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Detection of weak D antigen in the population of potential blood recipients

100%

Mitrus J. M., Adamiuk U.

Health Problems of Civilization

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2019

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tom 13

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nr 4

Background. The strongest immunogen of the Rh system is the D antigen. It is found in several variants and categories, which makes it difficult to determine the correct RhD (Rh+) or RhD negative (Rh-) phenotype. Although only some of the varieties and types of this antigen are of clinical significance, it is important to determine the normal Rh phenotype in recipients and donors. The aim of this study was to determine the frequency of weak D antigen in a population of potential recipients. Material and methods. The study group consisted of selected blood recipients in whom weak expression of the D antigen or its antibody was detected. In order to estimate the expression of antigen D, the blood was analyzed in the laboratory of the Regional Center of Blood Donation and Blood Treatment in Lublin. Blood from 220 potential recipients (149 women and 71 men) were used in the conducted research. The clinical material from the Laboratory of Transfusion Serology at the Provincial Specialist Hospital in Biała Podlaska was also used. Results. The presence of a weak D was confirmed in 21 recipients. 4 cases of weak D were confirmed among recipients of blood transplant, while 17 cases among those who did not have blood transfusions. There were significant differences in the occurrence of the weak D in relation to the transfusion in both women (χ² = 18.34 df = 2, p = 0.0001) and men (χ² = 17.25) . Conclusions. The correct determination of the RhD+ or RhD- phenotype is important for pregnant women who should be subjected to immunoprophylaxis of maternal-fetal conflict when a weak D is detected. In order to avoid post-transfusion complications among recipients, it is necessary to choose serologically and phenotypically crossed-matched blood components.

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Sildenafil, a phosphodiesterase type 5 inhibitor, downregulates osteopontin in human peripheral blood mononuclear cells

84%

Kaleta B., Boguska A.

Archivum Immunologiae et Therapiae Experimentalis

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2017

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tom 65

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nr 4

3

The estrogenic status and the COMT genotype of female blood donors influence the protective ability of the Mediterranean plant extracts against the hydrogen peroxide-induced DNA damage in lymphocytes

84%

Kapiszewska M., Zajac G., Kalemba M., Soltys E.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 1

199-217

The extent of oxidative DNA damage in lymphocytes can be used as a biomarker of the level of oxidative stress in the body. The comet assay has been widely used to measure such damage. The aim of our study was to evaluate: i) the extent of the oxidative DNA damage in lymphocytes isolated from blood of female donors taken in early and late follicular phases [low (LE) and high (HE) concentration of 17bestradiol, respectively], ii) the susceptibility of these lymphocytes to hydrogen peroxide exposure, and iii) the protective ability of five plant extracts against the hydrogen peroxide-induced DNA damage. The effect of the catechol-Omethytransferase genotype (wild COMT H/H and mutated homozygote COMT L/L) of female donors was also analyzed. The amount of endogenous DNA damage was higher in HE lymphocytes as compared with LE ones, independently of the genotype. When lymphocytes were stratified by COMT genotype, the level of DNA damage was higher in L/L donors. The protective effect of pretreatment with plant extracts (1 and 10 µg/ml for 1 h) against the H2O2 (25 µM, 5 min. at 4°C)-induced oxidative DNA damage was observed only in H/H HE lymphocytes. In contrary, the plant extract pre-incubation enhanced the DNA damage in L/L HE lymphocytes. The plant extracts alone did not induce the DNA damage. The results showed that concentration of the circulating 17b-estradiol influenced the extent of endogenous oxidative DNA damage while the beneficial or hazardous effects of the plant extracts might depend on the COMT genotype and the estrogen level.

4

Association between longevity and allelic forms of human leukocyte antigens [HLA]: population study of aged Italian human subjects

84%

Ricci G., Colombo C., Ghiazza B., Illeni M. T.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 1

5

HLA-A, B, C antigens in pulmonary sarcoidosis in Polish population

67%

Dubaniewicz A., Szczerkowska Z.

Archivum Immunologiae et Therapiae Experimentalis

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1999

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tom 47

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nr 1

6

Systemic humoral response to Helicobacter pylori in children and adults

67%

Chmiela M., Lawnik M., Czkwianianc E., Rechcinski T., Planeta-Malecka I., Rudnicka W.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 3

7

Lymphocyte interactions with extracellular matrix proteins and endothelium in renal allograft recipients

67%

Nowaczyk M., Gorski A., Korczak-Kowalska G., Wierzbicki P., Wyzgal J., Durlik M., Orlowska A.

Archivum Immunologiae et Therapiae Experimentalis

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1998

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tom 46

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nr 1

8

Hepatitis C virus [HCV] serotype in the asymptomatic HCV-infected patients from selected groups

67%

Pawlowska M., Halota W., Bulik F., Topczewska-Staubach E.

Archivum Immunologiae et Therapiae Experimentalis

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1997

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tom 45

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nr 5-6

9

Recurrent furunculosis: II.Immunotherapy with Propionibacterium granulosum KP-45

67%

Samochocki Z., Szmigielski S., Bacz-Malinowska M., Sokolska G., Soroko W., Jeljaszewicz J., Pulverer G.

Advances in Agricultural Sciences

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1992

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tom 01

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nr 1

Ograniczanie wyników

Detection of weak D antigen in the population of potential blood recipients

Sildenafil, a phosphodiesterase type 5 inhibitor, downregulates osteopontin in human peripheral blood mononuclear cells

The estrogenic status and the COMT genotype of female blood donors influence the protective ability of the Mediterranean plant extracts against the hydrogen peroxide-induced DNA damage in lymphocytes

Association between longevity and allelic forms of human leukocyte antigens [HLA]: population study of aged Italian human subjects

HLA-A, B, C antigens in pulmonary sarcoidosis in Polish population

Systemic humoral response to Helicobacter pylori in children and adults

Lymphocyte interactions with extracellular matrix proteins and endothelium in renal allograft recipients

Hepatitis C virus [HCV] serotype in the asymptomatic HCV-infected patients from selected groups

Recurrent furunculosis: II.Immunotherapy with Propionibacterium granulosum KP-45