Hemorrhagic diathesis in neonatal calves is a new and emerging disease of young calves. The disease affects calves aged less than 4 weeks. Clinical signs in calves include skin and intestinal bleeding as well as petechiae on all mucosal membranes. The cause of this syndrome is as of yet unknown. In this study, to the best of our knowledge, the authors demonstrated the first case of hemorrhagic diathesis in neonatal calves with hematological and histopathological diagnosis. Clinical examinations demonstrated cutaneous bleeding. Hematological examination showed thrombocytopenia (43.7 × 10⁹/L) and pancytopenia (1.47 × 10⁹/L). During necropsy multiple generalized petechiae, ecchymoses or hemorrhages were ascertained. Histopathology revealed a multifocal extravasation of red blood cells (hemorrhage). Severe loss of hematopoietic tissue of the bone marrow was the most prominent finding on histology. The BVD antigen test was negative.
This case report describes a 3-year-old male guinea pig with malignant lymphoma (lymphosarcoma). Clinical examination revealed apathy, dyspnoea, weight loss, bilateral swelling of conjunctiva and lymphadenomegaly. Periphery blood examination revealed leukocythosis with lymphocythosis. Radiological and ultrasound examination showed free fluid in the thoracic cavity, hepatomegaly, splenomegaly and the enlargement of mesenteric lymph nodes. Cytological examination by fine needle aspirate from the mandibular lymph node revealed a pleomorphic population of medium to large lymphoblastic cells. Macroscopical examination revealed a generalized enlargement of periphery and mesenteric lymph nodes, infiltrates in pleura pulmonalis, free fluid in thoracic cavity, hepatomegaly and splenomegaly. Histological examination showed lymphoblastic infiltrates in almost all organs, especially liver, spleen, lungs and bone marrow.