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1

Alpha-ketoglutarate as a molecule with pleiotropic activity: well-known and novel possibilities of therapeutic use

100%
Zdzisinska B., Zurek A., Kandefer-Szerszen M.
Archivum Immunologiae et Therapiae Experimentalis
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2017
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tom 65
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nr 1
2

Effect of alpha-ketoglutarate [AKG] on mineralisation, morphology and mechanical endurance of femur and tibia in turkey

100%
Tatara M. R., Pierzynowski S. G., Majcher P., Krupski W., Brodzki A., Studzinski T.
Bulletin of the Veterinary Institute in Puławy
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2004
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tom 48
|
nr 3
3

Influence of alpha-ketoglutarate on bone mineral density of the femur in piglets

100%
Kowalik S., Filip R. S., Sliwa E., Tatara M. R., Pierzynowski S. G., Studzinski T.
Bulletin of the Veterinary Institute in Puławy
|
2005
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tom 49
|
nr 3
4

Influence of alpha-ketoglutarate on cortical bone atrophy after denervation of the humerus in turkey

100%
Tatara M. R., Silmanowicz P., Majcher P., Krupski W., Studzinski T.
Bulletin of the Veterinary Institute in Puławy
|
2005
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tom 49
|
nr 1
5

Effect of simultaneous versus apart administration of dexamethasone and alpha-ketoglutarate on growth hormone, cortisol and insulin-like growth factor-I in piglets

84%
Sliwa E.
Bulletin of the Veterinary Institute in Puławy
|
2006
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tom 50
|
nr 2
6

Influence of alpha-ketoglutarate on mineral density and geometrical and mechanical parameters of femora during postnatal life in piglets

84%
Kowalik S., Sliwa E., Tatara M. R., Krupski W., Majcher P., Studzinski T.
Bulletin of the Veterinary Institute in Puławy
|
2005
|
tom 49
|
nr 1
7

Influence of alpha-ketoglutarate on cortical bone density, geometrical properties and mechanical endurance of the humerus in turkeys

84%
Tatara M. R., Majcher P., Krupski W., Pierzynowski S. G., Studzinski T.
Bulletin of the Veterinary Institute in Puławy
|
2004
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tom 48
|
nr 4
8

Effect of alpha-ketoglutarate given to pregnant sows on the development of the humerus and femur in newborns

84%
Sliwa E., Kowalik S., Tatara M. R., Krupski W., Majcher P., Luszczewska-Sierakowska I., Pierzynowski S. G., Studzinski T.
Bulletin of the Veterinary Institute in Puławy
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2005
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tom 49
|
nr 1
9

Influence of the forms of alpha-ketoglutarate as feed additive on some blood indices and performance of growing rats

67%
Filip R. S., Pierzynowski S. G.
Medycyna Weterynaryjna
|
2007
|
tom 63
|
nr 07
796-800
Alpha-ketoglutarate (AKG), a derivative of glutaminic acid and glutamate, was shown to increase muscle protein synthesis as well as to have a positive effect on the quality of bone strength. The aim of this study was to investigate the effects of AKG supplemented either as a salt (Ca + AKG) of pH 5 AKG 5, or in the pure form of pH 2 (AKG 2) on rats growth, performance, feed utilization, some blood parameters and histology of the small intestine. Sixty four rats were divided into 4 treatments and stayed on trial for 9 (n = 6) or 18 days (n = 10). The AKG 2 treated rats were observed to generally have the lowest average daily gain (ADG) with a high average daily food intake (ADFI). The only significant difference found was a reduced (P < 0.03) feed efficacy on day 9 of the AKG 2 treatment from that of the control group. All dietary treatments showed higher Hb levels than the controls on day 9, with those of dextrose and AKG 2 being significant (P < 0.03 and P < 0.005, respectively). The enterocyte crypt depth in the proximal small intestine of the AKG 2 treated rats was significantly enlarged in comparison to that of the dextrose group. From day 9 to day 18, the control as well as the dextrose and the AKG 2 treatments showed an increase in the free Gln levels, while the AKG 5 group showed a decrease in free Gln levels over time. In the AKG 2 group, the level of peptide bound (PB) Gln + Glu was higher than in controls.
10
Content available remote

Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice

67%
Niemiec T., Sikorska J., Harrison A., Szmidt M., Sawosz E., Wirth-Dzieciolowska E., Wilczak J., Pierzynowski S.
Journal of Physiology and Pharmacology
|
2011
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tom 62
|
nr 1
The objective of this study was to evaluate the effect of -ketoglutarate on redox state parameters and arterial elasticity in elderly mice. Mice in the control group were fed with standard diet, while the experimental animals received the diet supplemented either with calcium (Ca-AKG) or sodium salt of -ketoglutarate (Na-AKG). The experimental animals were divided into 4 groups with 10 individuals in each: control I (12 months old), control II (2 months old), experimental group I fed with Ca-AKG (12 months old) and experimental group II fed with Na-AKG (12 months old). Mice treated with Ca-AKG as well as the control II animals demonstrated significantly higher level of total antioxidant status (TAS), comparing to the control I animals and those treated with Ca-AKG. Thiobarbituric acid reactive substances (TBARS) level in blood plasma was found significantly lower in young and Ca-AKG treated mice. TBARS liver concentration was significantly different in each examined group. The study also demonstrates the decrease in TBARS level in Ca-AKG treated animals. Treatment with Na-AKG significantly increased glutathione peroxidase activity and decreased the activity of superoxide dismutase. The presented results suggest that Ca-AKG protects the organism against the free radicals related elderly processes. The study presents also the effect of Ca-AKG treatment on arterial elastic characteristics in elderly mice. The beneficial effect of Ca-AKG on ageing organisms was confirmed via redox state stabilization and blood vessel elasticity improvement.
11
Content available remote

Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption-metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy ageing perspective state of the art - review article

67%
Harrison A. P., Pierzynowski S. G.
Journal of Physiology and Pharmacology. Supplement
|
2008
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tom 59
|
nr 1
The fact that men and women are living longer than they have ever done before is something in which we can all rejoice. However, the process of ageing is associated with changes in skeletal, muscular, gastrointestinal, neural hormonal and metabolic processes that seriously affect an individual's performance and quality of life. Indeed, such changes can be contributory to a loss of independence in the elderly. This state-of-the art address highlights the main changes found to occur with ageing whilst simultaneously reporting findings of in vivo and in vitro studies designed to elucidate the potential of the Krebs cycle intermediate - alpha-ketoglutaric acid (AKG) in protecting elderly body systems from failing and degradation. The topics of paramount importance include impaired bone structure and strength, amino acid and mineral absorption, muscle performance, as well as highlighting the role of Krebs cycle intermediates in the debilitating changes that occur with end-stage renal failure and the regulation of the lipid metabolism. Finally, focus will be given to the role of 2-oxoglutarate as a potent protective factor in connection with the development of malignant cells in the body.
12

Changes of a non-specific defence mechanism in blood serum of piglets induced by prenatal and postnatal administration of alpha-ketoglutarate

67%
Sliwa E., Dobrowolski P., Siwicki A. K., Pierzynowski S. G.
Bulletin of the Veterinary Institute in Puławy
|
2007
|
tom 51
|
nr 2
The aim of this study was to establish the influence of α-ketoglutarate (AKG), administered to pregnant sows from the 91st d of pregnancy to farrowing, and then to piglets from birth to the 30th d of life, on lysozyme and ceruloplasmin activity, serum total protein content, and the WBC counts in blood of piglets, at the age of the 14th and 30th d of their postnatal life. The sows were treated per os with AKG at the dosage of 0.4 g/kg b.w. every day, whereas those of the controls were given saline. Piglets born by sows treated with AKG were divided into two groups: the first group was administered orally saline (AKG/PhS group) and the second group received orally AKG at the dosage of 0.4 g/kg b.w./d (AKG/AKG group), during 30 d of their postnatal life. Administration of AKG to sows during pregnancy increased lysozyme activity in piglets at the age of the 30th d, which reached the value 7.07 mg/L, while that in the controls was 3.90 mg/L. Ceruloplasmin activity decreased during the first 14 d of life in piglets that received AKG as a continuation of the prenatal procedure. At the age of 14 d, ceruloplasmin activity decreased to 90.96 IU/L in comparison with the 117.95 IU/L of the controls, while the level of total protein was higher (71.83 g/L) than that of the controls (64.23 g/L). There is still limited information about the relationship between exposure to AKG during foetal, and/or early postnatal life and altered postnatal immune function in piglets.
13

Physiological and biochemical changes induced by osmolarity in halotolerant Aspergilli

67%
Mahdy H. M., El-Sheikh H. H., Ahmed M. S., Refaat B. M.
Acta Microbiologica Polonica
|
1996
|
tom 45
|
nr 1
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