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1

Repeat region of Brugia malayi sheath protein (Shp-1) carries Dominant B epitopes recognized in filarial endemic population

100%
Jawaharlal J. P. P., Madhumathi J., Prince R. P., Kaliraj P.
Acta Parasitologica
|
2014
|
tom 59
|
nr 3
Transmission of lymphatic filariasis is mediated through microfilariae (L1 stage of the parasite) which is encased in an eggshell called sheath. The sheath protein Shp-1 stabilizes the structure due to the unique repeat region with Met-Pro-Pro-Gln-Gly sequences. Microfilarial proteins could be used as transmission blocking vaccines. Since the repeat region of Shp-1 was predicted to carry putative B epitopes, this region was used to analyze its reactivity with clinical samples towards construction of peptide vaccine. In silico analysis of Shp-1 showed the presence of B epitopes in the region 49–107. The polypeptide epitopic region Shp-149–107 was cloned and expressed in Escherichia coli. Antibody reactivity of the Shp-149–107 construct was evaluated in filarial endemic population by ELISA. Putatively immune endemic normals (EN) showed significantly high reactivity (P < 0.05) when compared to all the other categories. Antibody reactivity of Shp-1 repeat region was similar to that of whole protein proving that this region carries B epitopes responsible for its humoral response in humans. Thus this can be employed for inducing anti-microfilarial immunity in the infected population that may lead to reduction in transmission intensity and also it could be used along with other epitopes from different stages of the parasite in order to manage the disease effectively.
2

Immunolocalization of disorganized muscle protein-1 in different life stages of human lymphatic flariid, Brugia malayi

100%
Kushwaha V., Sahasrabuddhe A. A., Murthy P. K.
Acta Parasitologica
|
2020
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tom 65
|
nr 4
3

Role of glutathione in chalcone derivative induced apoptosis of Brugia malayi and its possible therapeutic implication

100%
Bhoj P. S., Bahekar S., Khatri V., Singh N., Togre N. S., Goswami K., Chandak H. S., Dash D.
Acta Parasitologica
|
2021
|
tom 66
|
nr 2
4

Brugia malayi in Mastomys natalensis: exposure during pregnancy and lactation

100%
Tyagi K., Murthy P. K., Chatterjee R. K.
Acta Parasitologica
|
1994
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tom 39
|
nr 3
5

Immune responses of B. malayi thioredoxin (TRX) and venom allergen homologue (VAH) chimeric multiple antigen for lymphatic filariasis

84%
Anugraha G., Jeyaprita P. J., Madhumathi J., Sheeba T., Kaliraj P.
Acta Parasitologica
|
2013
|
tom 58
|
nr 4
Although multiple vaccine strategy for lymphatic filariasis has provided tremendous hope, the choice of antigens used in combination has determined its success in the previous studies. Multiple antigens comprising key vaccine candidates from different life cycle stages would provide a promising strategy if the antigenic combination is chosen by careful screening. In order to analyze one such combination, we have used a chimeric construct carrying the well studied B. malayi antigens thioredoxin (BmTRX) and venom allergen homologue (BmVAH) as a fusion protein (TV) and evaluated its immune responses in mice model. The efficacy of fusion protein vaccine was explored in comparison with the single antigen vaccines and their cocktail. In mice, TV induced significantly high antibody titer of 1,28,000 compared to cocktail vaccine TRX+VAH (50,000) and single antigen vaccine TRX (16,000) or VAH (50,000). Furthermore, TV elicited higher level of cellular proliferative response together with elevated levels of IFN-γ, IL-4 and IL-5 indicating a Th1/Th2 balanced response. The isotype antibody profile showed significantly high level of IgG1 and IgG2b confirming the balanced response elicited by TV. Immunization with TV antigen induced high levels of both humoral and cellular immune responses compared to either cocktail or antigen given alone. The result suggests that TV is highly immunogenic in mice and hence the combination needs to be evaluated for its prophylactic potential.
6

In search of a potential diagnostic tool for molecular characterization of lymphatic filariasis

84%
Saeed M., Adnan M., Khan S., Al-Shammari E., Mustafa H.
Acta Parasitologica
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2016
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tom 61
|
nr 1
7
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Vectors of lymphatic filariasis of human

67%
Okulewicz A., Fronska-Popiel A.
Wiadomości Parazytologiczne
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1999
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tom 45
|
nr 4
8

Filariozy zwierząt i ludzi

51%
Soltysiak Z., Frydrychowski P., Noszczyk-Nowak A.
Magazyn Weterynaryjny. Zeszyt Edukacyjny
|
2017
|
nr 6. Parazytologia psów i kotów
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