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Antidiabetic effects of Eucalyptus globulus on pancreatic islets: a stereological study

100%

Mahmoudzadeh-Sagheb H., Heidari Z., Bokaeian M., Moudi B.

Folia Morphologica

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2010

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tom 69

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nr 2

The leaves of Eucalyptus globulus (eucalyptus) are used for the treatment of diabetes mellitus in traditional medicine. The aim of this study was to evaluate the effects of eucalyptus on streptozotocin (STZ)-induced damage in pancreatic islands by stereological methods. Fifty mature normoglycaemic male Wistar rats, weighing 200–250 g, were selected and randomly divided into 5 groups (n = 10): control; STZ-induced diabetic (D) — by intraperitoneal injection of 60 mg/kg streptozotocin; treated control (TC); and treated diabetic (TD₁, ₂), respectively, received 20 and 62.5 g/kg of eucalyptus in their diet, and 2.5 g/L aqueous extract of eucalyptus in their drinking water from one week after induction of diabetes. After four weeks of the experiment, stereological estimation of volume density and total volume of islets and beta cells, volume-weighted mean islet volume, mass of the islets and pancreas, and total number of islets were carried out. Administration of eucalyptus significantly decreased the weight loss and increase of water and food intake in the treated diabetic groups in comparison to the STZ-induced diabetic (D) group. Volume density and total volume of islets, volume-weighted mean islet volume, mass of islets, and mass of pancreas of both treated diabetic groups were higher than the D group. In TD₂, these stereological parameters increased significantly compared to the D group (p < 0.001). Volume density and total volume of beta cells increased 21% and 65%, respectively, in the TD₂ group, but it was not statistically significant compared to the diabetic group (p > 0.05). The results suggested that Eucalyptus globulus with a dose-dependent manner ameliorates diabetic states by partial restoration of pancreatic beta cells and repair of STZ-induced damage in rats. This study suggests a beneficial effect of eucalyptus in the treatment of diabetes. (Folia Morphol 2010; 69, 2: 112–118)

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Trigonella foenum-graecum seeds in treatment of metabolic syndrome

84%

Kania-Dobrowolska M., Baraniak J.

Herba Polonica

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2020

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tom 66

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nr 3

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Molecular docking and prediction of ADME/drug-likeness properties of potentially active antidiabetic compounds isolated from aqueous-methanol extracts of Gymnema sylvestre and Combretum micranthum

84%

Ononamadu C. J., Ibrahim A.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2021

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tom 102

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nr 1

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Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia

84%

Thanh Tam N., Thien D. D., Sung T. V., Thi Hoang Anh N., Thuy T. T., Trung K. H., Xuan T. D., Khanh T. D.

International Letters of Natural Sciences

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2016

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tom 50

Ursolic acid with large amount (0.67% of dried plant weight) along with 7 compounds, namely as spatozoate (1), kaurenoic acid (2), ursonic acid (3), 3-hydroxy-11-ursen-28,13-olide (4), ursolic acid (5), vindoline (6) and mixture of β-sitosterol and stigmasterol were isolated from dichloromethane and ethyl acetate extracts which have shown anti-glucosidase activity of the whole plant of C.roseus. Some isolated compounds and their derivatives were also tested for anti-glucosidase and cytotoxicity.Ursolic acid was examined for hypoglycemic activity in alloxan-induced diabetic mice with dose of 200 and 300 mg/kg/day, respectively. The results have shown that the blood glucose level were reduced by 45.75% and 51.31% to compare with the control group. This study has confirmed that the main component of Vietnamese C. roseus has had significant anti-hyperglycemia activity.

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Effect of bergenin on the kidney of C57BL/6J mice with high fat-diet induced oxidative stress

84%

Sagadevan A., Ramalingam S.

International Letters of Natural Sciences

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2016

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tom 54

The present study evaluated the protective effect of bergenin on high fat diet (HFD) induced diabetic mice. C57BL/6J mice were segregated in two groups, one fed standard diet (NC) and the other fed HFD for 16 weeks. Mice were fed continuously with high fat diet for 16 weeks and subjected to intragastric administration of bergenin (10, 20 and 40 mg/kg body weight (BW)), metformin (25 mg/kg BW) 9 to 16 weeks. At the end of the treatment nephritic markers, lipid peroxidation product, antioxidant and histopathological examination were carried out to assess the efficacy of the treatment. HFD fed mice showed increased plasma glucose, insulin, altered nephritic markers, antioxidant and histopathological abnormalities. Oral Treatment with bergenin (40 mg/kg BW) showed near normalized levels of plasma glucose, lipid peroxidation product, antioxidants, improved insulin and reduced kidney damage. The effects of bergenin were comparable with standard drug, metformin. These data suggest that bergenin protect kidney from deleterious effect of glucose.

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Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials

84%

Ogunjinmi O. S., Oriyomi V. O., Olaogun R. A., Gbadegesin A. T.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2024

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tom 105

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nr 1

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Antidiabetic and antiplatelet aggregation study of various methanol fractions of Nymphaea stellata Willd. leaves

67%

Raja M. M., Mishra S. H., Tamboli R. S., Agilandeswari D.

Herba Polonica

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2017

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tom 63

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nr 3

Introduction: Nymphaea stellata Willd. (Nymphaeaceae) is traditionally used for the treatment of diabetes. Alcohol extract of N. stellata leaves has been reported for hypoglycaemic activity. Objective: The aim of this study was to further investigate the different methanol fractions of N. stellata leaves for anti-diabetic activity and anti-platelet aggregation activity. Methods: Methanol extract was fractioned in to unsaponified petroleum ether fraction of methanol extract (UPFME), chloroform fraction of methanol extract (CFME) and residual fraction of methanol extract (RFME). All fractions were evaluated for in vivo anti-diabetic activity (STZ-NAD-induced rat model), in vitro anti-diabetic activity (PTP1B inhibition study) and anti-platelet aggregation activity. Results: UPFME showed significant changes in all studied parameters, compared to the diabetic control. UPFME also showed an IC50 value of 19.30±1.1 mg/ml and 13.11±0.7 μg/ml in PTP1B inhibition study and anti-platelet aggregation study, respectively. Conclusion: The study indicates that UPFME of N. stellata leaves exhibit anti-diabetic and anti-platelet aggregation activity.

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Phytochemical and pharmacological investigations on mangiferin

51%

Singh S. K., Sharma V. K., Kumar Y., Kumar S. S., Sinha S. K.

Herba Polonica

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2009

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tom 55

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nr 1

126-139

Mangiferin, a C-glucopyranoside of 1, 3, 6, 7-tetrahydroxyxanthone, has been isolated from various parts of Mangifera indica (Anacardiaceae). The conclusive structure of mangiferin has been established by various researchers using a wide range of chemical and spectral analytical techniques. Mangiferin has been traditionally used in some parts of world as anti-inflammatory, analgesic, antipyretic, antioxidant, immunomodulator, antitumor, antiviral, and anthelminthic and in obesity treatment. The present article is an attempt to encompass various aspects and details related to the characterization of mangiferin and its subsequent pharmacological screening. The literature data on mangiferin has been comprehensively reviewed and evaluated by the authors and hence, the article contains brief description of phytochemical and pharmacological investigations conducted on mangiferin till now and thus may prove as a guiding force for further research in this particular area.

Ograniczanie wyników

Antidiabetic effects of Eucalyptus globulus on pancreatic islets: a stereological study

Trigonella foenum-graecum seeds in treatment of metabolic syndrome

Molecular docking and prediction of ADME/drug-likeness properties of potentially active antidiabetic compounds isolated from aqueous-methanol extracts of Gymnema sylvestre and Combretum micranthum

Evaluation of ursolic acid as the main component isolated from Catharanthus roseus against hyperglycemia

Effect of bergenin on the kidney of C57BL/6J mice with high fat-diet induced oxidative stress

Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials

Antidiabetic and antiplatelet aggregation study of various methanol fractions of Nymphaea stellata Willd. leaves

Phytochemical and pharmacological investigations on mangiferin