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Immunomodulating and anticancer properties of fungi

100%

Kopczynski K.

Acta Mycologica

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2012

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tom 47

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nr 1

Fungi contain a number of biologically active substances whose importance for human health has been confirmed in several studies. In particular, β-glucans, selenium, vitamin D, C and E should be mentioned. These substances play an important role in shaping the immune system and prevent cancer. β-Glucans reduce the risk of cardiovascular disease and lower the cholesterol level.

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In vitro anti-cancer properties of natural vs synthetic conjugated linoleic acid

100%

Lipkowski A. W., Walisiewicz-Niedbalska W., Patkowska-Sokola B., Opolski A., Bodkowski R., Wietrzyk J., Pelczynska M., Nasulewicz A., Gwardiak H., Kwiatkowski J.

Animal Science Papers and Reports

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2003

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tom 21

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nr 1

Anti-proliferative activity was investigated of C18:2 9cis,11trans (conjugated linoleic acid – CLA) isomer isolated from sheep milk fat. The research was conducted on sheep milk fatty acids in natural composition (FA-1) containing 2.0% of the C18:2 9cis,11trans CLA isomer and preparation enriched with CLA, containing up to 9.2% of the CLA isomer (FA-2). The process of enrichment of FA-1 was carried out in two steps. Step I was to remove mid-chain-length saturated fatty acids, primarily C16,by forming adducts with urea (to obtain FA-U), while in step II the short-chain acids were removed by way of supercritical extraction with CO2. The final preparation obtained (FA-2) contained 9.2% of the C18:2 9cis,11trans isomer. A natural sheep milk fatty acid composition (FA-1), the CLA-enriched product (FA-2) and a commercial CLA preparation (CP) were tested for anti-proliferative activity against the cells of human cervical carcinoma (KB), and leukaemia (HL-60). The ID50 dose (resulting in a 50% inhibition of cell proliferation) of FA-2 was found lower than that of the CP preparation. The SRB test showed.

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Biochanin A similarly influences the fluidity of liposomes formed from charget and zwitterionic lipids

100%

Hendrich A. B., Zugaj J., Michalak K.

Cellular and Molecular Biology Letters

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2002

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tom 07

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nr 2

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The effect of sugars on in vitro growth of Leucojum aestivum L. plants

80%

Ptak A., Moranska E., Simlat M., Skrzypek E., Warchol M., Nowak M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2015

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tom 96

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nr 1

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Lycopene - antioxidant with radioprotective and anticancer properties. A review

80%

Gajowik A., Dobrzynska M. M.

Roczniki Państwowego Zakładu Higieny

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2014

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tom 65

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nr 4

Ionizing radiation may cause damage to living tissue by producing free radicals like reactive oxygen species (ROS). ROS can randomly react with lipids, proteins and nucleic acids of cell causing oxidative stress and damage in these macromolecules, leading to pathogenesis of chronic diseases and age related and also cancer. The first line of defense from the damaging effects of ROS is antioxidants, which convert the oxidants to less reactive species. Lycopene (LYC) is an acyclic isomer of beta-carotene. It synthesized by plants or autotrophic bacteria but not by animals. Red fruits and vegetables, including tomatoes, watermelons, pink grapefruits, apricots, pink guavas and papaya contain LYC. This carotenoid has very strong antioxidant properties. The many studies confirm that dietary supplementation with LYC reduces risk of cancers of many organs, but also retard the growth of the tumors. LYC has also chemopreventive effects against other diseases such as cardiovascular disease, osteoporosis, male infertility and inhibits the toxic action of other agents. Numerous in vitro and animal studies showed that LYC may provide protection against damages induced by ionizing radiation. It suggests that supplementation of LYC might be useful in diminishing of negative effect of cancer radiotherapy or in mitigating the effects of possible radiation accidents on human health.

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Tumor regressive effect of grape juice [Enoant] on ehrlich ascites carcinoma of mice

80%

Taskin E. I., Yagci A., Firat U. B., Caner M., Dogruman H.

Medycyna Weterynaryjna

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2007

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tom 63

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nr 08

926-930

Enoant® is a nutritional reinforcement produced from the grape’s stem, peel and seeds. In recent years grape products such as wine and grape juice have acquired a great importance because of their polyphenol components, which have a strong antioxidant effect. Those antioxidant effects of polyphenols have an ability to inhibit proliferation and induce apoptosis in cancer depending on the types of cancer and application doses. In our study we have aimed to investigate the tumor regressive effects of Enoant® in solid EAC tumor model in Balb-c mice. Animals were randomly divided into 2 groups in this study. 0.5 ml of Enoant® was administered daily to ENTgroup and the same volume of NaCl 0.9% was administered to the control group. Animals continued to receive those applications till sacrification day. On the 8th day 2 × 10⁶ EAC cells in 0.5 ml NaCl 0.9% were injected subcutaneously into the mice’s napes. On day 22 all animals were sacrificed under ether anesthesia. Using PCNA immunohistochemical staining, TUNEL technique, we observed the proliferative and apoptotic cell density changes in tumor tissues as well as the effect of Enoant® on these two phenomena. Dietary Enoant® significantly regressed tumor development in mice. It has been observed that the administration of Enoant® displayed positive effects on EAC tumor’s weight and size when compared with control group animals. Mean tumor weights’ meaningfulness was p < 0.01 and mean short-long diameters’ meaningfulness were p < 0.05 and p<0.01, respectively. It has been determined that while the PCNA index was low (p < 0.05) in the Enoant® administered group, the apoptotic index that has been established with TUNEL technique was high (p < 0.01). As a result, Enoant® has a regressive function on EAC tumor cells. By inducing apoptosis, ENT inhibited the development of tumors. It is thought that ability of ENT was welded from its strong antioxidant polyphenol component. Because of that the use of Enoant® as a dietary supplement is thought to be a factor for inhibiting cancer development.

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Red power

51%

Brzezinska R.

Żywność, Żywienie, Życie. Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

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2002

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nr 3

Ograniczanie wyników

Immunomodulating and anticancer properties of fungi

In vitro anti-cancer properties of natural vs synthetic conjugated linoleic acid

Biochanin A similarly influences the fluidity of liposomes formed from charget and zwitterionic lipids

The effect of sugars on in vitro growth of Leucojum aestivum L. plants

Lycopene - antioxidant with radioprotective and anticancer properties. A review

Tumor regressive effect of grape juice [Enoant] on ehrlich ascites carcinoma of mice

Red power