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An analysis of PPARGC1A gene polymorphism in relation to carcass quality in PIC hybrid fatteners

100%

Polasik D., Glodek A., Rybarczyk A.

Acta Scientiarum Polonorum. Zootechnica

2013

tom 12

nr 4

The aim of this study was to determine the association between polymorphism located in exon 8 of PPARGC1A gene (Cys430Ser) and carcass quality in pigs. Experiment was carried out on 350 PIC hybrid fatteners. Polymorphism was analyzed using PCR-RFLP method. The frequency of genotypes was as follows: AA – 0.33, AT – 0.57, TT – 0.1, however alleles: A – 0.62, T – 0.38. In the analyzed population loss of Hardy-Weinberg equilibrium was observed (P ≤ 0.01). Statistical analysis showed that only one of the evaluated traits was associated with individual PPARGC1A genotypes. Cooling loss value for pig carcasses with TT genotype was statistically significant (P ≤ 0.05) higher than observed in those with AA and AT genotypes.

Analysis of the PPARGC1A gene as a potential marker for productive and reproductive traits in cattle

84%

Komisarek J., Walendowska A.

Folia Biologica

2012

tom 60

nr 3-4

SNPs in the porcine PPARGC1A gene: interbreed differences and their phenotypic effects

84%

Stachowiak M., Szydlowski M., Cieslak J., Switonski M.

Cellular and Molecular Biology Letters

2007

tom 12

nr 2

Due to its function, the peroxisome proliferative activated receptor-γ, coactivator-1α (PPARGC1A) gene is a candidate in the search for genes that may affect production traits in the pig. The purpose of this study was to screen for new SNPs in exon 8 of the porcine PPARGC1A gene and to test their possible association with production traits. Altogether 736 pigs representing five breeds Polish Landrace, n=242; Polish Large White, n=192; Hampshire, n=27; Duroc, 21; Pietrain, n=12) and synthetic line 990 (n=242) were scanned via SSCP assay. Four SNPs were found; two new ones: C/G (His338Gln) and G/A Thr359Thr), and two previously reported ones: C/A (Arg369Arg) and T/A Cys430Ser). The missense T/A and C/G SNPs demonstrated pronounced interbreed variability in terms of allele frequencies, including the exclusive presence of the C/G substitution in the Hampshire breed. The tested SNPs occurred in five putative haplotypes, and their frequency also differed substantially between breeds. The association of the SNPs with production traits was tested for G/A (Thr359Thr), C/A (Arg369Arg) and T/A (Cys430Ser) substitutions in Polish Large White, Polish Landrace and line 990. The analysis revealed only breed-specific associations. The T/A (Cys430Ser) SNP was related to the feed conversion ratio in the Polish Large White (P=0.02), and the silent G/A and C/A substitutions were respectively associated with abdominal fat in line 990 and backfat thickness in Polish Landrace (P=0.04). The combined effects of the substitutions were estimated as haplotype effects. Three significant contrasts between haplotypes were calculated, but the observed associations were again only breed-specific.

Ograniczanie wyników

1 Acta Scientiarum Polonorum. Zootechnica

1 Cellular and Molecular Biology Letters

1 Folia Biologica

1 Cieslak J.

1 Glodek A.

1 Komisarek J.

1 Polasik D.

1 Rybarczyk A.

1 Stachowiak M.

1 Switonski M.

1 Szydlowski M.

1 Walendowska A.

1 2013

1 2012

1 2007

Wyniki wyszukiwania

An analysis of PPARGC1A gene polymorphism in relation to carcass quality in PIC hybrid fatteners

Analysis of the PPARGC1A gene as a potential marker for productive and reproductive traits in cattle

SNPs in the porcine PPARGC1A gene: interbreed differences and their phenotypic effects