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1

Role of NAD[P]H: quinone oxidoreductase [NQO1] in apoptosis induction by aziridinylbenzoquinones RH1 and MeDZQ

100%
Nemeikaite-Ceniene A., Dringeliene A., Sarlauskas J., Cenas N.
Acta Biochimica Polonica
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2005
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tom 52
|
nr 4
We aimed to characterize the role of NAD(P)H : quinone oxidoreductase (NQO1) in apoptosis induction by antitumour quinones RH1 (2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone) and MeDZQ (2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone). Digitonin-permeabilized FLK cells catalyzed NADPH-dependent single- and two-electron reduction of RH1 and MeDZQ. At equitoxic concentrations, RH1 and MeDZQ induced apoptosis more efficiently than the nonalkylating duroquinone or H2O2. The antioxidant N,N'-diphenyl-p-phenylene diamine, desferrioxamine, and the inhibitor of NQO1 dicumarol, protected against apoptosis induction by all compounds investigated, but to a different extent. The results of multiparameter regression analysis indicate that RH1 and MeDZQ most likely induce apoptosis via NQO1-linked formation of alkylating species but not via NQO1-linked redox cycling.
2

DNA damage and apoptosis induction in L1210 cells by cis-diamminedichloroplatinum [II] and its new aminoflavone analogue

84%
Ciesielska E., Studzian K., Zyner E., Ochocki J., Szmigiero L.
Cellular and Molecular Biology Letters
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2000
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tom 05
|
nr 4
441-450
This work compares the biological properties of cis-diammine- dichloroplatinum (cisplatin) and its new analogue cis-[Pt(AF)2Cl2] (AF stands for 3-aminoflavone), which contains two aminoflavone substituents as non-leaving ligands. Both compounds were tested for their antiproliferative activity against cultured L1210 cells, and their DNA interstrand crosslinking activity in cells and in a cell-free system. Cisplatin was found to be an approximately 6 times more cytotoxic drug than its new analogue. Platinum complexes reacted with purified calf thymus DNA in a cell-free system producing DNA interstrand crosslinks. The kinetics of crosslink formation was very similar for both compounds but the maximal level of crosslinks was 20% higher for cisplatin. In cells, however, crosslinks were produced by cisplatin, whereas this type of DNA lesion was almost undetected in cells treated with the aminoflavone analogue as assayed by DNA alkaline elution. At higher drug concentrations, strong degradation of DNA was observed in L1210 cells treated with cis- [Pt(AF)2Cl2] but not in the cells incubated with cisplatin. This DNA degradation seems to reflect very efficient apoptosis induction by cis-[Pt(AF)2Cl2] as the electrophoretic patterns of DNA from cells incubated with this drug showed a ladder typical for apoptotic cells.
3

Apoptosis induction of human peripheral blood lymphocytes by naturally occurring coumarins

84%
Kocki J., Bogucka-Kocka A.
Polish Journal of Environmental Studies
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2004
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tom 13
|
nr Suppl.2, Part 1
Our studies show the influence of coumarins: xanthotoxin and o,o-dimethyl-fraxetin on apoptosis in human peripheral blood lymphocytes in vitro. Lymphocytes (derived by ethical protocol) were cultured for 72 h in vivo. The cell cultures were stimulated with xanthotoxin or o,o-dimethyl-fraxetin in various concentrations. Apoptotic cells (compaction and margination of nuclear chromatin, cytoplasmic condensation, membrane blebbing and cell shrinkage) were observed in BX41 fluorescent Olympus microscope and recorded by MultiScan software. We observed the highest induction of apoptosis in cells stimulated with xanthotoxin in doses ≥50 μM in 48-hrs-cultures.
4

DNA damage and apoptosis induction in L1210 cells by cis-diamminedichloroplatinum[II] and its new aminoflavone analogue

84%
Ciesielska E., Studzian K., Zyner E., Ochocki J., Szmigiero L.
Cellular and Molecular Biology Letters
|
2000
|
tom 05
|
nr 2
5

Differential antitumor effect of essential oils and their major components of Thymus broussonettii: relationship to cell cycle and apoptosis induction

67%
Jaafari A., Ait Mouse H., Ait M'Bark L., Tilaoui M., Elhansali M., Lepoivre M., Aboufatima R., Melhaoui A., Chait A., Zyad A.
Herba Polonica
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2009
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tom 55
|
nr 2
36-50
Thymus broussonettii, a Moroccan endemic plant, exists in two chemotypes. The aim of our study is to compare the cytotoxic activity of their essential oils and major products as well as their effect on cell cycle and apoptosis induction. The chemical composition analysis of essential oils by GC-SM revealed that the lasts are rich and diverse and the major products of the chemotypes TbA and TbE are carvacrol and thymol, respectively. The in vitro cytotoxic effect study against five tumor cell lines shows that TbA essential oil, rich in carvacrol, has an important cytotoxic effect, higher than that of TbE, rich in thymol. This result is confirmed by comparing cytotoxic effect of carvacrol and thymol. Furthermore, TbA EO /carvacrol and TbE EO /thymol induce cell cycle arrest at S and G0/G1 phases, respectively. On the other hand, carvacrol, most cytotoxic in vitro, was studied for its effect on solid tumor in vivo and apoptosis-induction. Our results show that carvacrol, administred by gavage, has an important effect on solid tumor and induce apoptosis in P815 tumor cell line.
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