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Quantification of the ash content from biofuel - wood according to ISO 1171 (2003) and EN 14775 (2010)

100%

Dzurenda L., Pnakovic L.

Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology

2014

tom 86

Molecular modelling of the vasopressin V2 receptor-antagonist interactions

84%

Czaplewski C., Kazmierkiewicz R., Ciarkowski J.

Acta Biochimica Polonica

1998

tom 45

nr 1

We predict some essential interactions between the V2 vasopressin renal receptor (V2R) and its selective peptide antagonist desGly9-[Mca1,D-Ile2,Ile4]AVP, and compare these predictions with the earlier ones for the non-peptide OPC-36120 antagonist- and the [Arg8]vasopressin (AVP) agonist-V2 receptor interactions. V2R controls antidiuresis in mammals and belongs to the superfamily of the heptahelical transmembrane (7TM) G protein-coupled receptors (GPCR)s. V2R was built, the ligands docked and the structures relaxed using advanced molecular modeling techniques. Both the agonist and the antagonists (no matter whether of peptide- or non-peptide type) appear to prefer a common V2R compartment for docking. The receptor amino-acid residues, potentially important in ligand binding, are mainly in the TM3-TM7 helices. A few of these residues are invariant for the whole GPCR superfamily while most of them are conserved in the subfamily of neurohypophyseal receptors, to which V2R belongs. Some of the equivalent residues in a related V1a receptor have been earlier reported as critical for the ligand affinity.

Ograniczanie wyników

1 Acta Biochimica Polonica

1 Annals of Warsaw University of Life Sciences - SGGW. Forestry and Wood Technology

1 Ciarkowski J.

1 Czaplewski C.

1 Dzurenda L.

1 Kazmierkiewicz R.

1 Pnakovic L.

1 2014

1 1998

Wyniki wyszukiwania

Quantification of the ash content from biofuel - wood according to ISO 1171 (2003) and EN 14775 (2010)

Molecular modelling of the vasopressin V2 receptor-antagonist interactions