoid receptor inverse agonist on food intake and the nutritive utilization of protein

80%
Merroun I., El Mlili N., Martinez R., Porres J. M., Llopis J., Ahabrach H., Aranda P., Sanchez Gonzalez C., Errami M., Lopez-Jurado M.
Journal of Physiology and Pharmacology
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2015
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tom 66
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nr 2
13
Content available remote

Analysis of the effect of neuropeptides and cannabinoids in gastric mucosal defense initiated centrally in the rat

61%
Shujaa N., Zadori Z. S., Ronai A. Z., Barna I., Mergl Z., Mozes M. M., Gyires K.
Journal of Physiology and Pharmacology. Supplement
|
2009
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tom 60
|
nr 7
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