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  1. 8 Journal of Physiology and Pharmacology

  2. 4 Herba Polonica

  3. 2 Archivum Immunologiae et Therapiae Experimentalis

  4. 2 Folia Histochemica et Cytobiologica

  5. 1 Acta Scientiarum Polonorum. Hortorum Cultus

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  1. 2 Brzozowski T.

  2. 2 Fichna J.

  3. 2 Xu C.

  4. 1 Aboufatima R.

  5. 1 Adeboboye C. F.

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  1. 1 2023

  2. 4 2020

  3. 1 2019

  4. 2 2018

  5. 2 2017

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1
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Lichens as a source of chemical compounds with anti-inflammatory activity

100%
Studzinska-Sroka E., Dubino A.
Herba Polonica
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2018
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tom 64
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nr 1
Symptoms of inflammation accompany a number of diseases. In order to mitigate them, folk medicine has used a variety of medicinal substances, including herbs and mushrooms. Lichens are less known organisms, containing specific secondary metabolites with interesting biological properties. One of their biological actions is the anti-inflammatory activity that has been confirmed by in vitro and animal studies. It has been proven that compounds and extracts from lichens inhibit the enzymes involved in the inflammatory process. The following paper is a review of research on the little-known anti-inflammatory properties of lichens.
2
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants

100%
Strzelecka M., Bzowska M., Koziel J., Szuba B., Dubiel O., Rivera Nunez D., Heinrich M., Bereta J.
Journal of Physiology and Pharmacology. Supplement
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2005
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tom 56
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nr 1
139-156
It is believed that bioactive compounds from plant foods may have health beneficial effects and reduce the risk of chronic inflammatory diseases. In this study extracts of 121 plants typical for the traditional Mediterranean diet have been screened for their potential anti-inflammatory activities. The ability of the extracts to inhibit cytokinestimulated, iNOS-dependent synthesis of nitric oxide in murine endothelial cells, without affecting cell viability, was the primary indicator of their anti-inflammatory properties. Based on these experiments we selected eight plant extracts for further analysis: Chrysanthemum coronarium L., Scandix pecten-veneris L., Urospermum picroides (L.) Scop. Ex F. W. Smith, Amaranthus cf. graecizans L., Onopordum macracanthum Schousboe, Eryngium campestre L., Artemisia alba Turra and Merendera pyrenaica (Pourret) Fourn. Only the effects of Onopordum macracanthum could be non-specific since the extract strongly inhibited total protein synthesis. All remaining 7 extracts decreased nitric oxide and TNFa synthesis in the cells of monocyte origin activated with LPS, and 4 of them significantly reduced surface expression of VCAM1 on TNFa-stimulated endothelial cells. All seven plant extracts decreased cytokine or LPS-stimulated iNOS mRNA levels in both cell types. Further research to identify bioactive compounds influencing intracellular signaling pathways activated by cytokines and LPS will consequently be needed in order to better understand these in vitro effects.
3

Syntheses and properties of selected derivatives of pyrimido[5,4-e]-l,3-thiazine and pyrimido[4,5-d]pyrimidine

100%
Malinka W., Zawisza T., Zajac H. E.
Archivum Immunologiae et Therapiae Experimentalis
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1989
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tom 37
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nr 3-4
4
Content available remote

Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis

84%
Krajewska J. B., Pietruszka P., Tomczyk D., Chen C., Owczarek A., Karolewicz B., Czapor-Irzabek H., Gorniak A., Fichna J.
Journal of Physiology and Pharmacology
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2019
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tom 70
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nr 2
5
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
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Traditional Chinese herb, Astragalus: possible for treatment and prevention of COVID-19?

84%
Law S., Lo C., Han J., Leung A. W., Xu C.
Herba Polonica
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2020
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tom 66
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nr 4
6
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Micropropagation of Pluchea lanceolata (Oliver and Hiern.) using nodal explant

84%
Kher M. M., Joshi D., Nekkala S., Nataraj M., Raykundaliya D. P.
Journal of Horticultural Research
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2014
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tom 22
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nr 1
7
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Japanese quince (Chaenomeles japonica) leaf phenol extract as modulator of the inflammatory response in lipopolysaccharide-triggered murine macrophage RAW 264.7 cells

84%
Chojnacka K., Owczarek K., Caban M., Sosnowska D., Polka D., Koziolkiewicz M., Fichna J., Lewandowska U.
Journal of Physiology and Pharmacology
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2020
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tom 71
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nr 6
8
Content available remote

Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury

84%
Kim E. K., Cho J. H., Jeong A. R., Kim E. J., Park D. K., Kwon K. A., Chung J. W., Kim K. O., Kim J. H., Kim J. H., Kim Y. J.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 1
9
Content available remote

The central analgesic and anti-inflammatory activities of the methanolic extract of Carthamus oxycantha

84%
Bukhari I. A.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 3
10
Content available remote

Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves.

67%
Konturek P. C., Brzozowski T., Engel M., Burnat G., Gaca P., Kwiecien S., Pajdo R., Konturek S. J.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 2
41-47
Ghrelin is a novel growth hormone (GH)-releasing and orexigenic peptide with anti-inflammatory activities. However, the role of ghrelin in the colonic inflammation is still controversial. The aim of the present study was: 1) to examine the expression of ghrelin and TNF- mRNA in the inflamed colonic mucosa of patients with ulcerative colitis (UC), 2) to analyze the effect of treatment with exogenous ghrelin on the healing of trinitrobenze sulphonic acid (TNBS)-induced colitis in rats, and 3) to assess the effects of ghrelin treatment on mRNA expression for iNOS and protein expression for COX-2 and PPAR in intact colonic mucosa and in that with TNBS-induced colitis. Fifteen patients with UC and fifteen healthy controls were enrolled in this study. Expression of ghrelin and TNF- was assessed by semi-quantitative RT-PCR in the colonic mucosal biopsies from UC patients and healthy controls. In addition, the effect of exogenous ghrelin on healing of TNBS colitis was tested in rats without or with capsaicin-induced functional ablation of sensory nerves. Patients with UC showed a significant upregulation of mRNA for ghrelin and TNF- in colonic mucosa as compared to that observed in healthy controls. The expression of ghrelin correlated with the grade of inflammation and expression of TNF-. In rats the exogenous ghrelin administered daily at a dose of 20 µg/kg i.p. significantly accelerated the healing of TNBS colitis and this effect was accompanied by an increase in mRNA expression for iNOS and protein expression for COX-2 in the colonic mucosa. The protein expression for PPAR, which was down-regulated in rat colonic mucosa after exposure to TNBS as compared to that in intact colonic mucosa, was not significantly influenced by ghrelin treatment. We conclude that 1) patients with UC show an increased mucosal expression of mRNA for ghrelin in the colonic mucosa which could trigger protective response in inflamed colon; and 2) exogenous ghrelin accelerates healing of colonic lesions in animal model of ulcerative colitis via increased release of NO and PGE2 due to an increase in iNOS and COX-2 expression and stimulation of sensory neuropeptides such as CGRP released from sensory afferent endings.
11
Content available remote

Modulation of inflammatory response by pentoxifylline is independent of heme oxygenase-1 pathway

67%
Taha H., Grochot-Przeczek A., Was H., Kotlinowski J., Kozakowska M., Marek A., Skrzypek K., Lackowska B., Balcerczyk A., Mustafa S., Dulak J., Jozkowicz A.
Journal of Physiology and Pharmacology
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2009
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tom 60
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nr 2
3-12
Objective: It was reported that some effects of pentoxifylline (PTX) are mediated by heme oxygenase-1 (HO-1) induction. We investigated the role of HO-1 in anti-inflammatory activity of PTX. Methods: Experiments were performed in human and murine monocytes and endothelial cells and in HO-1 deficient mice. Results: PTX dose-dependently decreased expression of HO-1 in cell lines studied. As expected, PTX reduced also production of TNF. This effect was independent of HO-1 activity, as demonstrated in cells treated with HO-1 activators and inhibitors or in cells overexpressing HO-1. Moreover, inhibition of TNF was the same in human endothelial cells of different HO-1 genotypes, showing that PTX is similarly efficient in carriers of more and less active HO-1 promoter variants. In mice, PTX did not influence HO-1 expression, as measured in liver, kidney, spleen, heart, and skin. Accordingly, the response of PTX treated animals to LPS was the same in wild type and HO-1 deficient mice. PTX to a similar extent increased influx of leukocyte into peritoneal cavity, decreased production of TNF and reduced expression of VCAM-1 in vascular intima. Conclusion: PTX inhibits production of TNF and may decrease inflammatory reaction both in vitro and in vivo, but these effects are independent of HO-1.
12
Content available remote

Myrtus communis improves cognitive impairment in renovascular hypertensive rats

67%
Cevikelli-Yakut Z.-A., Ertas B., Sen A., Koyuncuoglu T., Yegen B. C., Sener G.
Journal of Physiology and Pharmacology
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2020
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tom 71
|
nr 5
13

Bisdemethoxycurcumin exerts a cell-protective effect via JAK2/STAT3 signaling in a rotenone-induced Parkinson’s disease model in vitro

67%
He D., Chen S., Xiao Z., Wu H., Zhou G., Xu C., Chang Y., Li Y., Wang G., Xie M.
Folia Histochemica et Cytobiologica
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2020
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tom 58
|
nr 2
14

The anticancer activity of propolis

67%
Sawicka D., Car H., Borawska M. H., Niklinski J.
Folia Histochemica et Cytobiologica
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2012
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tom 50
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nr 1
15
Content available remote

New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity

67%
Mazur-Bialy A. I., Bilski J., Pochec E., Brzozowski T.
Journal of Physiology and Pharmacology
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2017
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tom 68
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nr 2
16

Anti-inflammatory, antipyretic and antioxidant activities of the earthworms extract

67%
Omar H. M., Ibraheim Z. Z., El-Shimy N. A., Ali R. S.
Journal of Biology and Earth Sciences
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2012
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tom 02
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nr 1
17
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Laetiporus sulphureus - chemical composition and medicinal value

67%
Sulkowska-Ziaja K., Muszynska B., Gawalska A., Salaciak K.
Acta Scientiarum Polonorum. Hortorum Cultus
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2018
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tom 17
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nr 1
The higher fungi are a rich source of chemical compounds with multi-directional therapeutic and pro-health effects. This review summarizes the results of the most important chemical and biological studies of the fruiting bodies and the mycelial cultures of Laetiporus sulphureus. Numerous studies have demonstrated the antimicrobial, anticancer, cytotoxic, hypoglycemic anti-inflammatory and antioxidant activity of the extracts. Currently, only a few wood-decay fungi have practical use in medicine. Therefore it seems important to continue research on the effectiveness and safety of extracts and compounds of natural origin, including fungi, whose potential is not still used.
18
Artykuł dostępny w postaci pełnego tekstu - kliknij by otworzyć plik
Content available

Cytokine-mediated immunoregulatory activity of Lactobacillus species in a carrageenan-induced acute inflammatory model

67%
Oladejo B. O., Adeboboye C. F., Adiji P. I., Adebolu T. T.
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
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2023
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tom 104
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nr 1
19

Terpenes: substances useful in human healthcare

67%
Paduch R., Kandefer-Szerszen M., Trytek M., Fiedurek J.
Archivum Immunologiae et Therapiae Experimentalis
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2007
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tom 55
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nr 5
20

Niektore aspekty leczniczego dzialania zielonej herbaty

59%
Calka J., Zasadowski A., Juranek J.
Bromatologia i Chemia Toksykologiczna
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2008
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tom 41
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nr 1
5-14
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