Wyniki wyszukiwania

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Ultrastructural alterations of endothelium covering advanced atherosclerotic plaque in human carotid artery visualised by scanning electron microscope

100%

Walski M., Chlopicki S., Celary-Walska R., Frontczak-Baniewicz M.

Journal of Physiology and Pharmacology

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2002

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tom 53

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nr 4,1

Human atherosclerotic plaque morphology at its various stages was extensively documented using light microscopy. However, much less is known of the ultrastructure of the human atherosclerotic plaque, in particular of ultrastructure of endothelial cells in atherosclerosis. Here, we analysed alterations of endothelial cells covering advanced atherosclerotic plaque in carotid artery using scanning electron microscope. Examination was performed on specimens from atherosclerotic lesions of the interior carotid artery, collected from 8 patients who had undergone endarterectomy. We found wide spectrum of pathological alterations of the luminal surface of atherosclerotic plaque. In dominant part of the vessel, endothelial layer was preserved but displayed pronounced irregularities in endothelial architecture including appearance of cuboidal cells. Some endothelial cells were covered by numerous microvilli and/or contained "craters" disrupting continuous surface of the endothelium. Platelets and leukocytes adhering to endothelium were frequently observed. There were also areas of the vessel lumen with endothelial denudation, in which the subendothelial surface containing fibrin proteins and collagen fibrils were visible. Interestingly, signs of proliferation of endothelial cells tending to cover the partially denuded vessel were observed. In summary, in scanning electron microscope, preserved endothelial cells of advanced atherosclerotic plaque displayed pronounced pathology; whether any of these changes represent the ultrastructural correlate of endothelial dysfunction remains to be established.

2

The antiatherogenic effect of new biocompatible cationically modified polysaccharides: chitosan and pullulan - the comparison study

84%

Stefan J., Kus K., Wisniewska A., Lorkowska-Zawicka B., Kaminski K., Szczubialka K., Nowakowska M., Korbut R.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 6

3

New cationically modified pullulan attenuates atherogenesis and influences lipid metabolism in apoE-knockout mice

84%

Stefan J., Kus K., Wisniewska A., Kaminski K., Szczubialka K., Jawien J., Nowakowska M., Korbut R.

Journal of Physiology and Pharmacology

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2016

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tom 67

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nr 5

4

Effect of nebivolol treatment on atherosclerotic plaque components in apoE-knockout mice

84%

Pyka-Fosciak G., Jawien J., Gajda M., Jasek E., Litwin J. A.

Journal of Physiology and Pharmacology

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2013

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tom 64

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nr 6

5

Potentially positive ageing-related variations of medial smooth muscle cells in the saphenous veins used as aortocoronary bypass grafts

84%

Perek B., Malinska A., Gasowski J., Ostalska-Nowicka D., Perek A., Jemielity M., Zabel M., Nowicki M.

Folia Histochemica et Cytobiologica

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2016

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tom 54

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nr 2

6

Triple immunofluorescence labeling of atherosclerotic plaque components in apoE-LDLR mice

67%

Gajda M., Jawien J., Mateuszuk L., Lis G. J., Radziszewski A., Chlopicki S., Litwin J. A.

Folia Histochemica et Cytobiologica

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2008

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tom 46

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nr 2

143-146

7

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Oxidized low density lipoprotein inhibits inducible nitric oxide synthase, GTP cyclohydrolase I and transforming growth factor beta gene expression in rat macrophages

67%

Dulak J., Polus M., Guevara I., Hartwich J., Wybranska I., Krzesz R., Dembinska-Kiec A.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 3

8

Izomery kwasow oleinowego i linolowego jako skladniki blaszki miazdzycowej

51%

Stachowska E., Dolegowska B., Chlubek D., Bober J., Gutowski P., Cnotliwy M., Trojnacka B.

Bromatologia i Chemia Toksykologiczna

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2002

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tom 35

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nr 1

87-91

Zbadano zawartość izomerów trans kwasu oleinowego (C18:1), izomerów trans 9, trans 12 kwasu hnolowego (C18:2) oraz sprzęgniętych dienów kwasu linolowego (CLA) w blaszkach miażdżycowych tętnicy szyjnej pozyskanych śródoperacyjnie od pacjentów operowanych z powodu powikłań miażdżycy. Przeprowadzono analizę chromatograficzną 17 blaszek, stwierdzając w większości z nich obecność izomerów trans kwasu oleinowego i izomerów trans 9, trans 12 kwasu linolowego.

Ograniczanie wyników

Ultrastructural alterations of endothelium covering advanced atherosclerotic plaque in human carotid artery visualised by scanning electron microscope

The antiatherogenic effect of new biocompatible cationically modified polysaccharides: chitosan and pullulan - the comparison study

New cationically modified pullulan attenuates atherogenesis and influences lipid metabolism in apoE-knockout mice

Effect of nebivolol treatment on atherosclerotic plaque components in apoE-knockout mice

Potentially positive ageing-related variations of medial smooth muscle cells in the saphenous veins used as aortocoronary bypass grafts

Triple immunofluorescence labeling of atherosclerotic plaque components in apoE-LDLR mice

Oxidized low density lipoprotein inhibits inducible nitric oxide synthase, GTP cyclohydrolase I and transforming growth factor beta gene expression in rat macrophages

Izomery kwasow oleinowego i linolowego jako skladniki blaszki miazdzycowej