Wyniki wyszukiwania

1

Antithrombotic effect of L-arginine in hypertensive rats

100%

Cylwik D., Mogielnicki A., Kramkowski K., Stokowski J., Buczko W.

Journal of Physiology and Pharmacology

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2004

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tom 55

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nr 3

The aim of the study was to evaluate the effect of L-arginine (L-Arg) on haemostasis in stasis model of venous thrombosis in renal hypertensive rats. The effect of the single dose (i.v.300 mg/kg bolus+300 mg/kg/h) and of the 10-day application (p.o. 1 g/kg, once daily) of L-Arg was determined. L-Arg reduced the blood pressure both in the acute and long-term application. The single dose of L-Arg decreased the occurrence rate of the thrombus whereas long-term administration reduced significantly the thrombus weight. There were no differences in prothrombin time and activated partial thromboplastin time while the fibrinogen concentration decreased both in the acute and the long-term experiment. L-Arg shortened euglobulin clot lysis time and bleeding time in the long-term application. The chronic L-Arg treatment also inhibited significantly collagen-induced platelet aggregation. The overall haemostasis and coagulation potentials were inhibited and the fibrinolysis potential was higher in the group receiving this amino-acid. The results show that L-Arg, in a complex way, evokes the antithrombotic effect in the model of venous thrombosis in hypertensive rats.

2

Nitric oxide as a modulator in platelet- and endothelium-dependent antithrombotic effect of eplerenone in diabetic rats

84%

Gromotowicz-Poplawska A., Kloza M., Aleksiejczuk M., Marcinczyk N., Szemraj J., Kozlowska H., Chabielska E.

Journal of Physiology and Pharmacology

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2019

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tom 70

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nr 2

3

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Experimental studies on the anticoagulant and antithrombotic effects of sodium and calcium pentosan polysulphate

84%

Giedrojc J., Radziwon P., Klimiuk M., Bielawiec M., Breddin H. K., Kloczko J.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 1

4

The antithrombotic effect of captopril and losartan on experimental arterial thrombosis in rats

67%

Chabielska E., Pawlak R., Golatowski J., Buczko W.

Journal of Physiology and Pharmacology

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1998

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tom 49

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nr 2

5

The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade

67%

Buczko W., Matys T., Kucharewicz I., Chabielska E.

Journal of Physiology and Pharmacology

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1999

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tom 50

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nr 4

6

Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats

67%

Wojewodzka-Zelazniakowicz M., Chabielska E., Mogielnicki A., Kramkowski K., Karp A., Opadczuk A., Domaniewski T., Malinowska-Zaprzalka M., Buczko W.

Journal of Physiology and Pharmacology

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2006

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tom 57

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nr 2

This study compared the antihrombotic effect of plasma angiotensin converting enzyme inhibitors (ACE-Is): captopril (CAP), enalapril (ENA) and Tissue ACE-Is: perindopril (PER), quinapril (QUIN) in experimental venous and arterial thrombosis. Normotensive Wistar rats were treated p.o. with CAP (75 mg/kg), ENA (20 mg/kg), PER (2 mg/kg) and QUIN (3 mg/kg) for 10 days. The influence of ACE-Is on coagulation and fibrinolytic systems as well as platelet function was evaluated. The hypotensive effect of ACE-Is was equal in all groups. QUIN mantained the final carotid blood flow at the highest value in comparison to PER and plasma ACE-Is. The arterial thrombus weight was reduced in PER and QUIN groups while venous thrombus weight was also reduced after CAP. Tissue andplasma ACE-Is caused the inhibition of platelet adhesion and aggregation. A reduction of fibrin generation, prolongation of prothrombin time (PT), activated partial thromboplastin time (APTT) and shortening of euglobulin clot lysis time (ECLT) were observed after PER and QUIN treatment. In conclusion, given in equipotent hypotensive doses, Tissue ACE-Is exerted more pronounced antithrombotic effect than plasma ACE-Is in experimental thrombosis. The differences between Tissue and plasma ACE-Is in terms of their more pronounced inhibition of experimental thrombosis may be related to the intensified activation of fibrinolysis and inhibition of coagulation.

Ograniczanie wyników

Antithrombotic effect of L-arginine in hypertensive rats

Nitric oxide as a modulator in platelet- and endothelium-dependent antithrombotic effect of eplerenone in diabetic rats

Experimental studies on the anticoagulant and antithrombotic effects of sodium and calcium pentosan polysulphate

The antithrombotic effect of captopril and losartan on experimental arterial thrombosis in rats

The role of endothelium in antithrombotic effect of the renin-angiotensin system blockade

Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats