Wyniki wyszukiwania

1

Antiproliferative activity of new benzimidazole derivatives

100%

Blaszczak-Swiatkiewicz K., Olszewska P., Mikiciuk-Olasik E.

Acta Biochimica Polonica

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2013

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tom 60

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nr 3

A series of new benzimidazole derivatives were synthesized and tested in vitro for possible anticancer activity. Their effect of proliferation into selected tumor cell lines at normoxia and hypoxia conditions was determined by WST-1 test. Additionally, apoptosis test (caspase 3/7 assay) was used to check the mode caused by the agents of cell death. Four of the examined compounds (7, 8, 13, 11) showed a very good antiproliferative effect and three of them were specific for hypoxia conditions (8, 14, 11). Compound 8 was the most cytotoxic against human lung adenocarcinoma A549 cells at hypoxic conditions. Hypoxia/ normoxia cytotoxic coefficient of compound 14 (4.75) is close to hypoxia/normoxia cytotoxic coefficient of tirapazamine (5.59) - a reference compound in our experiments and this parameter locates it between mitomycin C and 2-nitroimidazole (misonidazole). Screening test of caspase-dependent apoptosis proved that exposure to A549 cells of compounds 7-8 and 13-14 for 48 h promote apoptotic cell death. These results supplement our earlier study of the activity of new potentialy cytotoxic heterocyclic compounds against selected tumor cells.

2

The effects of taxol [paclitaxel] on chemiluminescence of neutrophils, macrophages and J.774.2 cell line

100%

Czuba Z. P., Krol W., Hasinski P., Nowowiejska A.

Acta Biochimica Polonica

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1998

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tom 45

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nr 1

Taxol (paclitaxel) is a chemotherapeutic diterpene with promising anticancer activity that blocks cell division by preventing microtubule depolymerization. Furthermore, recent studies have shown that taxol has other intracellular effects that may contribute to its effect, particularly in macrophages. The signal transduction mechanisms by which taxol stimulates macrophages to anticancer activity are not clear. The purpose of this study was to determine the effect of taxol on chemiluminescence (an indicator of the production of free radicals) of neutrophils, macrophages and murine macrophage J.774.2 cells. The chemiluminescence was measured in the presence of taxol andór phorbol myristate acetate (PMA) as a stimulant. Taxol stimulated chemiluminescence (without PMA) of neutrophils and macrophages but not of J.774.2 cells, and modulated chemiluminescence of the cells stimulated with PMA.

3

Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis[2- and 4-formylaryloxymethyl]pyridines

100%

Kuz'min V. E., Lozitsky V. P., Kamalov G. L., Lozitskaya R. N., Zheltvay A. I., Fedtchouk A. S., Kryzhanovsky D. N.

Acta Biochimica Polonica

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2000

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tom 47

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nr 3

Quantitative estimation of the structure anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.

4

The analysis of structure-anticancer and antiviral activity relationships for macrocyclic pyridinophanes and their analogues on the basis of 4D QSAR models [simplex representation of molecular structure]

100%

Kuz'min V. E., Artemenko A. G., Lozitsky V. P., Muratov E. N., Fedtchouk A. S., Dyachenko N. S., Nosach L. N., Gridina T. L., Shitikova L. I., Mudrik L. M., Mescheriakov A. K., Chelombitko V. A., Zheltvay A. I., Vanden Eynde J. J.

Acta Biochimica Polonica

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2002

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tom 49

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nr 1

A new 4D-QSAR approach has been considered. For all investigated molecules the 3D structural models have been created and the set of conformers (fourth dimension) have been used. Each conformer is represented as a system of different simplexes (tetratomic fragments of fixed structure, chirality and symmetry). The investigation of influence of molecular structure of macrocyclic pyridino- phanes, their analogues and certain other compounds on anticancer and antiviral (anti-influenza, antiherpes and antiadenovirus) activity has been carried out by means of the 4D-QSAR. Statistic characteristics for QSAR of PLS (partial least squares) models are satisfactory (R = 0.92-0.97; CVR = 0.63-0.83).

5

Molecular targets of [-]-epigallocatechin-3-gallate [EGCG]: specificity and interaction with membrane lipid rafts

84%

Patra S. K., Rizzi F., Silva A., Rugina D. O., Bettuzzi S.

Journal of Physiology and Pharmacology. Supplement

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2008

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tom 59

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nr 9

217-235

6

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Synthesis and in vitro anticancer activity of N-alkyl phosphoramidate monoesters of 3N-azido-3N-deoxythymidine (AZT)

84%

Czajkowska-Wojciechowska E., Singh A., Trznadel R., Ruszkowski P., Celewicz L.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2019

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tom 100

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nr 1

7

The wine polyphenol resveratrol modulates autophagy and induces apoptosis in MOLT-4 and HL-60 human leukemia cells

84%

Siedlecka-Kroplewska K., Wozniak M., Kmiec Z.

Journal of Physiology and Pharmacology

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2019

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tom 70

|

nr 6

8

Synthetic derivatives of genistein, their properties and possible applications

84%

Rusin A., Krawczyk Z., Grynkiewicz G., Gogler A., Zawisza-Puchalka J., Szeja W.

Acta Biochimica Polonica

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2010

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tom 57

|

nr 1

23-34

Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of potential medicinal interest, but also as a food supplement or prospective chemopreventive agent. Since its physicochemical properties are considered suboptimal for drug development, much effort has been invested in designing its analogs and conjugates in hope to obtain compounds with improved efficacy and selectivity. The aim of this article is to summarize current knowledge about the properties of synthetic genistein derivatives and to discuss possible clinical application of selected novel compounds. Some basic information concerning chemical reactivity of genistein, relevant to the synthesis of its derivatives, is also presented.

9

Antibacterial effect of an extract of the endophytic fungus Alternaria alternata and its cytotoxic activity on MCF-7 and MDA MB-231 tumour cell lines

84%

Arivudainambi E., Kanugula A. K., Kotamraju S., Karunakaran C., Rajendran A.

Biological Letters

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2014

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tom 51

|

nr 1

10

5'-Esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with cell differentiation-provoking agents

84%

Grieb P., Kryczka T., Wojtowicz R., Kawiak J., Kazimierczuk Z.

Acta Biochimica Polonica

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2002

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tom 49

|

nr 1

Phenylacetic and retinoic acids are carboxyacidic cell differentiating agents displaying anticancer activities. We report on a new class of compounds including the 5'-es- ters of 2'-deoxyadenosine (dA) or 2-chloro-2'-deoxyadenosine (cladribine, 2CdA) and the aforementioned acids. The rationale behind the synthesis of these esters was that if they are hydrolyzed inside the lymphoid cells, either dA will be removed from the intracellular environment by deamination, or 2CdA will be phosphorylated and accumulated. In either case targetted delivery of the differentiating agent to the lymphoid cells may be envisaged. The said compounds were synthesized by the Mitsunobu procedure employing triphenylphosphine and azadicarboxylic acid esters, and their stability was tested against various esterases. Esters of dA and 2CdA with phenylacetic acids were found to be resistant to enzymatic hydrolysis, whereas those with retinoic acids were efficiently hydrolyzed by commercially available hepatic esterase as well as by esterases present in the blood plasma and in diluted human lymphocyte lysate. Susceptibility to enzymatic hydrolysis was found to be a prerequisite of cytotoxic and/or differentiating activity of these esters in leukemic cell lines.

11

Recognition and repair of DNA-cisplatin adducts

84%

Wozniak K., Blasiak J.

Acta Biochimica Polonica

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2002

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tom 49

|

nr 3

Anticancer activity of cisplatin (cis-diamminedichloroplatinum) is believed to result from its interaction with DNA. The drug reacts with nucleophilic sites in DNA forming monoadducts as well as intra- and interstrand crosslinks. DNA-cisplatin adducts are specifically recognized by several proteins. They can be divided into two classes. One constitutes proteins which recognize DNA damage as an initial step of the nucleotide excision and mismatch repair pathways. The other class contains proteins stabilizing cellular DNA-protein and protein-protein complexes, including non-histone proteins from the HMG (high-mobility-group) family. They specifically recognize 1,2-inter- strand d(GpG) and d(ApG) crosslinks of DNA-cisplatin adducts and inhibit their repair. Many HMG-domain proteins can function as transcription factors, e.g. UBF, an RNA polymerase I transcription factor, the mammalian testis-determining factor SRY and the human mitochondrial transcription factor mtTFA. Moreover, it seems that some proteins, which probably recognize DNA-cisplatin adducts non-specifically, e.g. actin and other nuclear matrix proteins, can disturb the structural and functional organization of the nucleus and whole cell. The formation of complexes between DNA and proteins in the presence of cisplatin and the changes in the cell architecture may account for the drug cytotoxicity.

12

The storage ability of lamb’s lettuce cultivated in the greenhouse under led or HPS lamps

67%

Kolton A., Wojciechowska R., Dlugosz-Grochowska O., Grzesiak W.

Journal of Horticultural Research

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2014

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tom 22

|

nr 2

13

The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells

67%

Juszczak M., Matysiak J., Niewiadomy A., Rzeski W.

Folia Histochemica et Cytobiologica

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2011

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tom 49

|

nr 3

14

The anticancer activity of propolis

67%

Sawicka D., Car H., Borawska M. H., Niklinski J.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 1

15

Anticancer and antioxidant effects of fructooligosaccharide (FOS) on chemically-induced colon cancer in rats

67%

Moharib S. A.

Electronic Journal of Polish Agricultural Universities. Series Veterinary Medicine

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2016

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tom 19

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nr 1

16

Behavior of Listeria innocua strains under pressure treatment - inactivation and sublethal injury

67%

Nasilowska J., Sokolowska B., Fonberg-Broczek M.

Polish Journal of Food and Nutrition Sciences

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2019

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tom 69

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nr 1

The inactivation and sublethal injury of two strains of Listeria innocua (one collection strain and one wild strain isolated from beetroot juice) suspended in beetroot juice and in model solutions, after high hydrostatic pressure (HHP) were investigated. Changes within the population assessed by plating count methods of both L. innocua strains suspended in a buffer pH 4.0 were more noticeable than in the natural beetroot juice environment. In beetroot juice the lethal effect was reported after 1 min of pressure treatment at 400 MPa for the collection strain. In the case of the wild type strain, exposure to the maximal parameters of the compression process (400 MPa, 10 min) decreased the population number below 1 log (CFU/mL) but did not cause complete injury. The collection strain of L. innocua was easier to inactivate in beetroot juice than the strain isolated from this environment. The maximum level of sublethal injury was observed when the cells were suspended in a buffer pH 7.0. Structural damage in cell membranes after HHP processing was observed using a transmission electron microscope (TEM).

17

Production of bioactive metabolites from different marine endophytic Streptomyces species and testing them against methicillin-resistant Staphylococcus aureus (MRSA) and cancer cell lines

67%

El-Gendy M. M. A. A., Mohamed Z. K., Hekal N. Z., Ali F. M., Yousef A. E. M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2018

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tom 99

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nr 1

18

Ziolomiod zawierajacy sulforafan - aglikon o potencjalnej roli w profilaktyce chorob nowotworowych

67%

Swiderski A., Sterkowicz P., Kaszycki P., Koloczek H.

Roczniki Państwowego Zakładu Higieny

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2003

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tom 54

|

nr 1

25-32

Produkty przemian glukozynolanów obecnych w brokułach, takie jak sulforafan, wykazują pozytywne działanie fizjologiczne i biochemiczne na organizm człowieka, w szczególności hamując rozwój nowotworów. W pracy opisano hydrolizę glukozynolanów oraz ekstrakcję i transfer sulforafanu do ziołomiodu. Otrzymano ziołomiód o stężeniu sulforafanu w zakresie jego aktywności biologicznej.

19

Differential antitumor effect of essential oils and their major components of Thymus broussonettii: relationship to cell cycle and apoptosis induction

67%

Jaafari A., Ait Mouse H., Ait M'Bark L., Tilaoui M., Elhansali M., Lepoivre M., Aboufatima R., Melhaoui A., Chait A., Zyad A.

Herba Polonica

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2009

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tom 55

|

nr 2

36-50

Thymus broussonettii, a Moroccan endemic plant, exists in two chemotypes. The aim of our study is to compare the cytotoxic activity of their essential oils and major products as well as their effect on cell cycle and apoptosis induction. The chemical composition analysis of essential oils by GC-SM revealed that the lasts are rich and diverse and the major products of the chemotypes TbA and TbE are carvacrol and thymol, respectively. The in vitro cytotoxic effect study against five tumor cell lines shows that TbA essential oil, rich in carvacrol, has an important cytotoxic effect, higher than that of TbE, rich in thymol. This result is confirmed by comparing cytotoxic effect of carvacrol and thymol. Furthermore, TbA EO /carvacrol and TbE EO /thymol induce cell cycle arrest at S and G0/G1 phases, respectively. On the other hand, carvacrol, most cytotoxic in vitro, was studied for its effect on solid tumor in vivo and apoptosis-induction. Our results show that carvacrol, administred by gavage, has an important effect on solid tumor and induce apoptosis in P815 tumor cell line.

20

Molekularne mechanizmy przeciwnowotworowego dzialania czosnku . Rola reaktywnych form tlenu

67%

Debski B., Milner J. A.

Bromatologia i Chemia Toksykologiczna

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2007

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tom 40

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nr 3

223-228

Ograniczanie wyników

Antiproliferative activity of new benzimidazole derivatives

The effects of taxol [paclitaxel] on chemiluminescence of neutrophils, macrophages and J.774.2 cell line

Analysis of the structure - anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis[2- and 4-formylaryloxymethyl]pyridines

The analysis of structure-anticancer and antiviral activity relationships for macrocyclic pyridinophanes and their analogues on the basis of 4D QSAR models [simplex representation of molecular structure]

Molecular targets of [-]-epigallocatechin-3-gallate [EGCG]: specificity and interaction with membrane lipid rafts

Synthesis and in vitro anticancer activity of N-alkyl phosphoramidate monoesters of 3N-azido-3N-deoxythymidine (AZT)

The wine polyphenol resveratrol modulates autophagy and induces apoptosis in MOLT-4 and HL-60 human leukemia cells

Synthetic derivatives of genistein, their properties and possible applications

Antibacterial effect of an extract of the endophytic fungus Alternaria alternata and its cytotoxic activity on MCF-7 and MDA MB-231 tumour cell lines

5'-Esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with cell differentiation-provoking agents

Recognition and repair of DNA-cisplatin adducts