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Effect methanolic extract of Achyranthus aspera on biochemical status of Albino mice

100%

Reddy C. V., Kamble A.

International Letters of Natural Sciences

2014

tom 09

The effect of administration of Methanolic extract of Achyranthsu asper on biochemical parameter of mice were investigated. This drug induced significant reduction in the cholesterol level and amount of RNA. But significant increase in the amount of glycogen at 25 mg/kg and no significant reduction in the amount of glycogen at 50 mg/kg. This drug also induced increase in the level of alkaline phospatese and decrease in the level of acid phosphatase, protein and DNA, but these changes are statistically not significant. Protein 25 mg shows 4.22 ±0.112 and 50 mg shows 4.05 ±0.085. Cholesterol 25mg shows 0.5 ±0.04 and 50 mg shows 0.39 ±0.038. Glycogen 25mg shows 0.288 ±0.011 and 50mg shows 0.248 ±0.177. DNA 25mg shows 0.109 ±0.039 and 50 mg shows 0.085 ±0.035, RNA 25mg shows 0.38 ±0.036 and 50 mg shows 0.25 ±0.031

Toxicity study of Achyranthus aspera

100%

Reddy C. V., Kamble A.

International Letters of Natural Sciences

2014

tom 09

The objectives of present work focuses to check the acute and sub acute toxicity studies for the Achyranthes aspera L methanol extract as per OECD guideline in Swiss mice. The dose of 100, 200, 250 gm/kg body weight methanol extract by administering drug intraperitoneally and recorded the growth, body weight, organ weight, general symptoms, morphological and physiological behavior, mortality. These parameters on various organs system in mice were studied. It was considered necessary to assess its potential health hazard in man and to find the safe and effective dose. The observations of changes in body weight, food and water intake as well as cage side observations were reported. There was no abnormality observed in all groups. The whole plant powder methanol extract of Achyranthes Aspera L were found to be nontoxic.

Ograniczanie wyników

2 International Letters of Natural Sciences

2 Kamble A.

2 Reddy C. V.

2 2014

Wyniki wyszukiwania

Effect methanolic extract of Achyranthus aspera on biochemical status of Albino mice

Toxicity study of Achyranthus aspera