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  1. 5 Archivum Immunologiae et Therapiae Experimentalis

  2. 4 Journal of Physiology and Pharmacology

  3. 2 Acta Biochimica Polonica

  4. 2 Cellular and Molecular Biology Letters

  5. 1 Annals of Agricultural and Environmental Medicine

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  1. 2 Bauerova K.

  2. 2 Mascia C.

  3. 2 Mihalova D.

  4. 2 Ponist S.

  5. 1 Amagase K.

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  1. 1 2018

  2. 1 2017

  3. 1 2013

  4. 3 2012

  5. 2 2011

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1

Long-circulating liposomes for I.V. targeted delivery of glucocorticoids in arthritis

100%
Metselaar J. M., Wauben M. H. M., Boerman O. C., Van Lent P. L., Storm G.
Cellular and Molecular Biology Letters
|
2002
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tom 07
|
nr 2
2

Hip and knee arthritis in dairy farmers

86%
May J., Keene C., Bauer M., Dalal R., Groff G., Reis M.
Annals of Agricultural and Environmental Medicine
|
1994
|
tom 01
|
nr 2
3
Content available remote

Role of endothelial nitric oxide synthase in aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats

72%
Kato S., Ohkawa F., Ito Y., Amagase K., Takeuchi K.
Journal of Physiology and Pharmacology
|
2009
|
tom 60
|
nr 4
147-155
The role of nitric oxide synthase (NOS) isozymes in the aggravation of indomethacin-induced gastric damage in adjuvant arthritic rats was investigated. Two weeks after injection of Freund’s complete adjuvant, the animals were given indomethacin, and the stomach was examined for damage 4 h later. Indomethacin caused hemorrhagic lesions in the normal rat stomach, and these lesions were markedly aggravated in arthritic rats. Pretreatment with L-NAME (a nonselective inhibitor of NOS) and aminoguanidine (a relative selective inhibitor of iNOS) did not affect the ulcerogenic response in normal rats but dose-dependently prevented the aggravation of lesions in arthritic rats, but the effect of aminoguanidine was apparently less than that of L-NAME. The increased ulcerogenic response in arthritic rats was significantly suppressed by 1400 W (a selective inhibitor of iNOS) and L-NIO (a selective inhibitor of eNOS) but not by L-NPA (a selective inhibitor of nNOS). The concurrent administration of 1400 W and L-NIO almost totally abolished the aggravation of damage in arthritic rats. The expressions of eNOS and iNOS but not nNOS in the gastric mucosa were clearly enhanced in arthritic rats. Mucosal levels of non-protein sulfhydryls were significantly lower in arthritic rats than those in normal rats. The aggravation of damage in arthritic rats was significantly prevented by glutathione. These results suggest that the increased ulcerogenic response to indomethacin in arthritic rat stomachs is mediated by NO derived from eNOS in addition to iNOS. It is assumed that eNOS/NO may act harmfully on the gastric mucosa of arthritic rats with mucosal SH deficiency.
4
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Lyme borreliosis

72%
Szulzyk T., Flisiak R.
Annals of Parasitology
|
2012
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tom 58
|
nr 2
Lyme borreliosis is an infectious disease caused by spirochaetal bacteria, Borrelia burgdorferi sensu lato, which is transmitted by Ixodes spp. ticks. Several of Borrelia burgdorferi genospecies are pathogenic to humans. Endemic areas of the disease in Europe include: Scandinavia, Eastern Europe, Austria, Germany, Slovenia. In Poland the number of reported cases has increased since 1996 and large majority of all cases are diagnosed in Podlasie and Warmia-Mazuria provinces. The earliest symptom of Lyme borreliosis is characteristic skin rash, erythema migrans. If untreated, it can affect the nervous system, joints and the heart. Initial diagnosis of Lyme borreliosis is based on symptoms, physical findings, and the history of a tick-bite. Centers for Disease Control recommended two-step laboratory testing. The first step is immunoserological testing with enzyme immunoassay (EIA) for the presence of specific antibodies. Only in case of positive or equivocal EIA, the second step with western blot technique should be carried out. Other diagnostic methods are not recommended. In early stages of the disease patients should receive oral antibiotics, e.g. amoxicillin, doxycycline or cefuroxime axetil, with treatment lasting 14–21 days. In some cases (neuroborreliosis, carditis and chronic arthritis) patients require intravenous treatment usually with ceftriaxone or penicillin for 14–28 days. Superiority of longer therapy with higher doses of antibiotics, combination treatment with two or more antibiotics, or sequence therapy is not supported by any results of clinical trials, therefore it should not be applied and recommended according to the principles of evidence based medicine.
5
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Central single and chronic administration of morphine stimulates corticosterone and interleukin 9(IL)-6 in adjuvant-induced arthritis

72%
Zubelewicz B., Muc-Wierzgon M., Harbuz M. S., Brodziak A.
Journal of Physiology and Pharmacology
|
2000
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tom 51
|
nr 4,2
6

The complexities of CD28 and CTLA-4 signalling: PI3K and beyond

72%
Ward S. G.
Archivum Immunologiae et Therapiae Experimentalis
|
1999
|
tom 47
|
nr 2
7

Combined methotrexate and coenzyme Q10 therapy in adjuvant-induced arthritis evaluated using parameters of inflammation and oxidative stress

58%
Bauerova K., Paulovicova E., Mihalova D., Drafi F., Strosova M., Mascia C., Biasi F., Rovensky J., Kucharska J., Gvozdjakova A., Ponist S.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 3
Rheumatoid arthritis is a common severe joint disease that affects all age groups, it is thus of great importance to develop new strategies for its treatment. The aim of the present study was to examine the combined effect of coenzyme Q10 (CoQ10) and methotrexate (MTX) on the progression of adjuvant-induced arthritis in rats. Adjuvant arthritis (AA) was induced by a single intradermal injection of heat-inactivated Mycobacterium butyricum in incomplete Freund's adjuvant. The experiments included healthy animals, arthritic animals not treated, arthritic animals treated with CoQ10, with methotrexate, and with a combination of CoQ10 and methotrexate. The two latter groups received a daily oral dose of 20 mg/kg b.w. of CoQ10, either alone or with methotrexate in an oral dose of 0.3 mg/kg b.w. twice a week. We found that CoQ10 potentiated both the antiarthritic (decrease of hind paw volume) and the antioxidant effect of methotrexate on the level of oxidation of proteins (suppression of protein carbonyl level in plasma) as well as lipoperoxidation (suppression of levels of HNE-adducts and MDA-adducts to plasma proteins). The same effect was observed for plasmatic levels of CoQ9 and IL-1α, and partially also for γ-glutamyltransferase activity assessed in joints and spleen. Moreover, the combination therapy improved the functionality of peripheral blood neutrophils in AA, with a balancing effect on the immunosuppression caused by MTX monotherapy. In summary, combined administration of CoQ10 and methotrexate suppressed arthritic progression in rats more effectively than did MTX alone. This finding may help improve treatment of rheumatoid arthritis.
8
Content available remote

Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue stomach from NSAID damage

58%
Park S. H., Hong H., Han Y. M., Kangwan N., Kim S. J., Kim E. H., Hahm K. B.
Journal of Physiology and Pharmacology
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2013
|
tom 64
|
nr 2
9

Autoimmunity caused by T cells escaping negative selection

58%
Rolink A.
Archivum Immunologiae et Therapiae Experimentalis
|
2011
|
tom 59
|
nr 5
10

Lactobacillus rhamnosus exopolysaccharide ameliorates arthritis induced by the systemic injection of collagen and lipopolysaccharide in DBA/1 mice

58%
Nowak B., Ciszek-Lenda M., Srottek M., Gamian A., Kontny E., Gorska-Fraczek S., Marcinkiewicz J.
Archivum Immunologiae et Therapiae Experimentalis
|
2012
|
tom 60
|
nr 3
11
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Content available

Septic arthritis in adult horses

58%
Carstanjen B., Boehart S., Cislakova M.
Polish Journal of Veterinary Sciences
|
2010
|
tom 13
|
nr 1
201-212
Septic arthritis in horses is a serious disease which can become life-threatening. In case the infection can be eliminated before irreversible joint damage occurs, complete recovery is possible. This article gives an overview of the literature concerning etiology, diagnosis and strategies of therapy in cases of septic arthritis in adult horses, with special reference to novel options of treatment.
12
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Content available

Borage (Borago officinalis L.) - a valuable medicinal plant used in herbal medicine

58%
Pieszak M., Mikolajczak P. L., Manikowska K.
Herba Polonica
|
2012
|
tom 58
|
nr 4
In Europe, the use of herbs in the treatment of various ailments had been natural for centuries. Nowadays, phytotherapy is a way to support typical pharmacotherapy of many diseases. Borage (Borago officinalis L.) is one out of more than 20 000 plants of therapeutic properties. The results of some studies indicate that Borago officinalis L. is commonly used adjunctively in disorders of the respiratory system, urinary tract, arthritis and skin problems. Biologically active compounds found in borage oil are used as additives in the treatment of atherosclerosis, as well as in the regulation of certain metabolic processes.
13

Identification of dendritic cells in the blood and synovial fluid of children with juvenile idiopathic arthritis

58%
Tabarkiewicz J., Postepski J., Olesinska E., Rolinski J., Tuszkiewicz-Misztal E.
Folia Histochemica et Cytobiologica
|
2011
|
tom 49
|
nr 1
14
Content available remote

Melanocortin-4 receptor agonist (RO27-3225) ameliorates soleus but not gastrocnemius atrophy in arthritic rats

58%
Gomez-SanMiguel A. B., Nieto-Bona M. P., Fernandez-Galaz C., Priego T., Martin A. I., Lopez-Calderon A.
Journal of Physiology and Pharmacology
|
2017
|
tom 68
|
nr 2
15

Correction of the abnormal ratio of OKT4plus to OKT8plus peripheral blood lymphocytes in patients suffering from juvenile arthritis (JCA) by the extract from calf thymuses

58%
Podwysocka M., Wieczorek Z., Zimecki M., Prusek W., Wieczorek E., Spiegel K.
Archivum Immunologiae et Therapiae Experimentalis
|
1989
|
tom 37
|
nr 1-2
16

Developing kinase for tools for drug discovery

58%
Davies S., Paterson A., Morr J., Ewen B., Armstrong C., Dale S.
Cellular and Molecular Biology Letters
|
2003
|
tom 08
|
nr 2A
17

Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system

58%
Hauff K., Zamzow C., Law W. J., De Melo J., Kennedy K., Los M.
Archivum Immunologiae et Therapiae Experimentalis
|
2005
|
tom 53
|
nr 4
18
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Characteristics of Polish avian reovirus strains

58%
Czekaj H., Samorek-Salamonowicz E., Kozdrun W.
Bulletin of the Veterinary Institute in Puławy
|
1998
|
tom 42
|
nr 2
This work aims to identify 6 virus field isolates, serologically determined as reoviruses. The type of cytopathic effect in cell cultures, physico-chemical properties and antigenic relationship were examined. The strains examined multiplied in CEF and CEK cultures, produced cytopathic effects and plaques, contained RNA in their genome, had no lipid envelope, were stable in an acid environment and belonged to the same serotype but two different subtypes.
19

Ból stawów - zastosowanie kwasu hialuronowego w przypadkach stanów zapalnych u koni

51%
Kane E.
Weterynaria po Dyplomie
|
2018
|
tom 19
|
nr 1
20

Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl

44%
Ponist S., Mihalova D., Jancinova V., Snir V., Ondrejickova O., Mascia C., Poli G., Stancikova M., Nosal R., Bauerova K.
Acta Biochimica Polonica
|
2010
|
tom 57
|
nr 2
The aim of this study was to evaluate the therapeutic potential of oxidative stress (OS) reduction by using pyridoindole (PI) antioxidants in adjuvant arthritis (AA). The substances tested were stobadine dipalmitate (STB) and SMe1. AA was used as animal model. The experiments included healthy animals, control arthritic animals and arthritic animals with administration of PI in the oral daily dose of 15 mg/kg b.m during 28 experimental days. The rats were sacrificed on day 28. Clinical and biochemical parameters were determined. The effect of PI administration was evaluated on the basis of the following parameters: (a) arthritis (volume of hind paws - HPW, change of animal body mass - CBM), (b) OS (chemiluminescence of whole blood - CWB, levels of thiobarbituric acid reacting substance - TBARS and of HNE- and MDA-protein adducts in plasma and activity of γ-glutamyltransferase (GGT) in hind paw joint homogenates). The PI studied significantly increased the CBM of animals and corrected the HPW. STB also significantly decreased the activity of GGT in joint homogenates. SMe1 was more effective in decreasing plasmatic TBARS levels, but STB was more effective in reducing plasmatic HNE- and MDA-protein adducts. The assay for HNE- and MDA-adducts in plasma as a function of time was applied for the first time in AA. STB markedly decreased spontaneous and PMA-stimulated CWB and reduced neutrophil count. In summary, STB was more effective than SMe1 in reducing OS in AA. Our results showed that the reduction of OS in arthritis also corrected the clinical manifestations of the disease.
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