Wyniki wyszukiwania - AGRO

1

Changes in selected Wistar rat's lymph node after intratissue injection of allogeneic blood

100%

Czernicki K., Kaskosz A., Krotki W., Slusarczyk K.

Folia Morphologica

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1996

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tom 55

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nr 4

2

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Distribution of selenium in rats after repeated administration of sodium selenite

100%

Grosicki A., Kowalski B.

Bulletin of the Veterinary Institute in Puławy

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2001

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tom 45

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nr 1

The experiment involved Wistar rats given orally trace daily doses of selenium-75 for four weeks. The distribution of selenium-75 was evaluated in the carcass and selected organs within 28 days after the last administration. The results were compared with those reported in the literature; the kinetic data provided evidence that the absorption and distribution of selenium depend on several factors involving dosage and the route and period of administration.

3

Effects of post-weaning social isolation and environmental enrichment on exploratory behavior and anxiety in Wistar rats

86%

Tanas L., Ostaszewski P., Iwan A.

Acta Neurobiologiae Experimentalis

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2015

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tom 75

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nr 1

Adverse early experience is generally regarded as a risk factor for both externalizing and internalizing behavioral disorders in humans. It can be modeled in rats by a post-weaning social isolation procedure. Effects of social isolation might possibly be ameliorated by environmental enrichment. In the current study, 24 male Wistar rats were divided post-weaning into four rearing conditions: control, environmental enrichment (EE), social isolation (SI) and a combination of the two experimental conditions; (EE+SI). Two observations of the effects of rearing conditions on the rate of social and object interactions were conducted during the juvenile and post-pubertal stages of development. The SI condition led to a marked increase of social interactions during the juvenile phase, but did not affect object interactions. The EE condition increased the level of social interactions during both the juvenile and post-pubertal measurements. The effects of early rearing conditions on adult exploratory behavior were less clear, with a significant difference between the groups obtained in one of three behavioral tests. Results suggest a general robustness in the development of adult exploratory behavior and anxiety when rats were exposed to early social isolation and provided brief opportunities for social play during the juvenile period. Further studies, aimed at distinguishing play-related protective factors serving against long-term adverse effects of juvenile social isolation, are suggested.

4

Pterygopalatine ganglion in rat. I. Cytoarchitectonics of the ganglion

86%

Kuder T.

Folia Morphologica

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1990

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tom 49

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nr 1-2

5

Experimental models of cyclosporine A nephrotoxicity

86%

Korolczuk A., Maciejewski M., Czechowska G., Celinski K., Korobowicz E.

Bulletin of the Veterinary Institute in Puławy

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2010

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tom 54

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nr 1

59-62

The aim of this study was to compare the most commonly-used experimental models and to assess the microscopic renal changes in different models of cyclosporine A (CsA) nephrotoxicity. Wistar male rats were divided into five groups, eight animals in each. CsA was given in doses of 15 mg/kg, 25 mg/kg, and 100 mg/kg, respectively. The blood was collected for creatinine, urea, and uric acid levels analysis in the serum and the kidneys were sampled for microscopic examination on the 11th and 29th d of the experiment. CsA induced nephrotoxicity was characterised by increased serum levels of creatinine, urea, and uric acid. Microscopic features of CsA nephrotoxicity in all CsA experimental groups were observed. We would recommend the use of low doses of CsA for approximately 28 d as the most relevant experimental procedure for achieving the features of chronic CsA nephrotoxicity.

6

Structure of the intramedullary vascular net of the spinal cord in Wistar rats

86%

Karmanski A., Mikusek J., Karmanska W.

Folia Morphologica

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1996

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tom 55

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nr 3

7

Structure of the multiorgan renal lymph node after blockade of its afferent lymphatics from kidney in the Wistar rats

86%

Marniok B., Slusarczyk K., Ciszek M., Mikusek J.

Folia Morphologica

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1995

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tom 54

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nr 3

8

Variability of the renal lymph nodes in Wistar rats

86%

Marniok B., Mikusek J., Slusarczyk K., Ciszek M.

Folia Morphologica

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1994

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tom 53

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nr 4

9

Lipid peroxidation in liver and kidneys of rats intoxicated with vanadium and-or zinc

86%

Zaporowska H., Scibior A., Matysiak J.

Acta Poloniae Toxicologica

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1999

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tom 07

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nr 2

10

Structure of the multiorgan renal lymph node after selective blockade of its afferent lymphatics from female reproductive organs in the Wistar rats

86%

Marniok B., Mikusek J., Slusarczyk K., Ciszek M., Machelska J.

Folia Morphologica

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1995

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tom 54

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nr 2

11

Effect of quercetin on the development of aberrant crypts induced by 1,2-dimethylhydrazine in rat colon

86%

Czeczot H., Podsiad M., Skrzycki M.

Acta Poloniae Toxicologica

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2001

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tom 09

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nr 1

12

External veins of the spinal cord in the Wistar rats

86%

Karmanski A., Mikusek J., Karmanska W., Lopata P.

Folia Morphologica

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1995

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tom 54

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nr 4

13

The influence of doxycycline on articular cartilage in experimental osteoarthrosis induced by iodoacetate

86%

Cylwik J., Kita K., Barwijuk-Machala M., Reszec J., Klimiuk P., Sierakowski S., Sulkowski S.

Folia Morphologica

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2004

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tom 63

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nr 2

The experiment was performed on 36 Wistar rats. On the first day of the experiment iodoacetate was administered to the left posterior knee joint of the 18 rats which composed Group I. The second group of 18 rats received additionally doxycycline (doxy) through the gastric tube in doses comparable with those of doxycycline used in humans. The experiment lasted 21 days. The animals were sacrificed after 7, 14 and 21 days in groups of 6 rats each. In sections stained with Safranin 0 semiquantitative histochemical intensity tests were performed on articular cartilage glycosaminoglycans (GAG) using a four-point scale (0–3). In the first group examined destructive lesions in the articular cartilage and weak reactivity on GAG were noted at all stages of the experiment. The intensity of GAG staining was higher in the second group after 14 and especially after 21 days, which may suggest a protective action of doxy on articular cartilage.

14

Thymic dendritic cell-thymocyte complexes: ultrastructural cell phenotype analysis

86%

Brelinska R.

Folia Histochemica et Cytobiologica. Supplement

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1997

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tom 35

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nr 2

15

Arterial blood supply of the thoracic and lumbosacral parts of the spinal cord in Wistar rats

86%

Mikusek J., Karmanski A., Karmanska W.

Folia Morphologica

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1997

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tom 56

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nr 3

16

Morphology of the abdominal hemolymph nodes in the Wistar rats

86%

Marniok B., Mikusek J., Rudnicki P.

Folia Morphologica

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1997

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tom 56

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nr 4

17

Evaluation of the combined effect of cadmium, benzo[a]pyrene and pyrene in general toxicity studies on Wistar rats

72%

Paltanaviciene A., Zabulyte D., Kalibatas J., Uleckiene S.

Medycyna Weterynaryjna

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2007

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tom 63

|

nr 01

51-55

Heavy metal cadmium (Cd) and polycyclic aromatic hydrocarbons benzo(a)pyrene (B(a)P) and pyrene (P) are ubiquitous and persistent environmental pollutants. Human beings are constantly exposed to mixtures of these substances. Exposure to Cd may cause changes in critical organs kidneys and liver. B(a)P has an adverse effect on haemopoesis, digestive systems and on the liver. According to some data Cd, B(a)P and P may interact in all the metabolism phases of xenobiotics. The objective of our study was to investigate the combined effect of Cd, B(a)P and P on general toxicity of the organism of Wistar rats. Tests were conducted on the basis of the methodical recommendations: 407 and 408 of the OECD Guidelines for the Testing of Chemicals. In the experiment, 176 male Wistar-line rats were employed. Four different dose levels were used: 0.1, 0.5, 1.92, 4.0 mg/kg for Cd; 0.00015, 0.0015, 33.3, 10.0 mg/kg for B(a)P and 0.00075, 0.0075, 90.0, 20.0 mg/kg for P and their 4 combinations. The complex of substances studied induced changes in the biochemical blood, urinalysis, hematological parameters which indicated renal and liver function damage and evoked leukopenia symptoms. Evaluating the complex of the substances by these parameters it was noted that the combined action of substances had three types: antagonistic - 56.9%, additive - 27.4% and unknown origin - 15.7%.

18

Role of vitamin E in prevention of damages in the thymus induced by electromagnetic field: ultrastructural and light microscopic studies

72%

Mohammadnejad D., Rad J., Azami A., Lotfi A.

Bulletin of the Veterinary Institute in Puławy

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2011

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tom 55

|

nr 1

Twenty-four male Wistar rats were selected and divided into three groups (control, test group 1, test group 2). The test group 1 was exposed to EMF (50 Hz, 3 mT) 8 h a day, 6 d per week for 2 months. Test group 2 was exposed to EMF (50 Hz, 3 mT) 8 h a day, 6 d per week for 2 months but received orally 30 mg of vitamin E/d. Rats in the control group neither were exposed to electromagnetic field nor received vitamin E. At the end of the experiment, the rats were sacrificed, dissected, and samples from the thymus were taken and processed for light and electron microscopic studies. Forty microscopic fields from each group were randomly selected and studied. The data showed that in the thymus of test group 1, the population of cells in the cortex was decreased but the number of macrophages was increased. EM study showed that cellular nuclei were heterochromatic in comparison to control group. Test group 2 was similar to the control group. These findings indicate that immune system is weakened by electromagnetic field but vitamin E supplementation prevented above alteration.

19

The antiviral drug ribavirin reversibly affects the reproductive parameters in the male Wistar rat

72%

Narayana K., D'Souza U. J. A., Narayan P., Kumar G.

Folia Morphologica

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2005

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tom 64

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nr 2

65-71

The present study was planned to evaluate the toxic effects of ribavirin on the reproductive parameters in the male Wistar rat. Rats (11–13 weeks old) were treated with 5 injections (i.p.) of 20, 100 or 200 mg/kg/day ribavirin at intervals of 24 h. The testes were processed for histopathological analysis on days 14, 35, 70 and 105 after the last exposure. The parameters studied were body weight, the weights of the testis, epididymis, seminal vesicle and prostate, seminiferous tubular diameter (STD), epithelial height (SE), epithelial sloughing, incidence of stage XIV tubules, sperm abnormality and total serum level of testosterone. Data were analysed by ANOVA and the Bonferroni post hoc test for significances between different groups. There was a decrease in body weight and organ weights, excluding those of the testis and epididymis, against control at higher dose-levels. Ribavirin induced the formation of vacuoles, gaps and sloughing of the seminiferous epithelium. The STD, SE and the incidences of stage XIV tubules decreased on days 14 and 35. Ribavirin also induced the formation of sperm with microcephaly and cephalocaudal junction defects, with or without fibrils jetting out. All these morphological defects recovered to control limit by day 105. The serum level of testosterone was decreased at all dose-levels and time points, although recovery had started by day 105. In conclusion, ribavirin is gonadotoxic in male rats but the effects are reversible after a period of 105 days. However, the endocrine-disrupting properties of ribavirin persist beyond this period.

20

Some biochemical changes associated with fenarimol-induced liver growth in the rat

72%

Palut D.

Roczniki Państwowego Zakładu Higieny

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1991

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tom 42

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nr 3

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