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On the basis of data from literature and author’s own experiments, characteristics of anesthesia by a continuous infusion have presented. This type of procedure reduces the potent dose of short-acting anesthetics. Their clinical specificity is better used and their disadvantageous influence on respiratory and cardiovascular function partly eliminated. Continuous administering of a low concentrate solution of agents is safer than a traditional way of application (dosis singularis). The described method allows for a more effective control of the level and time of surgical tolerance.
Propofol is an intravenous anaesthetic in which the active substance is 2.6-diizopropylphenol. It may be used for intravenous infusions in single or fractionated doses. Propofol was applied to 25 sheep of both sexes. Anaesthesia was induced with a saturation dose of 6.75 mg/kg bw/min. Afterwards, the substance was applied in sustaining doses. The total dose of Propofol was 0.44 mg/kg bw/min. The animals were under anaesthesia for 45 min. Haematological and biochemical parameters in sheep (10 examined animals) varied within the normal range. Myorelaxation and analgesia proved to be good. When Propofol administration ceased, the animals woke up quite quickly and attained the same state as before anaesthesia. In the course of anaesthesia Propofol should be administered continuously.
The objective of the work was to establish in dogs the effects of propofol anaesthesia without premedication in a single dose and in continuous infusion on blood gas exchange and on haematological parameters. Propofol injected in a single dose of 6.5 mg/kg bw evokes a general anaesthesia lasting for about 5 min. Propofol used continuously at a dose of about 0.5 mg/kg bw/min. enables to obtain a general anaesthesia easy to control in depth and time. In the anaesthesia after a continuous infusion of propofol a transient respiratory acidosis and a decrease of blood oxygenation appears. Moreover, a short-lived statistically significant increase of pulmonary shunt develops.
The paper presents observations collected from 7 horses during general anaesthesia with controlled ventilation (CV) used for surgical procedures (laparotomy, correction of long bone fractures). After the horses had been restrained (guiphenesin 0.1 g/kg b.w.), spontaneous ventilation was eliminated by the use of muscle relaxant (pancuronium 0.1 mg/kg b.w.) and replaced by CV (IPPV = 25-35 cm H2O f = 13, Vmin = 52 1/min, I/E = 2:3) realized by the „bag in bix” respirator. General anesthesia was maintained using an inhalation technique for an average of 110 min. using 2 vol% halothane with oxygen administered in a quantity of 2.5-3.5 1/min. Artificial ventilation maintaining breathing higher than natural (values Vt and V min) protected the horses from metabolic disturbances. The anesthesia performed with an anaesthetic-respiratory apparatus made in our department according to the conception of the author was characterized by a complication free course with a preferably rapid induction and a fast recovery. The variant of anaesthetization with mechanical respirators should be applied for long-lasting operations where full relaxation and no motion is required. This type of procedure gives better conditions for work the abdominal cavity and orthopedic procedures.
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