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L-asparaginase: An ultimate anti-neoplastic enzyme

100%

Prasad Talluri V. S. S. L., Bhavana M., Mahesh Kumar M. V. S., Rajagopal S. V.

International Letters of Natural Sciences

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2014

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tom 10

The objective of the study described the importance of L-asparaginase and its importance in the field of medicine. Different types of enzymes are produced based on the adaptation to the environment where the living organisms live to tune the metabolic pathways according to their adapted changes. The enzymes present in various organs are produced by many cell types in multicellular organisms. Except ribosomes all other known enzymes are proteinaceous in nature. L-asparaginase is a potential therapeutic agent for acute lymphoblastic leukemia (ALL) and chronic myelogenous leukemia which is approved by FDA & WHO. L-asparaginase catalyzes the deamination of L-asparagine to L-aspartic acid & ammonia. Unlike normal cells, malignant cells require large amount of L-asparagine for protein synthesis and cell division. From this background the present review is an effort to gather the information on the mechanism, sources, molecular details and application of L-asparaginase enzyme.

2

DNA aneuploidia in cells of acute leukemia non B non T type on children

100%

Krygier-Stojalowska A., Zwierzykowska A., Rakowska-Plusser M., Urasinski T., Osipowicz E., Gapski Z., Wozniak B.

Folia Histochemica et Cytobiologica

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1986

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tom 24

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nr 3

3

Correlation between hyperdiploidy 51plus of acute lymphoblastic leukemia and DNA ploidy

100%

Brycz-Witkowska J., Sikorska-Fic B., Stanczak H., Chmarzynska-Mroz E., Rybczynska J., Wasiutynski A., Rokicka-Milewska R., Wasik M.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

4

Expression of CD79a antigen in acute lymphoblastic leukaemias in children

100%

Nowicki M., Miskowiak B., Konwerska A.

Folia Histochemica et Cytobiologica

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1999

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tom 37

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nr 2

5

CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells

86%

Luczynski W., Stasiak-Barmuta A., Ilendo E., Krawczuk-Rybak M., Malinowska I., Mitura-Lesiuk M., Parfienczyk A., Szymanski M.

Acta Biochimica Polonica

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2006

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tom 53

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nr 2

Despite the very high percentage of long-term remissions in acute lymphoblastic leukemia (ALL) in children, some of them suffer from recurrence of the disease. New treatment modalities, e.g. effective geno- and immunotherapy are needed. The use of neoplasmatic cells to present tumor antigens is one of the approaches in cancer vaccines. ALL cells lack the expression of costimulatory molecules and are poor antigen presenting cells (APCs) for T-cell activation. CD40/40L interaction stimulates B-cells to proliferate, differentiate, upregulate costimulatory molecules and increase antigen presentation. The aim of the study was to test the hypothesis that ALL cells can be turned into professional APCs by CD40L activation. Children with B-cell precursor ALL were enrolled into the study. Mononuclear cells from bone marrow or peripheral blood were stimulated with CD40L and interleukin 4. Results: 1) after culture we noted upregulation of all assessed costimulatory, adhesion and activatory molecules i.e. CD1a, CD11c, CD40, CD54, CD80, CD83, CD86, CD123, HLA class I and II; 2) CD40L activated ALL cells induced proliferation of allogeneic T-cells (measured by [3H]thymidine incorporation). These results confirm the possibility of enhancing the immunogenicity of ALL cells with the CD40L system and indicate that this approach can be used in immunotherapeutic trials.

6

Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia

72%

Ploszynska A., Ruckemann-Dziurdzinska K., Jozwik A., Mikosik A., Lisowska K., Balcerska A., Witkowski J. M.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 2

7

WNT7A expression is downregulated in T lymphocytes after T-cell receptor activation due to histone modifications and in T-ALL by DNA methylation

72%

Barreto-Vargas C., Alvarez-Zavala M., Garcia-Chagollan M., Hernandez-Flores G., Aguilar-Lemarroy A., Jave-Suarez L. F.

Archivum Immunologiae et Therapiae Experimentalis

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2020

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tom 68

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nr 3

8

Clinical and In vitro studies on impact of high-dose etoposide pharmacokinetics prior allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia on the risk of post-transplant leukemia relapse

72%

Sobiak J., Kazimierczak U., Kowalczyk D. W., Chrzanowska M., Styczynski J., Wysocki M., Szpecht D., Wachowiak J.

Archivum Immunologiae et Therapiae Experimentalis

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2015

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tom 63

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nr 5

9

Upregulated miR-96-5p inhibits cell proliferation by targeting HBEGF in T-cell acute lymphoblastic leukemia cell line

72%

Xu K., Yan X., Ouyang G., Feng J., Ye L., Hu X., Liu D.

Folia Histochemica et Cytobiologica

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2020

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tom 58

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nr 3

10

Modulation of surface phenotype of acute lymphoblastic leukemia cells induced by non-specific mitogens

72%

Januszkiewicz D., Nowak J. S.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1991

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tom 39

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nr 4

11

Implementation of the standard strategy for identification of Ig-TCR targets for minimal residual disease diagnostics in B-cell precursor ALL pediatric patients: Polish experience

72%

Dawidowska M., Jolkowska J., Szczepanski T., Derwich K., Wachowiak J., Witt M.

Archivum Immunologiae et Therapiae Experimentalis

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2008

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tom 56

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nr 6

409-418

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Influence of BCR-ABL fusion proteins on the course of Ph leukemias

72%

Telegeev G. D., Dubrovska A. N., Dybkov M. V., Maliuta S. S.

Acta Biochimica Polonica

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2004

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tom 51

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nr 3

The hallmark of chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL) is the presence of the Philadelphia chromosome as a result of the t(9;22) translocation. This gene rearrangement results in the production of a novel oncoprotein, BCR/ABL, a constitutively active tyrosine kinase. There is compelling evidence that the malignant transformation by BCR/ABL is critically dependent on its Abl tyrosine kinase activity. Also the bcr part of the hybrid gene takes part in realization of the malignant phenotype. We supposed that additional mutations accumulate in this region of the BCR/ABL oncogene during the development of the malignant blast crisis in CML patients. In ALL patients having p210 fusion protein the mutations were supposed to be preexisting. Sequencing of PCR product of the BCR/ABL gene (Dbl, PH region) showed that along with single-nucleotide substitutions other mutations, mostly deletions, had occurred. In an ALL patient a deletion of the 5th exon was detected. The size of the deletions varied from 36 to 220 amino acids. For one case of blast crisis of CML changes in the character of actin organization were observed. Taking into account the functional role of these domains in the cell an etiological role of such mutations on the disease phenotype and leukemia progression is plausible.

13

Assessment of selected co-stimulatory, adhesion and activatory molecules and cytokines of Th1-Th2 balance in acute lymphoblastic leukemia in children

72%

Luczynski W., Stasiak-Barmuta A., Krawczuk-Rybak M., Malinowska I.

Archivum Immunologiae et Therapiae Experimentalis

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2005

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tom 53

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nr 4

14

Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia

72%

Brozek I., Babinska M., Kardas I., Wozniak A., Balcerska A., Hellmann A., Limon J.

Journal of Applied Genetics

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2003

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tom 44

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nr 3

15

Cytokine production in whole blood cell cultures of patients with B-lineage acute lymphoblastic leukemia. The influence of granulocyte-macrophage colony-stimulating factor

72%

Kaminska T., Hus I., Dmoszynska A., Kandefer-Szerszen M.

Archivum Immunologiae et Therapiae Experimentalis

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2001

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tom 49

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nr 1

16

In vitro response of human pathological hematopoietic cells to cladribine

58%

Mazur L., Opydo-Chanek M., Stojak M., Janota B., Blicharski K., Wojcieszek K., Klaput U., Borowicz P.

Folia Biologica

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2013

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tom 61

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nr 3-4

17

Cytotoxic activity of stigmasteryl esters and products of their thermo-oxidative degradation against drug sensitive and drug resistant human acute lymphoblastic leukemia cells

58%

Raczyk M., Paszel-Jaworska A., Rudzinska M.

Acta Scientiarum Polonorum. Technologia Alimentaria

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2018

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tom 17

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nr 1

18

The application of CAR-T cells in haematological malignancies

58%

Skorka K., Ostapinska K., Malesa A., Giannopoulos K.

Archivum Immunologiae et Therapiae Experimentalis

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2020

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tom 68

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nr 6

19

Total antioxidant status (TAS) in childhood cancer survivors

58%

Krawczuk-Rybak M., Panasiuk A., Czygier M., Muszynska-Roslan K., Wysocka J., Szmitkowski M.

Folia Histochemica et Cytobiologica

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2012

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tom 50

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nr 3

20

Relapse of acute lymphoblastic leukemia in children in the context of microarray analyses

58%

Szczepanek J., Styczynski J., Haus O., Tretyn A., Wysocki M.

Archivum Immunologiae et Therapiae Experimentalis

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2011

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tom 59

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nr 1

Ograniczanie wyników

L-asparaginase: An ultimate anti-neoplastic enzyme

DNA aneuploidia in cells of acute leukemia non B non T type on children

Correlation between hyperdiploidy 51plus of acute lymphoblastic leukemia and DNA ploidy

Expression of CD79a antigen in acute lymphoblastic leukaemias in children

CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells

Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia

WNT7A expression is downregulated in T lymphocytes after T-cell receptor activation due to histone modifications and in T-ALL by DNA methylation

Clinical and In vitro studies on impact of high-dose etoposide pharmacokinetics prior allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia on the risk of post-transplant leukemia relapse

Upregulated miR-96-5p inhibits cell proliferation by targeting HBEGF in T-cell acute lymphoblastic leukemia cell line

Modulation of surface phenotype of acute lymphoblastic leukemia cells induced by non-specific mitogens

Implementation of the standard strategy for identification of Ig-TCR targets for minimal residual disease diagnostics in B-cell precursor ALL pediatric patients: Polish experience

Influence of BCR-ABL fusion proteins on the course of Ph leukemias

Assessment of selected co-stimulatory, adhesion and activatory molecules and cytokines of Th1-Th2 balance in acute lymphoblastic leukemia in children

Cytogenetic analysis and clinical significance of chromosome 7 aberrations in acute leukaemia

Cytokine production in whole blood cell cultures of patients with B-lineage acute lymphoblastic leukemia. The influence of granulocyte-macrophage colony-stimulating factor

In vitro response of human pathological hematopoietic cells to cladribine

Cytotoxic activity of stigmasteryl esters and products of their thermo-oxidative degradation against drug sensitive and drug resistant human acute lymphoblastic leukemia cells

The application of CAR-T cells in haematological malignancies

Total antioxidant status (TAS) in childhood cancer survivors

Relapse of acute lymphoblastic leukemia in children in the context of microarray analyses