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  1. 6 Archivum Immunologiae et Therapiae Experimentalis

  2. 5 Folia Histochemica et Cytobiologica

  3. 5 Journal of Physiology and Pharmacology. Supplement

  4. 2 Lecznica Dużych Zwierząt. Ogólnopolski Kwartalnik dla Lekarzy Weterynarii

  5. 1 Acta Biochimica Polonica

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  1. 3 Chorostowska-Wynimko J.

  2. 2 Balicka-Slusarczyk B.

  3. 2 Chazan R.

  4. 2 Chyczewska E.

  5. 2 Jankowski M.

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  1. 2 2018

  2. 1 2016

  3. 1 2011

  4. 1 2010

  5. 1 2009

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1
Content available remote

The effect of fiberoptic bronchoscopy on exhaled nitric oxide

100%
Krenke R., Przybylowski T., Hildebrand K., Fangrat A., Gorska K., Barnas M., Chazan R.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
183-190
Nitric oxide has been extensively studied as a noninvasive marker of airway inflammation. Assuming that bronchoscopy can produce not only systemic but also local inflammatory response, we hypothesized that bronchofiberoscopy can be responsible for an increase in nitric oxide synthesis with resulting increase in fractional concentration of exhaled nitric oxide (FENO). Fifty five subjects (F/M-23/32; mean age 53.9 ±17.3 yr) undergoing diagnostic bronchoscopy participated in the study. The indications for bronchoscopy were as follows: interstitial lung diseases (n=13; 23.6%), lung cancer (n=11; 20.0%), hemoptysis (n=10; 18.2%), differential diagnosis of asthma/dyspnea (n=9; 16.4%), pulmonary infections (n=7; 12.7%), and others (n=5; 9.1%). During bronchoscopy bronchial washing (n=18), bronchoalveolar lavage (BAL) (n=26), and bronchial biopsies (n=24) were performed. FENO was analyzed on-line with chemiluminescence analyzer (NIOX, Aerocrine, Sweden) according to the ATS guidelines, before and at 1, 2, 3 and 24 h after bronchoscopy. The mean FENO before bronchoscopy was 21.0 ±3.31(SE) ppb, it decreased to 14.8 ±2.10 ppb 1 h after bronchoscopy, reached a nadir at 2 h (14.4 ±2.28 ppb; P<0.05), and was not different from baseline 24 h after bronchoscopy (22.8 ±2.90 ppb). There were no differences in the FENO profile in BAL patients compared with those in whom only the bronchial washing was performed. We conclude that bronchoscopy leads to a decrease in FENO. The underlying mechanisms are at present unclear.
2
Content available remote

Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis

100%
Chorostowska-Wynimko J., Lesniewska-Radomska D., Krychniak-Soszka A., Remiszewski P., Szopinski J., Wesolowski S., Kus J., Skopinska-Rozewska E.
Journal of Physiology and Pharmacology. Supplement
|
2004
|
tom 55
|
nr 3
41-47
Sarcoidosis is a chronic inflammatory multiorgan disease of unknown origin. Our previous study demonstrated a significant correlation between the relative count of nonCD4+, nonCD8+ lymphocytes in bronchoalveolar lavage of active sarcoidosis patients and proangiogenic activity of BAL homogenates. The aim of the present study was to evaluate in a group of 40 patients with active sarcoidosis the possible relationship between the intensity of alveolitis, particularly the nonCD4+, nonCD8+ lymphocyte subset, and other parameters characterizing the level of pulmonary (lung function tests) and extrapulmonary (spleen longitudinal dimension) disease activity. We found that the relative count of nonCD4+, nonCD8+ lymphocytes in BAL correlated positively with spleen size (r=0.50, P<0.01) and negatively with static compliance (r=0.43, P<0.05). We concluded that the lymphocytes belonging to the nonCD4+nonCD8+ subset participate in the inflammatory process in sarcoidosis. However, more detailed phenotypic and functional characteristics of this cellular population are needed.
3

Usefulness of the analysis of bronchoalveolar lavage (BAL) cellular composition in diagnosis and monitoring of pulmonary sarcoidosis treatment

100%
Szklarz E.
Archivum Immunologiae et Therapiae Experimentalis
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1989
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tom 37
|
nr 1-2
4

Effect of heparin on the course of sulphur dioxide induced bronchitis in rats

100%
Krasnowska M., Kwasniewski A., Rabczynski J., Fal A., Kuryszko J.
Archivum Immunologiae et Therapiae Experimentalis
|
1998
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tom 46
|
nr 1
5
Content available remote

Effects of budesonide on the lung functions, inflammation and apoptosis in a saline-lavage model of acute lung injury

84%
Mokra D., Kosutova P., Balentova S., Adamkov M., Mikolka P., Mokry J., Antosova M., Calkovska A.
Journal of Physiology and Pharmacology
|
2016
|
tom 67
|
nr 6
6
Content available remote

Human cytomegalovirus DNA level in patients with idiopathic pulmonary fibrosis

84%
Dworniczak S., Ziora D., Kapral M., Mazurek U., Niepsuj G., Rauer R., Wilczok T., Kozielski J.
Journal of Physiology and Pharmacology. Supplement
|
2004
|
tom 55
|
nr 3
67-75
The objectives of the study were to estimate human cytomegalovirus (HCMV) DNA copy number in broncho-alveolar lavage cells, blood leukocytes, and serum of patients with idiopathic pulmonary fibrosis (IPF). The study groups consisted of 16 patients, newly diagnosed with IPF and never treated, (mean age 40.9 ±11.0 yr; F/M-7/9) and in 16 adult healthy volunteers (mean age 36.8 ±6.4 yr; F/M-4/12) used as controls. The HCMV DNA copy number was calculated by a Q-PCR method using TaqMan ABI PRISMTM7700. We found that the prevalence of the HCMV DNA positive subjects in the patient group (75%) did not differ significantly from that in the control group (69%). We also found that in both patient and control groups the mean HCMV DNA copy number in BAL cells was significantly higher than that in blood leukocytes (log10=2.7 vs. 1.2 for patients and 2.8 vs. 0.9 for controls, respectively). However, a higher HCMV DNA copy number in blood serum was observed in IPF patients than in controls (log10=3.2 vs. 2.0, respectively). We conclude that the lungs play an important role in the human pathobiology of cytomegalovirus sustenance.
7

Idiopathic pulmonary fibrosis: Molecular mechanisms and possible therapeutic strategies

84%
Van Den Blink B., Jansen H. J., Peppelenbosch M. P.
Archivum Immunologiae et Therapiae Experimentalis
|
2000
|
tom 48
|
nr 6 Spec.Iss.
539-545
8

The role of PTEN in allergic inflammation

84%
Lee Y. C.
Archivum Immunologiae et Therapiae Experimentalis
|
2004
|
tom 52
|
nr 4
9

Childhood asthma: an inflammatory disease?

84%
Ennis M., Shields M. D.
Journal of Physiology and Pharmacology. Supplement
|
1997
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tom 48
|
nr 2
10

Effect of cyclosporin A on immunological response in lungs of guinea pigs infected with Trichinella spiralis

84%
Dzik J. M., Zielinski Z., Golos B., Jagielska E., Wranicz M., Walajtys-Rode E.
Acta Biochimica Polonica
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2002
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tom 49
|
nr 1
The effects of cyclosporin A (CsA), a potent immunosuppressive drug with anti­parasitic activity, on the innate immunological response in guinea pig lungs during an early period (6th and 14th days) after T. spiralis infection were studied. CsA treat­ment of T. spiralis-infected guinea pigs caused a significant attenuation of immuno- logical response in lungs by decreasing lymphocyte infiltration into pulmonary alveo­lar space, inhibiting alveolar macrophage superoxide anion production and lowering both the production of NO metabolites measured in bronchoalveolar lavage fluid and expression of the iNOS protein in lung homogenates, allowing us to speculate that the T. spiralis-dependent immunological response is dependent on lymphocyte T func­tion. Interestingly, CsA itself had a pro-inflammatory effect, promoting leucocyte ac­cumulation and macrophage superoxide production in guinea pig lungs. This observa­tion may have a relevance to the situation in patients undergoing CsA therapy. Macrophage expression of the iNOS protein, evaluated by immunoblotting was not in­fluenced by treatment of animals with CsA or anti-TGF-antibody, indicating different regulation of the guinea pig and murine enzymes.
11

A correlative study of bronchial cytology, bronchoalveolar lavage [BAL] and serum tumor markers in the diagnosis of lung carcinoma

84%
Niklinski J., Chyczewski L., Chyczewska E., Laudanski J., Furman M.
Folia Histochemica et Cytobiologica
|
1993
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tom 31
|
nr 4
12

Concentration of surfactant protein D, Clara cell protein CC-16 and IL-10 bronchoalveolar lavage [BAL] in patients with sarcoidosis, hypersensitivity pneumonitis and idiopathic pulmonary fibrosis

67%
Kucejko W., Chyczewska E., Naumnik W., Ossolinska M.
Folia Histochemica et Cytobiologica
|
2009
|
tom 47
|
nr 2
225-230
13

Bronchoalveolar lavage and evaluation of obtained BAL fluid in healthy dogs

67%
Spuzak J., Nicpon J., Kubiak K., Jankowski M.
Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine
|
2004
|
tom 07
|
nr 2
14

Enhanced expression of Fas Ligand (FasL) in the lower airways of patients with fibrotic interstitial lung diseases (ILDs)

67%
Kopinski P., Balicka-Slusarczyk B., Dyczek A., Szpechcinski A., Przybylski G., Jarzemska A., Wandtke T., Jankowski M., Iwaniec T., Chorostowska-Wynimko J.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 4
15
Content available remote

Inflammatory markers in the exhaled breath condensate of patients with pulmonary sarcoidosis

67%
Rozy A., Czerniawska J., Stepniewska A., Wozbinska B., Goljan A., Puscinska E., Gorecka D., Chorostowska-Wynimko J.
Journal of Physiology and Pharmacology. Supplement
|
2006
|
tom 57
|
nr 4
335-340
Pulmonary sarcoidosis may progress to fibrosis in some patients, so that close monitoring of its activity is essential for recommending clinical strategy. Examination of ariway inflammatory markers in bronchoalveolar lavage (BAL) is one of the methods applied to assess the disease severity. Recently, the expired breath condensate (EBC) has become another source of cytokines and mediators. In sarcoidosis, except for NO and oxidative stress markers, no other mediators have yet been estimated in the exhaled air. In the present study we attempted to answer the question of whether airway inflammatory markers in pulmonary sarcoidosis patients might be assessable in EBC and to what extend these markers might reflect the disease activity in the lungs IL-6, TNF-alpha, PAI-1, and IGF-1 were measured by Elisa method in EBC and BALF samples from 9 patients with newly-diagnosed pulmonary sarcoidosis. TNF-alpha, IGF-1, and PAI-1 levels in EBC and BAL samples were comparable and closely positively correlated [TNF-alpha (r=0.79, P<0.001), IGF-1 (r=0.94, P<0.001), and PAI-1 (r=0.81, P<0.001)]. In contrast, IL-6 concentration in EBC was significantly lower compared with that in BALF, while the correlation between both materials was negative (r=-0.47, P<0.05). An important distinction in IL-6 performance, which might explain this inconsistency, is its tendency to form more complex molecular forms of a higher weight than that of other cytokines. Our study shows that EBC reflects cytokine production in the lung as effectively as BALF, providing that the characteristics of proteins evaluated allow their easy transfer into the exhaled air. Further studies are required before accepting EBC samples as an equivalent to BALF.
16

Expression of insulin-like growth factor-I [IGF-I] in alveolar macrophages and lymphocytes obtained by bronchoalveolar lavage [BAL] in interstitial lung diseases [ILD]. Assessment of IGF-I as a potential local mitogen and antiapoptotic cytokine

67%
Kopinski P., Sladek K., Szczeklik J., Soja J., Szlubowski A., Balicka-Slusarczyk B., Lackowska B., Plato M., Szpechcinski A.
Folia Histochemica et Cytobiologica
|
2006
|
tom 44
|
nr 4
17

Comparison of leukocyte populations from bronchoalveolar lavage and induced sputum in the avaluation of cellular composition and nitric oxide production in patients with bronchial asthma

67%
Bienkowska-Haba M., Cembrzynska-Nowak M., Liebhart J., Dobek R., Liebhart E., Siemieniec I., Panaszek B., Obojski A., Malolepszy J.
Archivum Immunologiae et Therapiae Experimentalis
|
2002
|
tom 50
|
nr 1
18

Reactivity of alveolar macrophages in lung cancer patients and healthy subjects: surface ICAM-1 after INF-gamma stimulation in vitro

67%
Hoser G., Grubek-Jaworska H., Droszcz P., Domagala-Kulawik J., Dabrowska M., Chazan R.
Folia Histochemica et Cytobiologica
|
2002
|
tom 40
|
nr 2
19

Hypersensitivity pneumonitis in a gardener: persistent bronchoalveolar lavage lymphocytosis despite antigen avoidance

67%
Kirsten D., Nowak D., Kanzow G., Magnussen H.
Annals of Agricultural and Environmental Medicine
|
1994
|
tom 01
|
nr 1
20

The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease

59%
Fang C., Siew L. Q. C., Corrigan C. J., Ying S.
Archivum Immunologiae et Therapiae Experimentalis
|
2010
|
tom 58
|
nr 2
81-90
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