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The aim of the study was to examine the efficacy of Tofline in prophylaxis of MMA syndrome in sows and to determine the influence of the preparation on production effects. Experiments were performed in 2 farms with similar natural environment conditions. 60 sows and their 625 piglets were used in the study. In each farm randomly chosen animals were divided into 2 groups: experimental and control. There were 20 sows on farm A and 10 sows in farm B in each group. Each sow in the experimental group after parturition was injected intramuscularly with Tofline at a dose of 1 ml/20 kg of body weight. Sows from the control groups were not injected with any drugs. MMA syndrome was detected in a total of 7 sows (23.33%) in the experimental groups of both farms, whereas in 8 sows (26.66%) were infected in the control groups. Additionally, the sows were treated with commercially available antibiotics: Combi-Ject (Dopharma BV), Pen-Strep (Norbrook) or Oxyvet (Polfa) in doses recommended by the producers. Sows were treated with oxytocin in a dose 20-30 i.u. and Tofline at a dose of 1 ml/20 kg of body weight. The therapeutic effect after the first treatment was observed in 9 sows (60%). In 6 (40%) cases out of 15 the treatment was repeated, while in 2 cases the antibiotic was changed until a therapeutic effect was observed. Body weight and number of piglets at the day of birth was similar in all the examined groups. However, at the end of the trail, the beneficial production effects in piglets from sows of experimental groups concerning daily weight gain were statistically significant (p  0,05). In groups of piglets administered with Tolfine clinical signs of diarrhea were observed in 9 litters (30%), while in control groups 14 litters (46.66%) were affected. Fertility and culling rate also increased after administering Tolfine. A total of 90% of sows were successfully inseminated in the experimental groups, whereas in the control groups the total was 83.34%.
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