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1

The role of advanced glycation end products in various types of neurodegenerative disease: a therapeutic approach

100%
Salahuddin P., Rabbani G., Khan R. H.
Cellular and Molecular Biology Letters
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2014
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tom 19
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nr 3
Protein glycation is initiated by a nucleophilic addition reaction between the free amino group from a protein, lipid or nucleic acid and the carbonyl group of a reducing sugar. This reaction forms a reversible Schiff base, which rearranges over a period of days to produce ketoamine or Amadori products. The Amadori products undergo dehydration and rearrangements and develop a cross-link between adjacent proteins, giving rise to protein aggregation or advanced glycation end products (AGEs). A number of studies have shown that glycation induces the formation of the β-sheet structure in β-amyloid protein, α-synuclein, transthyretin (TTR), copper-zinc superoxide dismutase 1 (Cu, Zn-SOD-1), and prion protein. Aggregation of the β-sheet structure in each case creates fibrillar structures, respectively causing Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, familial amyloid polyneuropathy, and prion disease. It has been suggested that oligomeric species of glycated α-synuclein and prion are more toxic than fibrils. This review focuses on the pathway of AGE formation, the synthesis of different types of AGE, and the molecular mechanisms by which glycation causes various types of neurodegenerative disease. It discusses several new therapeutic approaches that have been applied to treat these devastating disorders, including the use of various synthetic and naturally occurring inhibitors. Modulation of the AGE-RAGE axis is now considered promising in the prevention of neurodegenerative diseases. Additionally, the review covers several defense enzymes and proteins in the human body that are important anti-glycating systems acting to prevent the development of neurodegenerative diseases.
2

The effect of packed red blood cell storage on arachidonic acid and advanced glycation end-product formation

100%
Lysenko L., Mierzchala M., Gamian A., Durek G., Kubler A., Kozlowski R., Sliwinski M.
Archivum Immunologiae et Therapiae Experimentalis
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2006
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tom 54
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nr 5
3
Content available remote

Morphometric analysis of muscle fibre types in rat locomotor and postural skeletal muscles in different stages of chronic kidney disease

84%
Flisinski M., Brymora A., Elminowska-Wenda G., Bogucka J., Walasik K., Stefanska A., Strozecki P., Manitius J.
Journal of Physiology and Pharmacology
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2014
|
tom 65
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nr 4
4

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

84%
Dzaman K., Zagor M., Molinska-Glura M., Krzeski A.
Folia Histochemica et Cytobiologica
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2015
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tom 53
|
nr 1
5

Ability of dietary alpha-tocopherol and quercetin to modulate expression of RAGE and other markers of oxidative stress induced by advanced glycation endproducts in human endothelial cells

84%
Ames J. M., Deo P., Glenn J. V., Powell L. A., Stitt A. W.
Polish Journal of Food and Nutrition Sciences
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2011
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tom 61
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nr Suppl.1
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