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Mechanisms of vascular dysfunction after subarachnoid hemorrhage

100%

Kozniewska E., Michalik R., Rafalowska J., Gadamski R., Walski M., Frontczak-Baniewicz M., Piotrowski P., Czernicki Z.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 11

145-160

The main consequence of subarachnoid hemorrhage, for those who survive bleeding, is delayed, persistent vasospasm of intracranial conduit arteries which occurs between the third and seventh day after the insult and results in symptomatic brain ischemia in about 40% of cases. This vasospasm is considered to be a major cause of disability of post-SAH patients. Despite extensive experimental and clinical research, mechanisms of vasospasm are not fully understood. Dysfunction of the endothelium resulting in enhanced production of vasoconstrictors, phenotypic changes of the receptors in endothelium and smooth muscle cells, increased sensitivity of vascular smooth muscle cells to vasoconstrictors, release of spasmogens from lysed blood clot and inflammatory response of the vascular wall have been demonstrated and discussed as pathological mechanisms participating in the development of spasm. In recent years more attention is paid to the functional and structural changes in microcirculation and a concept of microvascular spasm is evolving. Our experimental studies in rat model of SAH strongly suggest that microcirculatory dysfunction and delayed vasospasm are related to the severity of acute, transient ischemia caused by critical decrease of perfusion pressure and active vasoconstriction immediately after the bleeding.

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Acute ischemic stroke within the area of MCA from ICA thrombosis complicating moderate COVID-19 infection

100%

Kurys-Denis E., Prystupa A., Sak J.

Journal of Pre-Clinical and Clinical Research

2021

tom 15

nr 1

Influence of bradykinin on the course of ischemia-reperfusion syndrome

80%

Krauss H., Biczysko W., Majewski P., Grzymislawski M., Sosnowski P., Kozlik J., Jablecka A., Bednarek A., Balcer N.

Medycyna Weterynaryjna

2007

tom 63

nr 08

914-918

Acute ischemia and the subsequent reperfusion caused by temporary closure of blood flow in the main arteries, which activate generalized inflammatory response, lead to endothelial injury. The aim of the study was to examine the injury of tissues in the ischemia reperfusion syndrome. Additionally, we tried to estimate the role of B1 and B2 bradykinin-receptor antagonists. In our study we histologically assessed specimens of lungs, kidney, liver, small and large intestine and skeletal muscle from the thigh. We compared the samples obtained from the groups of animals that were exposed to 4 hours of complete ischemia and 120 minutes of reperfusion. We divided animals into 4 groups. Rats in the first group were the control group, animals from the second received bradykinin. In the third and fourth group respectively bradykinin along with B2 and B1 bradykinin-receptor antagonist were administered. The results of microscopic examination revealed that bradykinin exerts a protective effect on the function and structure of distant organs as well as the skeletal muscle which was subjected to ischemia and reperfusion. The most visible effects of bradykinin were found in the samples of the lung, skeletal muscle, and the large and small intestines. Administration of bradykinin receptor antagonists, especially B2 receptor blocker, reduces the advantageous effects of bradykinin. The conclusion of our study is that administration of bradykinin may be beneficial in diseases accompanied by limb ischemia where tissue blood flow and oxygen metabolism are dependent upon kinin release, which in turn will condition tissue repair.

Ograniczanie wyników

1 Journal of Physiology and Pharmacology. Supplement

1 Journal of Pre-Clinical and Clinical Research

1 Medycyna Weterynaryjna

1 Balcer N.

1 Bednarek A.

1 Biczysko W.

1 Czernicki Z.

1 Frontczak-Baniewicz M.

1 Gadamski R.

1 Grzymislawski M.

1 Jablecka A.

1 Kozlik J.

1 Kozniewska E.

1 Krauss H.

1 Kurys-Denis E.

1 Majewski P.

1 Michalik R.

1 Piotrowski P.

1 Prystupa A.

1 Rafalowska J.

1 Sak J.

1 Sosnowski P.

1 Walski M.

1 2021

1 2007

1 2006

Wyniki wyszukiwania

Mechanisms of vascular dysfunction after subarachnoid hemorrhage

Acute ischemic stroke within the area of MCA from ICA thrombosis complicating moderate COVID-19 infection

Influence of bradykinin on the course of ischemia-reperfusion syndrome