Wyniki wyszukiwania

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Immunohistochemical studies in diagnosis of the uncommon cases of tumours of the central nervous system

100%

Taraszewska A., Matyja E.

Folia Histochemica et Cytobiologica

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2002

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tom 40

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nr 2

2

Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik

Carbon nanoparticles as transporters of melittin to glioma grade IV U87 cells in in vitro model

84%

Biniecka P., Jaworski S., Bugajska Z., Daniluk K.

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

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2017

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tom 56[1]

Carbon nanoparticles as transporters of melittin to glioma cells in in vitro model.Substances derived from nature have natural cytotoxic properties, melittin, the main component of bee venom is one of them. It has the ability to destroy any lipid bilayer, therefore to be used in a cancer treatment it needs to be targeted. The aim is to create the drug delivery system, which would efficiently deliver the active substance to glioma cells. Carbon nanoparticles are considered to be a good agent in biomedical applications, due to their biocompatibility and small sizes. In this study five types of nanoparticles were used: pristine graphene (GN), nanographene oxide (nGO), graphite (G), nanodiamond (UDD) and hierarchical nanoporous carbons (HNCs) to target the melittin to cancer cells. The visualization of the drug delivery complexes of melittin and nanoparticles was done with transmission electron microscopy, the influence of the complexes on cell morphology and structure was pictured with scanning electron microscope. Moreover, in order to check the viability of the cells treated with melittin and the complexes of melittin and nanoparticles the PrestoBlueTM assay was done, also to specify the way of the cell death the annexin V/PI assay was carried out. The results indicate that various nanoparticles behave differently in a complex with melittin. The UDD, GN and nGO nanoparticles resulted in higher mortality than the melittin itself. Creating and applying such complexes of melittin with nanoparticles in glioma cancer treatment may be a promising solution in the therapy.

3

Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals

84%

Gomes A. C., Mello A. L., Ribeiro M. G., Garcia D. G., Da Fonseca C. O., D’Alincourt Salazar M., Schonthal A. H., Quirico-Santos T.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 4

4

Family with Li-Fraumeni syndrome and no evidence of a germline mutation of the p53 gene or chromosomal aberrations

84%

Sikorska A., Traczyk Z., Konopka L., Fiszer-Maliszewska L., Wojciechowska B., Pienkowska-Grela B., Rygier J., Woroniecka R., Witkowska A., Rusin M.

Journal of Applied Genetics

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2001

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tom 42

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nr 3

5

VCAM-1 expression on reactive and tumour astrocytes

84%

Kaluza J., Krupinski J., Kumar P., Kumar S., Wang J. M.

Folia Histochemica et Cytobiologica

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1994

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tom 32

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nr 1

6

Tumor infiltrating lymphocytes in malignant brain tumors

84%

Weber F., Volgmann T., Menzel J.

Archivum Immunologiae et Therapiae Experimentalis

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1993

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tom 41

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nr 1

7

Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies

67%

Agnihotri S., Burrell K. E., Wolf A., Jalali S., Hawkins C., Rutka J. T., Zadeh G.

Archivum Immunologiae et Therapiae Experimentalis

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2013

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tom 61

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nr 1

8

Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours

67%

Piccinni E., Chelstowska A., Hanus J., Widlak P., Loreti S., Tata A. M., Augusti-Tocco G., Bianchi M. M., Negri R.

Acta Biochimica Polonica

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2011

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tom 58

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nr 4

In order to understand better the role of the human Tip60 complex component Gas41, we analysed its expression levels in brain tumours and searched for possible interactors. Two-hybrid screening of a human foetal brain library allowed identification of some molecular interactors of Gas41. Among them we found n-Myc transcription factor. The interaction between Gas41 and n-Myc was validated by pull-down experiments. We showed that Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas. Finally, in order to identify which region of Gas41 is involved in the interaction with Myc proteins, we analysed the ability of Gas41 to substitute for its orthologue Yaf9 in yeast; we showed that the N-terminal portions of the two proteins, containing the YEATS domains, are interchangeable, while the C-terminal portions are species-specific. In fact we found that Gas41 C-terminal portion is required for Myc protein interaction in human.

Ograniczanie wyników

Immunohistochemical studies in diagnosis of the uncommon cases of tumours of the central nervous system

Carbon nanoparticles as transporters of melittin to glioma grade IV U87 cells in in vitro model

Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals

Family with Li-Fraumeni syndrome and no evidence of a germline mutation of the p53 gene or chromosomal aberrations

VCAM-1 expression on reactive and tumour astrocytes

Tumor infiltrating lymphocytes in malignant brain tumors

Glioblastoma, a brief review of history, molecular genetics, animal models and novel therapeutic strategies

Direct interaction of Gas41 and Myc encoded by amplified genes in nervous system tumours