Wyniki wyszukiwania

1

Assessment of analgesic effects of different initial doses of transdermal buprenorphine in the treatment of chronic pain in the elderly diagnosed with osteoarthritis

100%

Widenka M., Leppert W.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 5

2

Clinical use of the parasympathetic tone activity index as a measurement of postoperative analgaesia in dogs undergoing ovariohysterectomy

100%

Hernandez-Avalos I., Valverde A., Ibancovichi-Camarillo J. A., Sanchez-Aparicio P., Recillas-Morales S., Rodriguez-Velazquez D., Osorio-Avalos J., Magdaleno-Torres L. A., Chavez-Monteagudo J., Acevedo-Arcique C. M.

Journal of Veterinary Research

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2021

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tom 65

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nr 1

3

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The effect of naloxone on trigemino-hypoglossal reflex inhibited by periaqueductal central gray stimulation in rats

100%

Zubrzycka M., Janecka A.

Journal of Physiology and Pharmacology

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2000

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tom 51

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nr 3

4

High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice

84%

Zielinska M., Szymaszkiewicz A., Salaga M., Zatorski H., Wlodarczyk J., Jacenik D., Kordek R., Krajewska W. M., Misicka A., Fichna J., Sacharczuk M.

Journal of Physiology and Pharmacology

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2018

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tom 69

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nr 5

5

Evaluation of the safety and effects of pregabalin premedication on sleep quality, haemodynamic changes and pain in elderly patients with comorbidities undergoing spinal stenosis

84%

Kilic E. T.

Journal of Pre-Clinical and Clinical Research

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2020

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tom 14

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nr 4

6

The effects of wetted ice on dynamic stability over a rewarming period

84%

Alexander J., Mawene Y., Alexanders J., Jeffery J., Rhodes D.

Central European Journal of Sport Sciences and Medicine

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2023

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tom 41

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nr 01

7

Caudal extradural analgesia with lidocaine, xylazine, and a combination of lidocaine and xylazine in the Iranian river buffalo

84%

Saifzadeh S., Pourjafar M., Naghadeh B. D., Jalali F. S. S.

Bulletin of the Veterinary Institute in Puławy

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2007

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tom 51

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nr 2

This study was conducted to compare the time of onset, duration of action, and the extent of analgesia produced by a lidocaine/xylazine combination with those produced by lidocaine and xylazine alone after injection into the caudal extradural space of the Iranian river buffalo. The study was designed as a prospective, descriptive, observer-blind trial, in a Latin square pattern. Eleven adult (aged over 2 years) non- gravid and healthy females of Iranian river buffaloes (Bubalus bubalis), weighing from 450 to 650 kg, were used. Caudal extradural analgesia was achieved on 3 occasions at 14 d intervals by injection of 2% lidocaine (L; 0.22 mg kg⁻¹), 2% xylazine (X; 0.05 mg kg⁻¹), and a combination of 2% lidocaine(0.22 mg kg⁻¹) / 2% xylazine (LX; 0.05 mg kg⁻¹) in a Latin square design. Analgesia was determined by the lack of response to pinprick and haemostat pressure in the skin of the caudal areas. X was significantly longer (5.5 ± 0.7 min) than that by L or LX. Duration of analgesia was significantly longer by LX (172.3 ± 17.7 min) than that by either drug used alone (lidocaine, 79.5 ± 5.7 min; xylazine, 136.4±11.4 min). In X and LX groups, the level of analgesia ascended to thoracic segments; however, in lidocaine-treated buffaloes thighs, flank, and udders remained sensitive. In all the buffaloes, xylazine, administered either alone or with lidocaine, induced mild to moderate ataxia. It was concluded that the LX combination provided a more rapid onset and a longer duration of analgesia, and a more cranial spread of analgesic effect compared with either drug alone. As a result, the LX combination may offer a fast and long lasting anaesthesia/analgesia to perform obstetrical and surgical procedures without the need for re-injection.

8

The effect of an endogenous compound 1-methyl-1,2,3,4-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures

84%

Wasik A., Romanska I., Antkiewicz-Michaluk L.

Journal of Physiology and Pharmacology

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2007

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tom 58

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nr 2

1,2,3,4-Tetrahydroisoquinolines, among them the most interesting neuroprotective substance, an inhibitor of MAO, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), are endogenous compounds present in the central nervous system of mammals and humans. In this study, we investigated the effect of 1MeTIQ on morphine-induced analgesia, tolerance and abstinence syndrome as well as its effect on morphine-induced changes in dopamine metabolism in rat brain structures (nucleus accumbens, striatum, substantia nigra) using HPLC methodology. The experiments were carried out on male Wistar rats. Morphine analgesia was measured in the “hot-plate” test. To induce tolerance, morphine was given chronically (20 mg/kg i.p.) alone or following 1MeTIQ (50 mg/kg i.p.) injection. The development of dependence was assessed in the naloxone (2 mg/kg i.p.) precipitation test, after 10 days of morphine administration. The behavioral studies have shown that an endogenous compound, 1MeTIQ produced strong potentiation of morphine analgesia, prevented the development of morphine tolerance and inhibited expression of morphine abstinence syndrome in morphine-dependent rats. In neurochemical studies, we have demonstrated that 1MeTIQ antagonized morphine-induced changes in dopamine metabolism observed in rat brain structures. The main finding of this study was demonstration for the first time of an anti-abuse effect of an endogenous compound, 1MeTIQ, and its efficiency in counteracting morphine-induced addiction in the way useful from clinical point of view. The obtained results suggested a possibility of clinical application of 1MeTIQ in morphine addiction.

9

The analgesic and anticonvulsant effects of piperine in mice

67%

Bukhari I. A., Alhumayyd M. S., Mahesar A. L., Gilani A. H.

Journal of Physiology and Pharmacology

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2013

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tom 64

|

nr 6

10

Dual peripheral actions of immune cells in neuropathic pain

67%

Machelska H.

Archivum Immunologiae et Therapiae Experimentalis

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2011

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tom 59

|

nr 1

11

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice

67%

Boban Blagaic A., Turcic P., Blagaic V., Dubovecak M., Jelovac N., Zemba M., Radic B., Becejac T., Stancic Rokotov D., Sikiric P.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 7

12

Endogenous systems involved in exercise-induced analgesia

67%

Da Silva Santos R., Galdino G.

Journal of Physiology and Pharmacology

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2018

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tom 69

|

nr 1

13

Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS)

67%

Miranda H. F., Pinardi G.

Journal of Physiology and Pharmacology

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2009

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tom 60

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nr 2

71-76

To enhance analgesia, combination of analgesics drugs of proven efficacy is a strategy which is accompanied by a reduction of adverse effects. The present study was undertaken to characterize the antinociceptive interaction of morphine with different non-steroidal anti-inflammatory drugs (NSAIDs) using isobolographic analysis and the writhing test of mice. One of the possible mechanisms of action of spinally administered morphine with non-steroidal anti-inflammatory drugs was investigated using the DOR antagonist naltrindole. The study demonstrated a synergistic antinociception of spinal administered combinations of morphine with the following NSAIDs agents: diclofenac, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam. The supraadditive effect seems to be independent of the selectivity of each NSAIDs to inhibit COX-1 or COX-2. The findings of the present work suggest that the combinations of opioids and non-steroidal anti-inflammatory drugs have a direct action on spinal processing of the nociceptive information, which may achieved by additional mechanisms independent of prostaglandin synthesis inhibition and/or activation of opioid receptors. The lack of effect of naltrindole to modify the analgesic activity of the combination of opioids and NSAIDs indicates that others pain regulatory systems are involved in this central action. Therefore, these combinations could be a viable alternative to clinical pain management, especially trough multimodal analgesia.

14

Central corticotropin–releasing factor (CRF) may attenuate somatic pain sensitivity through involvement of glucocorticoids

67%

Yarushkina N. I., Bagaeva T. R., Filaretova L. P.

Journal of Physiology and Pharmacology

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2011

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tom 62

|

nr 5

15

Spinal effects of the calmodulin inhibitor calmidazolium on dorsal horn neurons in the rat

67%

Menendez L., Baamonde A., Hidalgo A.

Acta Neurobiologiae Experimentalis

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1999

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tom 59

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nr 1

16

Post-stress analgesia in rats with partial amygdala lesions

67%

Werka T.

Acta Neurobiologiae Experimentalis

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1994

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tom 54

|

nr 2

17

Non-opioid peptides for analgesia

59%

Chrubasik J., Chrubasik S., Martin E.

Acta Neurobiologiae Experimentalis

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1993

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tom 53

|

nr 1

Ograniczanie wyników

Assessment of analgesic effects of different initial doses of transdermal buprenorphine in the treatment of chronic pain in the elderly diagnosed with osteoarthritis

Clinical use of the parasympathetic tone activity index as a measurement of postoperative analgaesia in dogs undergoing ovariohysterectomy

The effect of naloxone on trigemino-hypoglossal reflex inhibited by periaqueductal central gray stimulation in rats

High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice

Evaluation of the safety and effects of pregabalin premedication on sleep quality, haemodynamic changes and pain in elderly patients with comorbidities undergoing spinal stenosis

The effects of wetted ice on dynamic stability over a rewarming period

Caudal extradural analgesia with lidocaine, xylazine, and a combination of lidocaine and xylazine in the Iranian river buffalo

The effect of an endogenous compound 1-methyl-1,2,3,4-tetrahydroisoquinoline on morphine-induced analgesia, dependence and neurochemical changes in dopamine metabolism in rat brain structures

The analgesic and anticonvulsant effects of piperine in mice

Dual peripheral actions of immune cells in neuropathic pain

Gastric pentadecapeptide BPC 157 counteracts morphine-induced analgesia in mice

Endogenous systems involved in exercise-induced analgesia

Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS)

Central corticotropin–releasing factor (CRF) may attenuate somatic pain sensitivity through involvement of glucocorticoids

Spinal effects of the calmodulin inhibitor calmidazolium on dorsal horn neurons in the rat

Post-stress analgesia in rats with partial amygdala lesions

Non-opioid peptides for analgesia