Wyniki wyszukiwania

1

Altered serum levels of autophagy proteins Beclin-1 and mTOR in patients with exudative age-related macular degeneration

100%

Kubicka-Trzaska A., Zuber-Laskawiec K., Plutecka H., Romanowska-Dixon B., Sanak M., Kraska-Basta I.

Journal of Physiology and Pharmacology

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2021

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tom 72

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nr 1

2

Beclin-1 and its role as a target for anticancer therapy

86%

Toton E., Lisiak N., Sawicka P., Rybczynska M.

Journal of Physiology and Pharmacology

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2014

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tom 65

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nr 4

3

MicroRNA-21 ameliorates the impairment of autophagy in palatal wound healing

72%

Ma R., Li X., Tewari N., Liu Y., Bhawal U. K., Zeng X.

Journal of Physiology and Pharmacology

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2020

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tom 71

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nr 6

4

Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin

72%

Lamparska-Przybysz M., Gajkowska B., Motyl T.

Journal of Physiology and Pharmacology. Supplement

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2005

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tom 56

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nr 3

159-179

The details of molecular switching points between apoptosis and autophagy in tumor cells have still not been fully elucidated. This study focused on the role of cathepsin B and its substrate, BID as molecular links between apoptosis and autophagy in human breast cancer MCF-7 cells exposed to camptothecin. Apoptosis occurred rapidly with a peak in 60 min after drug administration, whereas autophagy developed at a much slower rate with continuous progression during 24 h of cell exposure to the drug. CPT induced very rapid activation of cathepsin B. Inhibition of cathepsins by E64d prevented CPT-induced BAX and BID aggregation on mitochondria and reduced significantly reduced apoptotic cell number. The above effects were accompanied by an increase in autophagosome formation, measured by expression of MAP I LC3. BID knock down resulted in strong suppression of CPT-induced apoptosis and a shift of cell death towards autophagy, manifesting with an increase of Beclin 1 and MAP I LC3 cellular content.

5

Beclin 1 is involved in regulation of apoptosis and autophagy during replication of ectromelia virus in permissive L929 cells

58%

Martyniszyn L., Szulc L., Boratynska A., Niemialtowski M. G.

Archivum Immunologiae et Therapiae Experimentalis

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2011

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tom 59

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nr 6

Ograniczanie wyników

3 Journal of Physiology and Pharmacology

1 Archivum Immunologiae et Therapiae Experimentalis

1 Journal of Physiology and Pharmacology. Supplement

1 Bhawal U. K.

1 Boratynska A.

1 Gajkowska B.

1 Kraska-Basta I.

1 Kubicka-Trzaska A.

1 Lamparska-Przybysz M.

1 Li X.

1 Lisiak N.

1 Liu Y.

1 Ma R.

1 Martyniszyn L.

1 Motyl T.

1 Niemialtowski M. G.

1 Plutecka H.

1 Romanowska-Dixon B.

1 Rybczynska M.

1 Sanak M.

1 Sawicka P.

1 Szulc L.

1 Tewari N.

1 Toton E.

1 Zeng X.

1 Zuber-Laskawiec K.

1 2021

1 2020

1 2014

1 2011

1 2005

Altered serum levels of autophagy proteins Beclin-1 and mTOR in patients with exudative age-related macular degeneration

Beclin-1 and its role as a target for anticancer therapy

MicroRNA-21 ameliorates the impairment of autophagy in palatal wound healing

Cathepsins and BID are involved in the molecular switch between apoptosis and autophagy in breast cancer MCF-7 cells exposed to camptothecin

Beclin 1 is involved in regulation of apoptosis and autophagy during replication of ectromelia virus in permissive L929 cells