Wyniki wyszukiwania

1

Some behavioural effects of carbamazepine - comparison with haloperidol

100%

Nowakowska E., Kus K., Czubak A., Glowacka D., Matschay A.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 2

The experiments presented in this paper aimed to investigate the influence of atypical antiepileptic drug carbamazepine (CBZ, CAS 298-46-4) classified also as normothymic drug on spatial memory in Morris water maze test and anxiolytic effect in two-compartment exploratory test in rats. The study also investigated the probably occurring side effects (measuring cataleptic activity and motor coordination) following single and chronic administration of CBZ compared to haloperidol (HAL, CAS 52-86-8), a conventional antipsychotic. All the tests were carried out on male Wistar rats. CBZ 30 mg/kg was administered orally 60 min before the tests and HAL 0.15 mg/kg was administered orally 60 min before the tests. In the Morris test memory improvement only after chronic administration of CBZ on the 7 and 14 day of treatment was observed, whereas after 14 days of HAL treatment spatial memory impairment was noted. In the two-compartment exploratory test 30 mg/kg of CBZ had an anxiolytic effect after 7 and 14 days of treatment, whereas HAL did not show anxiolytic effect after single and chronic treatment. CBZ did not induce catalepsy after single as well as chronic administration. HAL evoked a strong cataleptic effect both after acute and chronic treatment. CBZ had no impact on motor coordination in the chimney test and HAL disturbed motor coordination in rats after single as well as chronic administration. CBZ may be an useful normothymic drug using in bipolar affective disorder treatment with co-occurred anxiety and cognitive deficits. The lack of significant side effects of CBZ may be an alternative way of treatment in comparison with older drugs, such as lithium carbonate.

2

Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats

100%

Filip M., Antkiewicz-Michaluk L., Zaniewska M., Frankowska M., Golda A., Vetulani J., Przegalinski E.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 4

The efficacy of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), a member of endogenous tetrahydroisoquinolines, in cocaine- and food-maintained responding in self-administration procedures under a fixed ratio 5 schedule of reinforcement as well as in cocaine and food seeking behaviors in male Wistar rats was examined. The effects of 1MeTIQ on cocaine discrimination and on basal locomotor activity were also assessed. In rats trained to self-administered either cocaine (0.5 mg/kg/injection) paired with the cue (light+tone) or food under a fixed ratio 5 schedule of reinforcement, 1MeTIQ (25 - 50 mg/kg) dose-dependently decreased the cocaine-maintained responding, but did not alter the food-maintained responding. 1MeTIQ (25 - 50 mg/kg) decreased the cocaine seeking behavior reinstated by a noncontingent presentation of cocaine (10 mg/kg, i.p.), but altered neither behavior reinstated by a discrete cue (tone+light) nor food-induced reinstatement. In rats trained to discriminate cocaine (10 mg/kg) from saline in water-reinforced fixed ratio 20 task, pretreatment with 1MeTIQ resulted in neither substitution nor significant alterations in the cocaine (1.25 - 10 mg/kg)-induced discriminative stimulus effects. 1MeTIQ (25 - 50 mg/kg) did not produce also a significant changes in basal horizontal activity. In conclusion, our present results outline a significance of exogenously applied 1MeTIQ in attenuating drug-evoked relapses to cocaine as well as the direct rewarding properties of cocaine (that model the cocaine-induced "high"), but not cocaine subjective effects. Moreover, a dissociation between effects of 1MeTIQ on cocaine vs. food-maintained responding was demonstrated.

3

Intraperitoneal zinc administration increases extracellular zinc in the rat prefrontal cortex

84%

Opoka W., Sowa-Kucma M., Kowalska M., Bas B., Golembiowska K., Nowak G.

Journal of Physiology and Pharmacology

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2008

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tom 59

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nr 3

477-487

Single administration of zinc evokes pharmacological behavioral effects in rodents, while no brain zinc alterations were detected. The aim of the present study was to examine the effect of a single zinc hydroaspartate intraperitoneal (ip) administration on the extracellular (synaptic) zinc concentration in the rat prefrontal cortex. We used anodic stripping voltammetric (ASV) method of zinc determination in microdialysate, which assays the extracellular zinc concentration. We report that acute (65 mg/kg) zinc hydroaspartate administration (ip) increases the extracellular zinc by 48% in the rat prefrontal cortex. These data for the first time demonstrate: 1) utility of ASV zinc detection in brain microdialysates and 2) that single ip zinc administration increases brain (cortical) extracellular zinc pool. The results indicate zinc-induced fast brain penetration and may explain its rapid pharmacological effects.

4

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Behavioural effects of luteinizing hormone-releasing hormone [LHRH] in rats

84%

Mrowiec J., Plech A., Rzeszotarska B., Ryszka F., Brus R., Masiukiewicz E.

Journal of Physiology and Pharmacology

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1992

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tom 43

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nr 3

Behavioural effects of intracerebroventricularly-injected (icv) LHRH were studied in female rats. Locomotor and exploratory activities as well as irritability were determined. A pronounced inhibitory effect of 10µg doses of LHRH was found. At 100/µg doses of LHRH, barrel behaviour was observed. We conclude that LHRH can modify the activity of central serotonergic receptors in rats.

5

The effect of naloxone on object exploration, object recognition and other types of spontaneous behavior

84%

Lukaszewska I., Klepaczewska A.

Acta Neurobiologiae Experimentalis

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1997

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tom 57

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nr 2

6

Behavioral, morphological and histopathological effects of sublethal doses of quercetin on the species Polycelis felina (Dalyell)

67%

Rejevic N., Matkovic H., Gregorovic G., Kovacevic G., Knezovic L., Kalafatic M.

Folia Biologica

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2013

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tom 61

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nr 1-2

7

A comparison of febrile responses induced by LPS from E.coli and S.abortus in unrestrained rats placed in a thermal gradient

67%

Bodurka M., Caputa M., Bodurka J.

Journal of Physiology and Pharmacology

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1997

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tom 48

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nr 1

8

Behavioural effects of insect neuropeptide leucopyrokinin [LPK] in rats

67%

Rykaczewska-Czerwinska M.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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2002

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tom 50

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nr 2

9

Behavioural effects of [2-8]-leucopyrokinin [[2-8]-LPK], an active, synthetic analogue of insect neuropeptide leucopyrokinin [LPK] in rats

67%

Rykaczewska-Czerwinska M., Konopinska D., Plech A.

Pestycydy

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2004

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nr 3-4

Ograniczanie wyników

Some behavioural effects of carbamazepine - comparison with haloperidol

Effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the behavioral effects of cocaine in rats

Intraperitoneal zinc administration increases extracellular zinc in the rat prefrontal cortex

Behavioural effects of luteinizing hormone-releasing hormone [LHRH] in rats

The effect of naloxone on object exploration, object recognition and other types of spontaneous behavior

Behavioral, morphological and histopathological effects of sublethal doses of quercetin on the species Polycelis felina (Dalyell)

A comparison of febrile responses induced by LPS from E.coli and S.abortus in unrestrained rats placed in a thermal gradient

Behavioural effects of insect neuropeptide leucopyrokinin [LPK] in rats

Behavioural effects of [2-8]-leucopyrokinin [[2-8]-LPK], an active, synthetic analogue of insect neuropeptide leucopyrokinin [LPK] in rats