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1
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Szczepy Candida albicans, Candida aqatica, Candida krusei i Candida tropicalis izolowane ze zrodel wojewodztwa podlaskiego

100%
Kiziewicz B.
Wiadomości Parazytologiczne
|
2004
|
tom 50
|
nr 3
535-544
2
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Enzymatic activity of yeasts isolated from the inflamed mammary secretion in dairy cows

100%
Wawron W., Bochniarz M., Szczubial M.
Polish Journal of Veterinary Sciences
|
2011
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tom 14
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nr 1
The aim of the study was to evaluate enzymatic activities of yeasts isolated from inflammatory mammary secretion. The yeasts isolated from cows with clinical and sub-clinical mastitis (134 strains) included: Candida krusei (62 strains), Candida kefyr (48 strains), Candida lusitaniae (17 strains) and Candida famata (7 strains). The API ZYM system was used containing substrates to assess 19 hydrolytic enzymes. Substantial differences in the number and activity of hydrolyses were demonstrated in individual species. In Candida krusei, acid phosphatase showed the highest activity (4.36 points), in Candida kefyr and Candida lusitaniae – leucine arylamidase (4.93 and 4.25 points, respectively), in Candida famata – α-glucosidase (4.75 points). No activity of trypsin, chymotrypsin, α-galactosidase, β-glucuronidase, α-mannosidase or α-fucosidase was observed in any of the yeasts examined.
3
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Biometrical analysis of vegetative cells of C.albicans, C.glabrata, C.humicola, C.krusei and C.tropicalis

100%
Kurnatowska A., Danilewicz M.
Wiadomości Parazytologiczne
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1998
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tom 44
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nr 3
4

Antifungal activity of thionated analogues of Nva-FMDP and Lys-Nva-FMDP

80%
Nowak-Jary J., Andruszkiewicz R.
Polish Journal of Microbiology
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2009
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tom 58
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nr 4
295-299
The antifungal activity of synthetic endothiopeptdides, i.e. NvaΨ [CSNH]-FMDP and LysΨ [CSNH]-NvaΨ [CSNH]-FMDP was studied in medium containing blood serum, against selected Candida strains; Candida albicans Gu4 (fluconazole sensitive), C. albicans Gu5 (fluconazole resistant), C. albicans ATCC 10231, Candida krusei DSM 6128 and Candidaparapsilosis DSM 5784. Although thiopeptide bonds in the tested peptides increased their stability in blood serum, their antifungal activity, however, drastically decreased in comparison with the peptides containing non-modified peptide bonds. Moreover, the inhibitory activity towards glucosamine-6-phosphate synthase of thionated synthetic analogue of FMDP was performed. The thiopeptdide bond also influenced its inhibitory properties against enzyme from C. albicans.
5

Przyleganie grzybow z rodzaju Candida do komorek ssakow

80%
Macura A. B.
Postępy Mikrobiologii
|
1993
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tom 32
|
nr 4
321-336
6

Antifungal activity of some model Soft lysosomotropic compounds

80%
Bien M., Lachowicz T. M., Sauter E., Luczynski J., Witek S.
Bulletin of the Polish Academy of Sciences. Biological Sciences
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1995
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tom 43
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nr 2
7

Mechanisms of resistance to azole antifungals

80%
Marichal P., Bossche H. V.
Acta Biochimica Polonica
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1995
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tom 42
|
nr 4
Until the late eighties, clinical resistance to azole antifungals was a rare pheno­menon. Only a few cases of resistance to ketoconazole were found in patients with chronic mucocutaneous candidiasis (CMC). The spread of AIDS and the widespread prophylactic and therapeutic use of the hydrophilic azole compound fluconazole resulted both in the selection and induction of resistant strains and in a shift in the nature of the infecting organisms. Most azole antifungals such as itraconazole, ketoconazole and fluconazole are active against a variety of fungal diseases. However, the concentration needed to inhibit growth is dependent on the nature of the infecting species. Mucor spp., e.g., are almost insensitive to present available azole compounds and can be regarded as intrinsically resistant to azole treatment. Physicochemical features, such as the hydrophobicity and pKa, of a given azole, define whether or not it will be active or cross-resistant against a given species. Fluconazole is almost inactive against Candida krusei and Aspergillus fumigatus, whereas the lipophilic itraconazole is active against these species. A third type of resistance is acquired or induced resistance. This is the most contro­versial type because, even within a given species, organisms may differ in their response to the same azole. For these strains, convincing evidence can only be obtained when there is a genotypically related strain, which does not show resistance. In a limited number of biochemical or molecular biological studies the mechanisms of resistance have been investigated at the molecular level. These studies show that resistance can occur when there is an insufficient intracellular content of the azole. This can be due to impermeability problems, inactivated uptake systems or, and more likely, the presence of active multidrug resistance gene products of the P-glycoprotein type. Alteration or overexpression of the target for azole antifungals, the cytochrome P450-dependent 14 a-demethylase, also induces resistance. The nature and amount of the accumulating sterols also are of great importance for azole-induced growth inhi­bition. This may explain why mutations in other enzymes of the ergosterol bio­synthesis pathway, e.g. the A5-6 desaturase, can contribute to azole resistance.
8

Killer activity of yeasts isolated from natural environments against some medically important Candida species

80%
Vadkertiova R., Slavikova E.
Polish Journal of Microbiology
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2007
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tom 56
|
nr 1
Twenty-five yeast cultures, mainly of human origin, belonging to four pathogenic yeast species - Candida albicans, Candida krvsei, Candida parapsilosis, and Candida tropicalis were tested for their sensitivity to ten basidiomycetous and eleven ascomycetous yeast species isolated from the water and soil environments and from tree leaves. The best killer activity among basidiomycetous species was exhibited by Rhodotorula glutinis, and R. mucilaginosa. The other carotenoid producing species Cystofdobasidium capitatum, Sporobolomyces salmonicolor, and S. roseus were active only against about 40% of the tested strains and exhibited weak activity. The broadest killer activity among ascomycetous yeasts was shown by the strains Pichia anomala and Metschnikowiapulcherrima. The species Debaryomyces castellii, Debaryomyces hansenii, Hanseniaspora guilliermondii, Pichia membranifaciens, and Williopsis californica did not show any killer activity. The best killer activity exhibited the strains isolated from leafy material. The lowest activity pattern was found among strains originating from soil environment.
9

Dzialanie in vitro bakterii z rodzaju Lactobacillus izolowanych z pochwy na grzyby wywolujace kandydoze sromu i pochwy

71%
Strus M., Brzychczy-Wloch M., Kucharska A., Gosiewski T., Heczko P. B.
Medycyna Doświadczalna i Mikrobiologia
|
2005
|
tom 57
|
nr 1
7-17
Bakterie Lactobacillus delbrueckii, występujące w mikroflorze pochwy wspólnie z gatunkami z grupy Lactobacillus acidophilus, hamują wzrost Candida albicans w czasie 90 minut, zaś bakterie z gatunku Lactobacillus plantarum - po 24 godzinach. Wczesne działanie Lactobacillus można przypisać nadtlenkowi wodoru, zaś późne - innym metabolitom. W warunkach naturalnych bakterie z rodzaju Lactobacillus prawdopodobnie współdziałają ze sobą przeciwko C. albicans, wykorzystując kilka metabolitów.
10
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Antimicrobial activity of chlorophyll and methanol extract of Lannea coromandelica Merr.

61%
Vedhanarayanan P., Vaithiyanathan T., Sundaramoorthy P.
International Letters of Natural Sciences
|
2015
|
tom 45
The antimicrobial activity of chloroform and methanol extracts of Lennea coromandelica were screened for their was studied against gram positive bacteria strains Staphylococcus aureus, Streptococcus pyogenes and Bacillus subtilis gram negative bacteria strains Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli and fungal strains such as Candida albicans, C. parapsilosis, C. krusei and C. glabrata using disc diffusion method, determination of Minimum Inhibitory Concentrations (MIC), Minimum Bacterial Concentrations (MBC) and Minimum Fungicidal Concentrations (MFC). The antimicrobial activity for different concentrations like 250 μg, 500 μg and 1000 μg of different solvent extracts of Lannea cormandelica. bacterial strains and recorded in highest mean zones of inhibition ranged from 19.6 mm and Candidal strains and the exhibited the highest mean zones of inhibition ranged from 10.6 mm. Methanol extracts showed the best results as inhibition zones against tested organisms. Results showed also that, the greatest effect was towards Staphylococcus aureus and the lowest was against Candida krusei. The present study reported the great effect of Lannea cormandelica extracts against some of most important pathogens.
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