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Contour contact area of the block and disk of the disk brake under the conditions of thermal deformations

100%

Golubenko A., Osenin Y. Y., Sosnov I.

Teka Komisji Motoryzacji i Energetyki Rolnictwa

2011

tom 11

Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein

80%

Bator J., Varga J., Berta G., Barbakadze T., Mikeladze D., Ramsden J., Szeberenyi J.

Cellular and Molecular Biology Letters

2012

tom 17

nr 3

Nitric oxide (NO) is a mediator of a diverse array of inter- and intracellular signal transduction processes. The aim of the present study was to analyze its possible role as a second messenger in the process of neuronal differentiation of PC12 pheochromocytoma cells. Upon NGF treatment wildtype PC12 cells stop dividing and develop neurites. In contrast, a PC12 subclone (designated M-M17-26) expressing a dominant-negative mutant Ras protein keeps proliferating and fails to grow neurites after NGF treatment. Sodium nitroprusside (SNP), an NO donor, was found to induce the p53 protein and to inhibit proliferation of both PC12 and M-M17-26 cells, but failed to induce neuronal differentiation in these cell lines. Key signaling pathways (the ERK and Akt pathways) were also not affected by SNP treatment, and the phosphorylation of CREB transcription factor was only slightly stimulated. It is thus concluded from the results presented in this paper that NO is unable to activate signaling proteins acting downstream or independent of Ras that are required for neuronal differentiation.

Zwarta obrobka wyrzynkow z obsluga jednoosobowa

70%

W K.

Biuletyn Informacyjny Ośrodka Badawczo-Rozwojowego Przemysłu Płyt Drewnopochodnych w Czarnej Wodzie

1994

tom 35

nr 3

196-198

Ograniczanie wyników

1 Biuletyn Informacyjny Ośrodka Badawczo-Rozwojowego Przemysłu Płyt Drewnopochodnych w Czarnej Wodzie

1 Cellular and Molecular Biology Letters

1 Teka Komisji Motoryzacji i Energetyki Rolnictwa

1 Barbakadze T.

1 Bator J.

1 Berta G.

1 Golubenko A.

1 Mikeladze D.

1 Osenin Y. Y.

1 Ramsden J.

1 Sosnov I.

1 Szeberenyi J.

1 Varga J.

1 W K.

1 2012

1 2011

1 1994

Wyniki wyszukiwania

Contour contact area of the block and disk of the disk brake under the conditions of thermal deformations

Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein

Zwarta obrobka wyrzynkow z obsluga jednoosobowa