Ograniczanie wyników

Czasopisma help
Autorzy help
Lata help
Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 534

Liczba wyników na stronie
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 27 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych:  calcium
help Sortuj według:

help Ogranicz wyniki do:
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 27 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
Mitochondrial NADP-specific isocitrate dehydrogenase (ICDH) partially purified from rabbit adrenals is sensitive to low concentrations of Ca2+. In the absence of Ca2+ (addition of 1 mM EGTA) the Km of ICDH for DL-isocitrate was 143 jaM, and in the presence of about 10 jaM Ca2+ (EGTA-Ca2+ buffer) it was decreased to 55 ¿iM. The JCm value of ICDH for NADP was similar in the absence (4.4 jxM) and in the presence (5.0 jiM) of Ca2+. The Km of mitochondrial NADP-ICDH for DL-isocitrate was higher than that of cytoplasmic NADP-ICDH from the same source.
This study aimed to assess whether nicotine prevented glutamate neurotoxicity in PC12 cells, and to identify the molecular mechanisms of any effects. The results showed that glutamate neurotoxicity in PC12 cells could be prevented by treatment with nicotine at concentrations of 10 nmol.l-1-1 mmol.l-1. This effect was in turn found to be inhibited by the application of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine. Nicotine significantly decreased the basal level of intracellular free Ca2+ and enhanced the buffering action on Ca2+ overload induced by high concentrations of glutamate (5 mmol.l-1). In addition, nicotine treatment up-regulated the mRNA and protein expression of apoptosis-related factors including bcl-2 mRNA and protein, but down-regulated the expression of bax mRNA and protein. It is concluded that the protective effects of nicotine against the neurotoxicity induced by glutamate are mediated by nAChRs, due to the increased buffering action on Ca2+ and the modulation of apoptotic processes.
The manufacturing of compound fertilizers enriched with calcium by solid component granulation using by-product of beet sugar industry – sugar factory lime (SFL) was investigated on laboratory scale. Sugar factory lime was examined by chemical, differential scanning calorimetry – thermogravimetry (DSC -TG), infrared spectroscopy (IR ) and X-ray diffraction (XRD) analysis. The dependence of particle size and crushing strength on SFL content, fertilizers component ratio and recycling part of fertilizers in granulation mixture was obtained. The main physicochemical properties of fertilizers such as particle size distribution, moisture content, pH, and particle crushing strength are determined. The results of investigations show, that waste from the beet sugar industry may be used in production of compound fertilizers as a calcium source. The results obtained are important for environmental protection and plant fertilization.
The plasma membrane is a specialised multi-component structure with inter- and intracellular signalling functions. Ca2+ plays a crucial role in cellular physiology, and an ATP-driven plasma membrane calcium pump (PMCA) plays the greatest role in the maintenance of a low free Ca2+ concentration in the cytoplasm. The enzyme is coded by four separate genes (PMCA 1-4), and, due to alternative splicing, more than 20 variants can exist. PMCA 1 and 4 isoforms are present in almost all tissues, whereas PMCA 2 and 3 are found in more specialised cell types. The variants differ primarily in their regulatory regions, thus the modulation of calcium pump activity strongly depends on the isoform and the membrane composition. The unique function of PMCA isoforms was confirmed using the practical experimental models - a rat pheochromocytoma cell line, a human neuroblastoma cell line, or, more recently, knockout mice. In addition, based on the finding that PMCA could interact with several specific signaling proteins, it was concluded that its location in defined sites of the cell membrane could be a prerequisite for efficient intercellular communication.
The content of the total calcium was studied in granulometric fractions of the following diameters: <0.002, 0.005-0.002, 0.02-0.005, 0.05-0.02, 0.1-0.05 and 1.0-0.1 mm. It was observed that the amount of Ca accumulated in particular fractions is not correlated with their content in soils. The ratios of Ca content in a given fraction to the content of the granulometric fraction (Ca/Fr) keep gradually decreasing from a clay fraction <0.002 to a sandy fraction of 0.1-1 mm. No calcium migration from the surface of the studied soils down the profile was observed in particular fractions, except for the clay fraction <0.002 mm in lessive soil profiles.
Pierwsza strona wyników Pięć stron wyników wstecz Poprzednia strona wyników Strona / 27 Następna strona wyników Pięć stron wyników wprzód Ostatnia strona wyników
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.