Wyniki wyszukiwania

1

Pasazowalne amyloidozy mozgowe czyli choroby wywolane przez priony: czy struktura czynnika scrapie jest juz rzeczywiscie znana?

100%

Liberski P., Bartosiewicz J.

Postępy Biochemii

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1996

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tom 42

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nr 4

320-330

2

Egg yolk platelet proteins from Xenopus laevis are amyloidogenic

100%

Zemanek G., Konieczny L., Piekarska B., Rybarska J., Stopa B., Spolnik P., Urbanowicz B., Nowak M., Krol M., Roterman I.

Folia Histochemica et Cytobiologica

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2002

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tom 40

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nr 3

3

The structure and protein binding of amyloid-specific dye reagents

100%

Stopa B., Piekarska B., Konieczny L., Rybarska J., Spolnik P., Zemanek G., Roterman I., Krol M.

Acta Biochimica Polonica

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2003

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tom 50

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nr 4

The self-assembling tendency and protein complexation capability of dyes related to Congo red and also some dyes of different structure were compared to explain the mechanism of Congo red binding and the reason for its specific affinity for /3-struc- ture. Complexation with proteins was measured directly and expressed as the number of dye molecules bound to heat-aggregated IgG and to two light chains with different structural stability. Binding of dyes to rabbit antibodies was measured indirectly as the enhancement effect of the dye on immune complex formation. Self-assembling was tested using dynamic light scattering to measure the size of the supra- molecular assemblies. In general the results show that the supramolecular form of a dye is the main factor determining its complexation capability. Dyes that in their compact supramolecular organization are ribbon-shaped may adhere to polypeptides of /3-conformation due to the architectural compatibility in this unique structural form. The optimal fit in complexation seems to depend on two contradictory factors involving, on the one hand, the compactness of the non-covalently stabilized supra- molecular ligand, and the dynamic character producing its plasticity on the other. As a result, the highest protein binding capability is shown by dyes with a moderate self-assembling tendency, while those arranging into either very rigid or very unstable supramolecular entities are less able to bind.

4

Prion disease and Alzheimer's disease: pathogenic overlap

100%

Castellani R. J., Perry G., Smith M. A.

Acta Neurobiologiae Experimentalis

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2004

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tom 64

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nr 1

5

Regulation of mouse serum amyloid A3 gene expression during acute phase reaction

100%

Shimizu H., Mitomo K., Yamamoto K.

Folia Histochemica et Cytobiologica

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1992

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tom 30

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nr 4

6

Ultrastructural features of the neurovascular unit in Alzheimer's neurodegeneration

84%

Frontczak-Baniewicz M., Walski M.

Journal of Physiology and Pharmacology. Supplement

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2006

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tom 57

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nr 4

91-96

Recent studies suggest that capillaries, neurons, and astrocytes form a functional unit that serves to maintain cerebral homeostasis. Physiological interactions between all these components of the neurovascular unit control cerebral microcirculation, while abnormal regulatory mechanisms lead to cerebral dysfunction and disease states, such as Alzheimer’s disease (AD). Using electron microscopy, we studied a fragment of the frontotemporal cortex obtained intraoperatively from a patient with established AD. The objective of our study was to assess the ultrastructure of the components of the neurovascular unit. Such ultrastructural studies allow analyzing the structural process of new blood vessels formation and also the appearance of neurons and astrocytes contributing to the neurovascular unit. We suggest that dysfunction of particular components of the neurovascular unit underlies AD and ultimately leads to neurodegeneration.

7

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3D domain swapping – implications for conformational disorders and ways of control

67%

Jaskolski M.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2011

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tom 92

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nr 1

8

Mechanizmy starzenia się ośrodkowego układu nerwowego u zwierząt

67%

Firlag M., Ostaszewski P., Balasinska B.

Życie Weterynaryjne

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2014

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tom 89

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nr 01

9

Amyloidy, białka powszechne wśród drobnoustrojów

67%

Pawlowska B. K., Sobieszczanska B. M.

Postępy Mikrobiologii

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2017

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tom 56

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nr 1

10

Effect of amyloid beta peptide on poly[ADP-ribose] polymerase activity in adult and aged rat hippocampus

67%

Strosznajder J. B., Jesko H., Strosznajder R. P.

Acta Biochimica Polonica

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2000

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tom 47

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nr 3

It is suggested that the fibrillar amyloid beta peptide (Abeta) in brain plays a direct role in neurodegeneration in Alzheimer's disease, probably through activation of reactive oxygen species formation. Free radicals and numerous neurotoxins elicit DNA damage that subsequently activates poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30). In this study the effect of neurotoxic fragment (25-35) of full length Abeta peptide on PARP activity in adult and aged rat hippocampus was investigated. In adult (4 month old) rat hippocampus the Abeta 25-35 peptide significantly enhanced PARP activity by about 80% but had no effect on PARP activity in cerebral cortex and in hippocampus from aged (24-27 month old) rats. The effect of Abeta peptide was reduced by half by the nitric oxide synthase inhibitor N-nitro-L-arginine. Stimulation of glutamate receptor(s) itself enhanced PARP activity by about 80% in adult hippocampus. However, Abeta 25-35 did not exert any additional stimulatory effect. These results indicate that Abeta, through NO and probably other free radicals, induces activation of DNA bound PARP activity exclusively in adult but not in aged hippocampus.

Ograniczanie wyników

Pasazowalne amyloidozy mozgowe czyli choroby wywolane przez priony: czy struktura czynnika scrapie jest juz rzeczywiscie znana?

Egg yolk platelet proteins from Xenopus laevis are amyloidogenic

The structure and protein binding of amyloid-specific dye reagents

Prion disease and Alzheimer's disease: pathogenic overlap

Regulation of mouse serum amyloid A3 gene expression during acute phase reaction

Ultrastructural features of the neurovascular unit in Alzheimer's neurodegeneration

3D domain swapping – implications for conformational disorders and ways of control

Mechanizmy starzenia się ośrodkowego układu nerwowego u zwierząt

Amyloidy, białka powszechne wśród drobnoustrojów

Effect of amyloid beta peptide on poly[ADP-ribose] polymerase activity in adult and aged rat hippocampus