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Regulation of alternative splicing by RNA secondary structure

100%

Lisowiec J., Dominiak G., Kierzek R.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2014

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tom 95

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nr 3

2

The soluble CTLA-4 receptor: a new marker in autoimmune diseases

100%

Pawlak E., Kochanowska I. E., Frydecka I., Kielbinski M., Potoczek S., Bilinska M.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

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nr 4

3

Alternative splicing in the Atp7a gene in the Cu deficient mosaic mutation in mice

100%

Lenartowicz M., Grzmil P., Rusin M., Styrna J.

Folia Biologica

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2004

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tom 52

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nr 3-4

4

Glucocorticoid receptor beta splice variant expression in patients with high and low activity of systemic lupus erythematosus

84%

Piotrowski P., Burzynski M., Lianeri M., Mostowska M., Wudarski M., Chwalinska-Sadowska H., Jagodzinski P. P.

Folia Histochemica et Cytobiologica

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2007

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tom 45

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nr 4

339-342

5

Computational analysis of alternative spliced genes on maize chromosome 1

84%

Gracz J., Swiercz A., Twardowski T.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2012

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tom 93

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nr 1

6

Regulatory mechanisms of gene expression: complexity with elements of deterministic chaos

84%

Jura J., Wegrzyn P., Jura J., Koj A.

Acta Biochimica Polonica

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2006

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tom 53

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nr 1

Linear models based on proportionality between variables have been commonly applied in biology and medicine but in many cases they do not describe correctly the complex relationships of living organisms and now are being replaced by nonlinear theories of deterministic chaos. Recent advances in molecular biology and genome sequencing may lead to a simplistic view that all life processes in a cell, or in the whole organism, are strictly and in a linear fashion controlled by genes. In reality, the existing phenotype arises from a complex interaction of the genome and various environmental factors. Regulation of gene expression in the animal organism occurs at the level of epigenetic DNA modification, RNA transcription, mRNA translation, and many additional alterations of nascent proteins. The process of transcription is highly complicated and includes hundreds of transcription factors, enhancers and silencers, as well as various species of low molecular mass RNAs. In addition, alternative splicing or mRNA editing can generate a family of polypeptides from a single gene. Rearrangement of coding DNA sequences during somatic recombination is the source of great variability in the structure of immunoglobulins and some other proteins. The process of rearrangement of immunoglobulin genes, or such phenomena as parental imprinting of some genes, appear to occur in a random fashion. Therefore, it seems that the mechanism of genetic information flow from DNA to mature proteins does not fit the category of linear relationship based on simple reductionism or hard determinism but would be probably better described by nonlinear models, such as deterministic chaos.

7

On the biological relevance of alternative splicing in plants: dual function of an Arabidopsis membrane transporter

67%

Doque P.

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

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2013

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tom 94

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nr 3

8

Cycle dependent LH-hCG receptor gene expression in porcine nongonadal reproductive tissues

67%

Derecka K., Pietila E. M., Rajaniemi H. J., Ziecik A. J.

Journal of Physiology and Pharmacology

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1995

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tom 46

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nr 1

9

Modulation of corticotropin releasing factor (CRF) signaling through receptor splicing in mouse pituitary cell line AtT-20 - emerging role of soluble isoforms

59%

Zmijewski M. A., Slominski A. T.

Journal of Physiology and Pharmacology. Supplement

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2009

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tom 60

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nr 4

Ograniczanie wyników

Regulation of alternative splicing by RNA secondary structure

The soluble CTLA-4 receptor: a new marker in autoimmune diseases

Alternative splicing in the Atp7a gene in the Cu deficient mosaic mutation in mice

Glucocorticoid receptor beta splice variant expression in patients with high and low activity of systemic lupus erythematosus

Computational analysis of alternative spliced genes on maize chromosome 1

Regulatory mechanisms of gene expression: complexity with elements of deterministic chaos

On the biological relevance of alternative splicing in plants: dual function of an Arabidopsis membrane transporter

Cycle dependent LH-hCG receptor gene expression in porcine nongonadal reproductive tissues

Modulation of corticotropin releasing factor (CRF) signaling through receptor splicing in mouse pituitary cell line AtT-20 - emerging role of soluble isoforms