Wyniki wyszukiwania

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Apoptosis monitoring in human acute leukaemia cells stimulated by Bcl-2 antisense oligonucleotide and BAY K 8644

100%

Kocki J., Kocki T., Lancut M., Bogucka-Kocka A., Cioch M., Dmoszynska A., Wojcierowski J.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr Suppl.2, Part 1

In this study we investigated effects of bcl-2 antisense oligonucleotides (AS) and BAY K 8644 (B), calcium channel agonist, on human leukaemic cells from non-treatment patients with acute myeloblastic leukaemias. Apoptotic cells were observed in electron and fluorescent microscopes. When we examined the effects of AS + B on cells, level of bcl-2 mRNA decreased more as in cells stimulated by AS only. These observations indicate that AS with B in human leukaemic cells disturb cell viability by inducing apoptosis.

2

Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture

80%

Kaszuba-Zwoinska J., Chorobik P., Juszczak K., Zaraska W., Thor P. J.

Journal of Physiology and Pharmacology

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2012

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tom 63

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nr 5

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A comparison of Bcl-2 expression, microvessel density and color Doppler sonography in the benign and malignant ovarian tumors

80%

Czekierdowska S., Rolinski J., Czekierdowski A., Bednarek W., Szumilo J., Kotarski J.

Polish Journal of Environmental Studies

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2004

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tom 13

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nr Suppl.2, Part 1

To compare Color Doppler sonography with immunohistochemical microvessel density and Bcl-2 assessement in women with benign and malignant adnexal tumors we examined 112 women with adnexal tumors with the use color Doppler sonography (B&K 2002 ADI and GE Voluson 730 scanners) performed before the surgical procedure. Histological type, grading, FIGO stage and menopausal status were compared with MVD and Bcl-2 expression assessed with immunohistochemistry on parafín embedded tumor specimens. Results: Sixty-seven tumors were benign and 45 tumors were malignant. The mean age of the studied women was 40,4 years; ±SD, 11,5 years. Color Doppler sonography revealed that in most malignant tumors there was a low resistance to flow (mean PI= 0,56, SD=0,36). Benign tumors also had higher pulsatility indices than malignant tumors (PI=1,21 and SD=0,48; p=0,02, Mann-Whitney U-test). Also, there was a statistically significant difference between MVD in benign and malignant tumors (Mann-Whitney U test, PO.OO 1). No significant difference in the percentage of Bcl-2 stained cells in both malignant and benign tumor samples was found. Conclusion: Microvessel density assessed with CD-34 and color Doppler blood flow assessement are useful in ovarian tumors vascularity studies. Bcl-2 expression is probably not a useful marker of angiogenic tumor character.

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Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features

80%

Wang F., Sun G.-P., Zou Y.-F., Wu Q., Wu H.-Y., Wu J.-F., Zhou J.-D., Chen K., Zhang X.-Z.

Folia Histochemica et Cytobiologica

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2011

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tom 49

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nr 3

5

Current views on apoptosis in theory and medical practice

80%

Szpringer E., Lutnicki K.

Polish Journal of Veterinary Sciences

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2003

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tom 06

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nr 1

Apoptosis is a kind of cell death essential for normal functioning and survival of most multicellular organisms. Apoptosis plays an important role in physiological processes and in pathophysiology of some chronic diseases, including autoimmunity, cancer, lymphoma, AIDS, neurodegeneration and others. The present paper describes the interdisciplinary pathogenesis of programmed cell death, the mechanisms inducing apoptosis and the role of apoptosis in some physiological phenomena and in medical practice.

Ograniczanie wyników

Apoptosis monitoring in human acute leukaemia cells stimulated by Bcl-2 antisense oligonucleotide and BAY K 8644

Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture

A comparison of Bcl-2 expression, microvessel density and color Doppler sonography in the benign and malignant ovarian tumors

Expression of COX-2 and Bcl-2 in primary fallopian tube carcinoma: correlations with clinicopathologic features

Current views on apoptosis in theory and medical practice